pitx2
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  • Official Full Name
  • paired-like homeodomain 2
  • Background
  • This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • PITX2; paired-like homeodomain 2; IHG2, IRID2, paired like homeodomain transcription factor 2 , RGS, RIEG, RIEG1; pituitary homeobox 2; ARP1; Brx1; IGDS; Otlx2; RS; All1 responsive gene 1; ALL1 responsive protein ARP1; ALL1-responsive protein ARP1; ARP 1; Brx 1; Homeobox protein PITX2; IDG 2; IDG2; IGDS 2; IGDS2; IHG 2; IHG2; IRID 2; IRID2; MGC111022; MGC20144; Otlx 2; Paired like homeodomain transcription factor 2; Paired-like homeodomain transcription factor 2; Pituitary homeo box 2; PITX 2; PITX2_HUMAN; PTX 2; PTX2; RGS; RIEG 1; RIEG; Rieg bicoid related homeobox transcription factor 1; RIEG bicoid related homeobox transcription factor; RIEG bicoid-related homeobox transcription factor; RIEG1; Solurshin; OTTHUMP00000163734; OTTHUMP00000163735; OTTHUMP00000163736; OTTHUMP00000163737; OTTHUMP00000163738; OTTHUMP00000219750; OTTHUMP00000219751; all1-responsive gene 1; ALL1-responsive protein
Cat.#:PITX2-134HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PITX2 Protein, GST-HIS-tagged
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Cat.#:PITX2-135HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PITX2 Protein, HIS-tagged
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Cat.#:PITX2-12850MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PITX2 Protein
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Cat.#:PITX2-4477RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PITX2 Protein
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Cat.#:PITX2-6568CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PITX2
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Cat.#:PITX2-8611ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PITX2
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Cat.#:PITX2-3163HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PITX2 293 Cell Lysate
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Cat.#:PITX2-3164HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PITX2 293 Cell Lysate
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Cat.#:PITX2-3165HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PITX2 293 Cell Lysate
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Involved Pathway

PITX2 involved in several pathways and played different roles in them. We selected most pathways PITX2 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PITX2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
SMAD7; IFNG1-2; ACVR2A; BMP2; BMPR2B; LFT2; BMPR1AB; SKP1; GDF6; GDF6A

Protein Function

PITX2 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PITX2 itself. We selected most functions PITX2 had, and list some proteins which have the same functions with PITX2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein BHLHE40; PITX2; NHLH2; IFI27; NFE2L2; TBX3; CREB1; LDB1; ATF2; POU1F1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein POU2F2; RFX1; RELA; FOXJ1; TCF3A; ZNF680; NEUROG3; TBX3; SIX4; EGR2
Function RNA polymerase II transcription coactivator activity
Related Protein PHF17; HYAL2; ANKRD1; TRIM28; RERE; MKL1B; MYOCD; MED12L; POU1F1; PSIP1
Function RNA polymerase II transcription factor binding
Related Protein GATA6; ATF4; MTA2; GFI1B; ZGLP1; TBX6; TOX2; TRPS1; SMAD4; KDM1A
Function identical protein binding
Related Protein ITGB3; APLP1; PVRL2; CLDN16; DAPK1; PRPS2; ZNHIT6; PCNA; C10orf88; TRIM21
Function phosphoprotein binding
Related Protein FKBP4; SNCA; TBL2; RRAGA; SRC; TOX3; PLAT; SAG; YWHAB; MID1
Function protein binding
Related Protein EPS15; HIST1H2AL; EIF4EA; ZFAND6; SERPINA5; PMEPA1; JAG2; VIPR1; COG4; RXRB
Function protein homodimerization activity
Related Protein JAM3; GREM2; NR4A2; INHBB; S100A10; FLNA; TPR; EIF2AK3; TFAP2B; GNB2L1
Function ribonucleoprotein complex binding
Related Protein ITCH; CD2BP2; PES1; WDR12; PRPF31; PES; RNASEL; SRP54; SRP54A; PRPF6
Function transcription factor activity, sequence-specific DNA binding
Related Protein CNOT7; NKX2-5; GLI2; NFIXB; CEBP1; GATAD2AB; FOXO4; MYF6; TBX18; FOXP1B
Function transcription factor binding
Related Protein H2-AB1; IGHMBP2; PDCD11; RBPJ; APBB2; MED25; CREG1; JUNBA; IFI16; PARD6A
Function transcription regulatory region sequence-specific DNA binding
Related Protein NKX3-1; EGR1; KCNA3; NFE2L2B; PSPC1; MKL1; POU2F1; MEF2CA; SIN3A; NFE2L2A
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NR5A2; NR3C1; ONECUT2; ARNT2; FOSB; ISL1; AKNA; ZNF750; TFAP2B; MEF2A
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein BCL11AB; TGIF1; NR2E1; DLX4; GATA1; NFATC2; BHLHE40; NFIL3-5; HHEX; CTCF
Function transcriptional repressor activity, RNA polymerase II transcription factor binding
Related Protein MINA; PITX2; MLIP; AHRRA; RIMKLB; BHLHE40; TBX6; AHRRB; ELP2; EOMES

Interacting Protein

PITX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PITX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PITX2.
Hoxa1; CTNNB1; YBX1; PRKACB; RFC2; CDC37; GPR158; MYC; NCL; HNRNPK; HNRNPU

PITX2 Related Articles

Watson, S; Sarris, M; et al. Limbal Dermoid Epithelium Shares Phenotypic Characteristics Common to Both Hair Epidermal and Limbal Epithelial Stem Cells. CURRENT EYE RESEARCH 38:835-842(2013).
Hatayama, M; Mikoshiba, K; et al. IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 410:520-524(2011).