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PKP1

Official Full Name

plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
Overview

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

B6P; PKP1; MGC138829; Plakophilin 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
His|GST
Myc
DDK
Myc|DDK
N/A
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PKP1-1975H	Recombinant Human PKP1 protein, His & GST-tagged	E.coli	His/GST	Asn500~Asn742 (Accession # Q13835)	Inquiry
Human	PKP1-1365HCL	Recombinant Human PKP1 cell lysate		N/A		Inquiry
Human	PKP1-719H	Recombinant Human PKP1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	PKP1-1882H	Recombinant Human PKP1 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	PKP1-4919H	Recombinant Human PKP1 Protein (Asn500-Asn742), N-GST tagged	E.coli	N-GST	Asn500-Asn742	Inquiry
Mouse	PKP1-12878M	Recombinant Mouse PKP1 Protein	Mammalian Cell	His		Inquiry
Mouse	PKP1-6791M	Recombinant Mouse PKP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Pkp1-4891M	Recombinant Mouse Pkp1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	PKP1-6791M-B	Recombinant Mouse PKP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Pkp1-1943M	Recombinant Mouse Pkp1 Protein, His-tagged	E.coli	N-His	Asn630-Phe728	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PKP1 Related Articles

PKP1 involved in several pathways and played different roles in them. We selected most pathways PKP1 participated on our site, such as Apoptosis, Apoptotic cleavage of cell adhesion proteins, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PKP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Apoptosis	CAPN1A;GAS2;CASP8L1;XIAP;PIK3R5;DSG3;TRP53;HDR;CASP8
Apoptotic cleavage of cell adhesion proteins	DSG1;PKP1;PTBP3;CTNNB2;OCLN;DSG2;DSP;DSG3;CTNNB1
Apoptotic cleavage of cellular proteins	GAS2;DSG1;DSG3;STK24;PTBP3;CASP8L1;DSG2;SATB1;BCAP31
Apoptotic execution phase	DFFA;PTBP3;HIST1H1E;HIST1H1B;HMGB2A;DBNLB;PKP1;SPNA2;CASP6L1
Programmed Cell Death	DSG3;Gzmg;DIABLOB;BMX;DSP;CASP6L1;DBNLA;GZMC;DNM1L

PKP1 has several biochemical functions, for example, intermediate filament binding, lamin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PKP1 itself. We selected most functions PKP1 had, and list some proteins which have the same functions with PKP1. You can find most of the proteins on our site.

Function	Related Protein
intermediate filament binding	SYNM;PKP1;EVPL;EVPLA;MTM1;NME2;PKP2;NES
lamin binding	TMEM201;IFI27;SUN1;SUN2;NARF;PPP4C;SYNE1;TOR1AIP1;PKP1
protein binding	LURAP1;NUP98;PTPN12;BEND5;DDOST;FAM65B;KNDC1;PEF1;TH1L
signal transducer activity	MAGI2;S100A9;CXCR7B;PKP1;CCR6A;OLFR510;OPN4A;ADRB3B;NFKBIB
structural constituent of epidermis	KRT36;PKP1;KRT84;LOR

PKP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PKP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PKP1.

TNS2; USP1; GOSR1; WIPI1; GABARAPL2; GABARAPL1

Muhmer, M; Ditthardt, D; et al. An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b. CELL AND TISSUE RESEARCH 355:143-162(2014).

Hofmann, I; Casella, M; et al. Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. MOLECULAR BIOLOGY OF THE CELL 17:1388-1398(2006).