Pla2
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Official Full Name
phospholipase A2
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Overview
Bee venom phospholipase A2 (PLA) is the main allergen in the bee sting allergy. Bee venom phospholipase A2 (BV-PLA2) is a hydrolytic enzyme which specifically cleaves the sn-2 acyl bond of phospholipids at the lipid/water interface. BV-PLA2 is a 14–16-kDa glycoprotein, consisting of 134 amino acids and displaying a single carbohydrate side chain at the residue Asn13. It is also held to be responsible for some systemic anaphylactic reactions in bee venom sensitized individuals. BV-PLA2 presents 3 peptide and a glycopeptide T cell epitopes, which are recognized by both allergic and non-allergic bee venom sensitized subjects. -
Synonyms
Pla2; phospholipase A2; GB13351; allergen Api m 1; phosphatidylcholine 2-acylhydrolase; EC 3.1.1.4;
- Native Proteins
- Recombinant Proteins
- Assay Kits
- Bee
- E.coli
- Honey Bee Venom
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Bee | Pla2-85A | Active Native Apis mellifera Phospholipase A2 | Honey Bee Venom | N/A |
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| Bee | Pla2-343B | Recombinant Bee Phospholipase A2 | E.coli | N/A |
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| Bee | PLA2-006B | Recombinant Bee PLA2 Protein | E.coli |
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| Kit-0696 | cPLA2 Assay Kit | N/A |
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| Kit-0697 | Cytosolic Phospholipase A2 Assay Kit | N/A |
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| Kit-0699 | sPLA2 Activity Assay Kit | N/A |
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| Kit-1082 | Phospholipase A2 Activity Assay Kit (Fluorometric) | N/A |
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| Kit-0698 | Phospholipases A2 (calcium-dependent cytosolic) Assay Kit | N/A |
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Pla2 involved in several pathways and played different roles in them. We selected most pathways Pla2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Pla2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Pla2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Pla2 itself. We selected most functions Pla2 had, and list some proteins which have the same functions with Pla2. You can find most of the proteins on our site.
| Function | Related Protein |
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Pla2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pla2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Pla2.
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, PLA2 inhibitors have been investigated for their potential in reducing cardiovascular risk, particularly in atherosclerosis.
PLA2 releases arachidonic acid, which serves as a precursor for pro-inflammatory eicosanoids, leading to inflammation.
PLA2 dysfunction is implicated in neurodegenerative diseases like Alzheimer's and Parkinson's, making it a target for research and potential therapies.
Genetic polymorphisms in PLA2 have been studied for their potential links to disease susceptibility, including inflammatory disorders.
Yes, some drugs inhibit PLA2 activity to manage inflammation, as seen in the treatment of rheumatoid arthritis.
Customer Reviews (3)
Write a reviewA manufacturer that can deliver the protein promptly and reliably can save researchers time and allow them to proceed with their experiments without unnecessary delays.
An PLA2 protein manufacturer that also offers related reagents such as antibodies or assay kits can streamline the research process.
This support could range from assisting with experimental design to offering advice on optimal protein handling and storage conditions.
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