pla2g12a
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  • Official Full Name
  • phospholipase A2, group XIIA
  • Background
  • Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids;and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low;specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 (PubMed;11031251)).
  • Synonyms
  • PLA2G12A; phospholipase A2, group XIIA; phospholipase A2, group XII , PLA2G12; group XIIA secretory phospholipase A2; EC 3.1.1.4; Group XIIA secretory phospholipase A2 precursor; GXII sPLA2; Phosphatidylcholine 2 acylhydrolase GXII; Phospholipase A2 group XIIA; PLA2G12; sPLA2-XII; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; GXII; ROSSY
Cat.#:PLA2G12A-1709HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human PLA2G12A Protein (23-185 aa), His-tagged
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Cat.#:PLA2G12A-1881HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G12A Protein, MYC/DDK-tagged
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Cat.#:PLA2G12A-1749HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G12A, GST-tagged
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Cat.#:PLA2G12A-30734THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G12A, His-tagged
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Cat.#:PLA2G12A-72HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phospholipase A2, Group XIIA, His-tagged
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Cat.#:PLA2G12A-12883MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G12A Protein
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Cat.#:Pla2g12a-712MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Phospholipase A2, Group XIIA
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Cat.#:Pla2g12a-8261MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pla2g12a protein, His & T7-tagged
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Cat.#:PLA2G12A-3452RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PLA2G12A Protein, His-tagged
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Cat.#:PLA2G12A-5211ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PLA2G12A
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Cat.#:PLA2G12A-482HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G12A lysate
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Involved Pathway

PLA2G12A involved in several pathways and played different roles in them. We selected most pathways PLA2G12A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
AGPAT3; LYPLA2; PLA2G2E; PLA2G6; GPD1C; PLA2G3; EPT1; DGKE; PCYT1A; LPGAT1
Ether lipid metabolism
PLA2G12B; PLA2G5; PLD2; PLD1; PLA2G4C; PLD3; PLA2G6; PAFAH1B3; TMEM86B; GAL3ST1A
Arachidonic acid metabolism
PLA2G6; CYP2P6; CYP2C54; PLA2G4F; GGTLC1; CYP4F2; PTGS1; GPX3; CBR1L; GGT1
Linoleic acid metabolism
CYP3A25; PLA2G10; PLA2G2A; PLA2G1B; CYP2C70; PLA2G2D; CYP2J6; ALOX15; CYP2C54; CYP2P9
alpha-Linolenic acid metabolism
FADS2; PLA2G2E; PLA2G4AA; PLA2G2F; PLA2G2D; PLA2G2A; ACAA1; PLA2G3; ACAA1A; PLA2G4D
Metabolic pathways
PNLIPRP3; BPNT1; NME2B.1; CBR3; MVK; NDST4; TPH2; CKB; GALNT2; PIP5K1BA
Ras signaling pathway
PIK3R5; MAPK8; PLA2G4A; CALM2; CALM1; FGF2; RASA1; Kitl; CALML5; PRKACG
Vascular smooth muscle contraction
CALM3A; ADCY1A; AVPR1B; MYLK; RHOAA; PLCB3; PLA2G3; MYL9A; CALML5; ROCK2A
Pancreatic secretion
PRKCG; PLA2G1B; RAB8A; PLCB1; CA2; CELA2B; AMY2A4; SLC26A3; GNAS; CLCA2
Fat digestion and absorption
DGAT2; LIPF; CLPS; PLA2G2D; APOA4; MOGAT3; PNLIPRP1; PLA2G10; PLA2G12A; PPAP2A

Protein Function

PLA2G12A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G12A itself. We selected most functions PLA2G12A had, and list some proteins which have the same functions with PLA2G12A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PLCD3A; EGFL8; CALRL2; CALM3A; EFEMP2A; ANXA2A; SLC24A4; SLC24A5; NID2; PLA2G12B
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G12A; PLA2G4F; PLA2G1B; PLA2G4A; PLA2G3; PLA2G2A; PLA2G5; PLA2G4B

Interacting Protein

PLA2G12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G12A.
DVL2; RB1; UMPS; YWHAG; RPS6; RPS15; MEF2C; TMEM37; UCK1; EPB41L3

PLA2G12A Related Articles

Peuravuori, H; Kollanus, S; et al. Expression of group XIIA phospholipase A(2) in human digestive organs. APMIS 122:1171-1177(2014).
Ee, SM; Lo, YL; et al. Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition. MOLECULAR NEUROBIOLOGY 50:60-75(2014).