PLA2G12A Protein, phospholipase A2, group XIIA


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Official Full Name phospholipase A2, group XIIA
Background Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids;and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low;specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 (PubMed;11031251)).
Synonyms PLA2G12A; phospholipase A2, group XIIA; phospholipase A2, group XII , PLA2G12; group XIIA secretory phospholipase A2; EC; Group XIIA secretory phospholipase A2 precursor; GXII sPLA2; Phosphatidylcholine 2 acylhydrolase GXII; Phospholipase A2 group XIIA; PLA2G12; sPLA2-XII; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; GXII; ROSSY
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLA2G12A-1709H Recombinant Human PLA2G12A Protein (23-185 aa), His-tagged Yeast His
    Human PLA2G12A-1749H Recombinant Human PLA2G12A, GST-tagged E.coli GST
    Human PLA2G12A-1881H Recombinant Human PLA2G12A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLA2G12A-30734TH Recombinant Human PLA2G12A, His-tagged E.coli His
    Human PLA2G12A-482HCL Recombinant Human PLA2G12A lysate HEK293 N/A
    Human PLA2G12A-72H Recombinant Human Phospholipase A2, Group XIIA, His-tagged E.coli His
    Mouse PLA2G12A-12883M Recombinant Mouse PLA2G12A Protein Mammalian Cell His
    Mouse Pla2g12a-712M Recombinant Mouse Phospholipase A2, Group XIIA E.coli N/A
    Mouse Pla2g12a-8261M Recombinant Mouse Pla2g12a protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque PLA2G12A-3452R Recombinant Rhesus monkey PLA2G12A Protein, His-tagged Mammalian Cell His
    Zebrafish PLA2G12A-5211Z Recombinant Zebrafish PLA2G12A Mammalian Cell His

    PLA2G12A involved in several pathways and played different roles in them. We selected most pathways PLA2G12A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycerophospholipid metabolism PNPLA6; GPD1C; PLA2G4F; CDIPT; PLA2G2F; LCAT; PLA2G2A; TAE1; LPIN2; DGKAA
    Ether lipid metabolism LPCAT2; CEPT1B; PPAP2D; EPT1; PAFAH2; PPAP2CB; PAFAH1B3; LPCAT4; PLA2G6; UGT8A
    Arachidonic acid metabolism GPX1A; GPX1; CYP2C45; PLA2G10; PTGES2; AKR1C21; CYP2P8; AKR1C3; CYP2J6; CYP4F11
    Linoleic acid metabolism PLA2G1B; CYP2P7; CYP2C38; PLA2G12B; PLA2G12A; CYP3A41B; CYP2J2; PLA2G2E; CYP2C8; CYP2C37
    alpha-Linolenic acid metabolism PLA2G4AA; PLA2G4D; PLA2G6; FADS2; PLA2G2F; ACOX1; ACOX3; PLA2G2A; PLA2G5; PLA2G10
    Metabolic pathways GCDHB; NDUFV3; GAMT; GBGT1; GALNT9; NME1; G6PDX; CHSY3; NDUFS5; SCP2A
    Ras signaling pathway RAB5C; PLD2; FGF19; GAB2; GNG12; PLCG1; RASA4; VEGFA; CALM1; CDC42
    Vascular smooth muscle contraction PRKG1A; CALD1; ARHGEF12; CYP4A14; MAP2K2; CYP4A12A; CALM1B; PLA2G10; MYLK3; RHOA
    Pancreatic secretion ATP1B4; PLA2G10; TPCN2; CD38; Slc4a2; PLA2G2F; RAB8A; CTRB1; ATP2A1; ATP1A4
    Fat digestion and absorption PLA2G2F; PLA2G12B; DGAT1; PNLIP; MTTP; ABCG8; PPAP2A; Cel; PLA2G10; AGPAT1

    PLA2G12A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G12A itself. We selected most functions PLA2G12A had, and list some proteins which have the same functions with PLA2G12A. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding RET; ANXA11A; THBS3A; EFCAB2; MASP2; SYT5A; RHOT1A; CAPNS1B; MAN1A2; PCDH21
    calcium-dependent phospholipase A2 activity PLA2G4B; PLA2G1B; PLA2G2A; PLA2G4A; PLA2G12A; PLA2G5; PLA2G4F; PLA2G3

    PLA2G12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G12A.


    Peuravuori, H; Kollanus, S; et al. Expression of group XIIA phospholipase A(2) in human digestive organs. APMIS 122:1171-1177(2014).
    Ee, SM; Lo, YL; et al. Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition. MOLECULAR NEUROBIOLOGY 50:60-75(2014).

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