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PLEKHA1

  • Official Full Name

    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

  • Overview

    This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
  • Synonyms

    PLEKHA1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; pleckstrin homology domain-containing family A member 1; tandem PH domain containing protein 1; TAPP1; OTTHUMP00000020651; PH domain containing family A member 1; Pleckstrin homology domain containing family A member 1; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member; TAPP 1; OTTHUMP00000020650; OTTHUMP00000206097; tandem PH domain-containing protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLEKHA1-1775H Recombinant Human PLEKHA1, GST-tagged E.coli GST 1-193aa
Human PLEKHA1-1372HCL Recombinant Human PLEKHA1 cell lysate N/A
Human PLEKHA1-2108H Recombinant Human PLEKHA1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLEKHA1-1589H Recombinant Human PLEKHA1 protein, His & T7-tagged E.coli His/T7 Leu92~Glu346 (Accession # Q9HB21)
Human PLEKHA1-2827H Recombinant Human PLEKHA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PLEKHA1-3187H Recombinant Human PLEKHA1 protein, His-tagged E.coli His 119-196 aa
Human PLEKHA1-5066H Recombinant Human PLEKHA1 Protein (Leu92-Glu346), N-His tagged E.coli N-His Leu92-Glu346
Mouse PLEKHA1-12941M Recombinant Mouse PLEKHA1 Protein Mammalian Cell His
Mouse PLEKHA1-6827M-B Recombinant Mouse PLEKHA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Plekha1-1590M Recombinant Mouse Plekha1 protein, His & GST-tagged E.coli His/GST Thr105~Leu351 (Accession # Q8BUL6)
Mouse PLEKHA1-6827M Recombinant Mouse PLEKHA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Plekha1-182M Recombinant Mouse Plekha1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish PLEKHA1-12607Z Recombinant Zebrafish PLEKHA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PLEKHA1 involved in several pathways and played different roles in them. We selected most pathways PLEKHA1 participated on our site, such as B Cell Receptor Signaling Pathway, Class I PI3K signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEKHA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B Cell Receptor Signaling PathwayPTPN6;RAP2A;ARPC1B;SOS1;PPP3CC;TTC6;PIK3R5;BLK;ACTR2
Class I PI3K signaling eventsITK;ADAP1;BLK;ARF1;PLEKHA1

PLEKHA1 has several biochemical functions, for example, PDZ domain binding, phosphatidylinositol-3,4-bisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEKHA1 itself. We selected most functions PLEKHA1 had, and list some proteins which have the same functions with PLEKHA1. You can find most of the proteins on our site.

Function Related Protein
PDZ domain bindingFZD3;DLG4;ATP2B1;LNX1;PLEKHA2;LNX2;FZD1;GIPC1;PARK2
phosphatidylinositol-3,4-bisphosphate bindingZFYVE1;RS1;FAM21C;DAPP1;MYO1G;MAPKAP1;ADAP2;AKT1;COMMD1
protein bindingAPOA1;KCNJ10;TRAIP;TFIP11;AVPR1A;COPG;SLIRP;RIPPLY2;PPP3CC

PLEKHA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEKHA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEKHA1.

MPDZ; PTPN13; SH3BP4; CRKL; queA; pi3p; Lats2

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