pls1
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  • Official Full Name
  • plastin 1
  • Background
  • Fimbrin is an actin cross-linking protein important in the formation of filopodia.Fimbrin belongs to the calponin homology (CH) domain superfamily of actin cross-linking proteins. Like other members of this superfamily, which include α-actinin, β-spectrin, dystrophin, ABP-120 and filamin, it has a conserved 27 kDa actin-binding domain that contains a tandem duplication of a sequence that is homologous to calponin. In addition to cross-linking actin filaments into bundles and networks, CH domains also bind intermediate filaments and some signal transduction proteins to the actin cytoskeleton. Structural comparison of actin filaments and fimbrin CH domain-decorated actin filaments has revealed changes in the actin structure due to fimbrin-mediated cross-linking that may affect the actin filaments" affinity for other actin-binding proteins and may be part of the regulation of the cytoskeleton itself.
  • Synonyms
  • Fimbrin; I Fimbrin; I Plastin; Intestine specific plastin; Plastin 1 (I isoform); Plastin 1; Plastin1; Fimbrin (p67); PLS1
Cat.#:PLS1-6899CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLS1
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Cat.#:PLS1-10253ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PLS1
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Cat.#:PLS1-3097HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLS1 293 Cell Lysate
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Protein Function

PLS1 has several biochemical functions, for example, actin filament binding, calcium ion binding, structural constituent of cytoskeleton. Some of the functions are cooperated with other proteins, some of the functions could acted by PLS1 itself. We selected most functions PLS1 had, and list some proteins which have the same functions with PLS1. You can find most of the proteins on our site.
Function
Related Protein
Function actin filament binding
Related Protein MYO10; MYO3A; ACTN2B; FSCN1; GAS7; MARCKS; ANTXR1; MICALL2; VPS16; FLNC
Function calcium ion binding
Related Protein SLC25A13; PCDH1G1; MATN3A; CAPNS1B; SLIT1B; F9; KCNIP3B; PCDHGB2; CDH17; PCDH1G30
Function structural constituent of cytoskeleton
Related Protein TUBA8L4; ACTL7A; ADD3; PLS1; TUBB; GFAP; TUBE1; ACTL7B; F-KER; TPM1

Interacting Protein

PLS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLS1.
ARF6; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; MYH9; Myh9