PLXNA1
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Official Full Name
plexin A1
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Overview
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. -
Synonyms
PLXNA1; plexin A1; NOV; NOVP; PLXN1; PLEXIN-A1; plexin-A1; plexin 1; semaphorin receptor NOV;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Yeast
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- PLXNA1 Related Research Area
PLXNA1 involved in several pathways and played different roles in them. We selected most pathways PLXNA1 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLXNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | RANBP9;COL4A3;GNAI2;ITSN1;FRS3;HFE2;DUSP10;KALRNB;KCNQ3 |
PLXNA1 has several biochemical functions, for example, receptor activity, semaphorin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLXNA1 itself. We selected most functions PLXNA1 had, and list some proteins which have the same functions with PLXNA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | NLGN2;ITGB4;VMN1R43;LILRB4;GRIA4B;TMEM123;VMN1R46;MCC;NR2C1 |
| semaphorin receptor activity | PLXNA3;PLXND1;PLXNB2;Plxna2;NRP2;NRP2A;NRP1;PLXNC1;PLXNA1B |
PLXNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLXNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLXNA1.
PDIA3
- Q&As
- Reviews
Q&As (7)
Ask a questionPLXNA1 plays a role in the formation of synapses, essential for effective neural communication.
PLXNA1 interacts with various signaling molecules, coordinating complex neural development processes.
Altered PLXNA1 activity is linked to neurodevelopmental disorders due to its role in neuronal guidance and synapse formation.
PLXNA1, a receptor in the plexin family, is crucial for neuronal development and pathway formation.
Targeting PLXNA1 offers potential for treating conditions related to neural development and connectivity.
It guides axon growth and direction, influencing the wiring of the nervous system.
Genetic mutations in PLXNA1 can disrupt neural pathways, affecting brain structure and function.
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