pmch
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  • Official Full Name
  • pro-melanin-concentrating hormone
  • Background
  • The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and;later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona;incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic;distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions;directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other;putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in;many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary;by Nahon et al., 1992 (PubMed 1572663)).
  • Synonyms
  • PMCH; pro-melanin-concentrating hormone; pro-MCH; MCH; melanin-concentrating hormone
Cat.#:PMCH-2149HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PMCH Protein, His-tagged
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Cat.#:PMCH-172HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PMCH, His-tagged
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Cat.#:PMCH-646HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PMCH Protein, His-tagged
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Cat.#:PMCH-4540RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PMCH Protein
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Cat.#:PMCH-4155CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PMCH
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Cat.#:PMCH-8000ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PMCH
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Cat.#:PMCH-488HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PMCH lysate
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Involved Pathway

PMCH involved in several pathways and played different roles in them. We selected most pathways PMCH participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMCH were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
UTS2D; CCR8; PYY; CXCR7B; ADRA1B; CCR5; CCL27; UTS2; PROK2; LPAR5A
G alpha (i) signalling events
GPR18; ADRA2C; CXCL11.8; GPR55A; FPR-RS3; SSTR1; RGS20; CCR9; ADRA2B; SOUL3
G alpha (q) signalling events
MGLL; TRPC6A; APPB; LPAR2A; NMB; TRIO; OPN4B; DGKQ; DGKG; EDNRB
GPCR downstream signaling
PROKR1; OXGR1A.1; CNR1; RASGRP2; PENK; CRHR2; TAS2R16; NMBA; ADRA2A; CALCA
GPCR ligand binding
PROKR2; OPN1MW2; KEL; DRD4; EDN3; CNR1; RAMP3; PENK; FPR-RS3; PNOCB
Gastrin-CREB signalling pathway via PKC and MAPK
PROKR2; GPRC6A; GRP; NMUR1; OXTRL; PROKR1; TAC1; RASGRP2; NMS; RGS21
Peptide ligand-binding receptors
GAL; OXTRL; TAC2; AMCF-II; HEBP1; NMBA; CX3CR1; CCL19A.2; ACKR4; NMU
Signal Transduction
NPB; RDH10; RHOV; OXGR1A.2; RAMP3; AXL; APOA4B.1; PDK2; RHPN1; RDH7

Protein Function

PMCH has several biochemical functions, for example, melanin-concentrating hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PMCH itself. We selected most functions PMCH had, and list some proteins which have the same functions with PMCH. You can find most of the proteins on our site.
Function
Related Protein
Function melanin-concentrating hormone activity
Related Protein PMCHL; PMCH

PMCH Related Articles

Tuziak, SM; Rise, ML; et al. An investigation of appetite-related peptide transcript expression in Atlantic cod (Gadus morhua) brain following a Camelina sativa meal-supplemented feeding trial. GENE 550:253-263(2014).
Walter, LJ; Gasch, CA; et al. Association of pro-melanin concentrating hormone genotype with beef carcass quality and yield. JOURNAL OF ANIMAL SCIENCE 92:325-331(2014).