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PMVK

  • Official Full Name

    phosphomevalonate kinase

  • Overview

    The enzyme phosphomevalonate kinase (PMVK) catalyzes the conversion of 5-phosphomevalonate into 5-diphosphomevalonate in the cholesterol biosynthetic pathway. PMVK is found in the peroxisome of heart, liver, skeletal muscle, kidney and pancreas tissue wit
  • Synonyms

    PMVK; phosphomevalonate kinase; HUMPMKI; PMK; PMKA; hPMK; PMKASE;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PMVK-30069TH Recombinant Human PMVK, His-tagged E.coli His 192 amino acids
Human PMVK-2823H Recombinant Human Phosphomevalonate Kinase, His-tagged E.coli His
Human PMVK-444H Recombinant Human PMVK, His tagged E.coli GST
Human PMVK-1812H Recombinant Human PMVK, GST-tagged E.coli GST 1-192aa
Human PMVK-30070TH Recombinant Human PMVK, His-tagged E.coli His
Human PMVK-3084HCL Recombinant Human PMVK 293 Cell Lysate HEK293 N/A
Human PMVK-6131H Recombinant Human PMVK Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PMVK-1275H Recombinant Human PMVK protein, His-tagged E.coli His Met1-Leu192
Mouse Pmvk-4960M Recombinant Mouse Pmvk Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish PMVK-5431Z Recombinant Zebrafish PMVK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PMVK Related Articles

PMVK involved in several pathways and played different roles in them. We selected most pathways PMVK participated on our site, such as Activation of gene expression by SREBF (SREBP), Cholesterol biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMVK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of gene expression by SREBF (SREBP)PMVK;MTF1;NFYBA;NCOA2;NFYAL;CREBBP;DHCR7;CYP51A1;SREBF2
Cholesterol biosynthesisARV1;SREBF2;DHCR7;PMVK;DHCR24;EBP;CYP51A1;LBR
Metabolic pathwaysPLD1;LPCAT4;B3GNT3;GALNTL5;POLG2;ATP6V0E2;ATP6V0A1;NDUFA2;AMT
MetabolismTREH;CYP2V1;CYP2S1;OXSR1;ACOT2;SLC6A12;CTRC;CETP;NHLRC1
Metabolism of lipids and lipoproteinsCRAT;ACOT6;ACOT10;CYP4F11;CETP;DHCR24;CYP27B1;CYP4F22;SLC25A20
PeroxisomeNOS2B;FAR1;SCP2;ACSL5;DAO.2;PEX7;ACSL4;PRDX1;PIPOX
Regulation of cholesterol biosynthesis by SREBP (SREBF)PMVK;INSIG2;NFYAL;NFYBA;DHCR7;MTF1;NFYBB;SREBF2;INSIG1
Terpenoid backbone biosynthesisFNTB;IDI1;IDI2;FDPS;FNTA;GGPS1;HMGCS1;PDSS1;MVDA

PMVK has several biochemical functions, for example, ATP binding, phosphomevalonate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PMVK itself. We selected most functions PMVK had, and list some proteins which have the same functions with PMVK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRP9B;ABCB10;MYH11A;UBE2G2;PIK3C3;HSPA14;PRKAG3;ATRX;MYO9B
phosphomevalonate kinase activity

PMVK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMVK here. Most of them are supplied by our site. Hope this information will be useful for your research of PMVK.

MPDU1; RGS20; SSB; TBPL1; PITPNA; MLF2; CENPH; q9wmx2-pro_0000037551; VCAM1

Rodriguez, SB; Leyh, TS; et al. An Enzymatic Platform for the Synthesis of Isoprenoid Precursors. PLOS ONE 9:-(2014).
Miziorko, H; VanNice, J; et al. Identification of H. volcanii Phosphomevalonate Decarboxylase and Isopentenyl Phosphate Kinase as Catalysts of the Terminal Enzymatic Reactions in an Archaeal Alternate Mevalonate Pathway. FASEB JOURNAL 28:-(2014).
  • Q&As
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