PNP
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Official Full Name
purine nucleoside phosphorylase
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Overview
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. -
Synonyms
PNP; purine nucleoside phosphorylase; NP, nucleoside phosphorylase; PUNP; FLJ97312; FLJ94043; FLJ97288; Inosine phosphorylase; MGC117396; MGC125915; MGC125916; NP; Np1; Nucleoside phosphorylase; Pnp1; PNPH_HUMAN; PRO1837; Purine nucleoside orthophosphate ribosyltransferase; OTTHUMP00000163992; purine-nucleoside:orthophosphate ribosyltransferase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PNP Related Articles
PNP involved in several pathways and played different roles in them. We selected most pathways PNP participated on our site, such as Purine metabolism, Pyrimidine metabolism, Nicotinate and nicotinamide metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | CANT1B;POLR2E;PGM1;PDE6D;TWISTNB;AK3;GUCY1A3;ENTPD2A.1;NT5M |
| Pyrimidine metabolism | NUDT2;UCKL1;TK1;UPRT;DCK;DPYDB;DUT;PNP6;PROZA |
| Nicotinate and nicotinamide metabolism | NAMPTB;NNMT;AOX2P;NT5C2A;NNT;NT5M;NT5C1AA;NT5C1BA;NT5C2B |
| Metabolic pathways | COX6A2;SMPD4;LIAS;MT-ND1;GAPDHS;G6PC3;ALG14;ASMT;PKM2 |
PNP has several biochemical functions, for example, drug binding, nucleoside binding, phosphate ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNP itself. We selected most functions PNP had, and list some proteins which have the same functions with PNP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | DRD2;RARB;GLRB;CHRNB2;MTOR;UGT1A7;HTR2B;SIGMAR1;FNTB |
| nucleoside binding | ACTN4;PNP;CDA;POLA1;AASS |
| phosphate ion binding | G6PC;SH2B3;CHST14;SLC34A2;PNP;RPH3A;GNG12;ADSSL1;ADSS |
| purine nucleobase binding | PNP;PYGL |
| purine-nucleoside phosphorylase activity | PNP5B;PNP4B;PNP;PNP6;PNP5A;PNP4A |
PNP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNP.
EPB41; MCC; HLA-B; IKBKE; NOS1AP; TP53; APLP1; RBM48; RIF1; CCDC90B; ZHX1; VCAM1; MNDA; IFI16; Ddb1; Tmed10; Batf3
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