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POLA2

Official Full Name

polymerase (DNA directed), alpha 2 (70kD subunit)
Overview

DNA polymerase alpha subunit B is an enzyme that in humans is encoded by the POLA2 gene.
Synonyms

POLA2; polymerase (DNA directed), alpha 2 (70kD subunit); DNA polymerase alpha subunit B; FLJ21662; AI573378; DNA directed DNA polymerase alpha 2; DNA polymerase alpha 70 kDa subunit; DNA polymerase alpha subunit II; DNA polymerase subunit alpha B; DNA polymerase subunit II; FLJ37250; Polymerase (DNA directed), alpha (70kD); OTTHUMP00000231593; polymerase (DNA-directed), alpha (70kD);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLA2-1826H	Recombinant Human POLA2, GST-tagged	E.coli	GST	17-275aa	$319 / 25ug
Human	POLA2-3054HCL	Recombinant Human POLA2 293 Cell Lysate	HEK293	N/A		Inquiry
Rhesus Macaque	POLA2-3502R	Recombinant Rhesus monkey POLA2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	POLA2-3320R	Recombinant Rhesus Macaque POLA2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	POLA2-3320R-B	Recombinant Rhesus Macaque POLA2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	POLA2-9984Z	Recombinant Zebrafish POLA2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLA2 Related Articles

POLA2 involved in several pathways and played different roles in them. We selected most pathways POLA2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	PRPS1;APRT;POLR1C;NT5M;POLR2B;NME4;PDE3B;AK3;PDE7A
Pyrimidine metabolism	CAD;TYMS;UPP1;PNPT1;POLR2A;TK2;TRR1;UPRT;CMPK2
Metabolic pathways	PGAM1;ATP6V0A2B;ACMSD;MVD;HGSNAT;UGDH;POLG2;HPSE;B4GALT4
DNA replication	RFC3;MCM6;RPA1;DNA2;MCM7;GINS4;RFC4;POLE4;PRIM2

POLA2 has several biochemical functions, for example, DNA binding, DNA-directed DNA polymerase activity, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by POLA2 itself. We selected most functions POLA2 had, and list some proteins which have the same functions with POLA2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	CDKN2A;TSN;ZBED5;MSXA;FOXO1B;CRY1;IRX4A;CDX1B;KIN
DNA-directed DNA polymerase activity	CHRAC1;POLD4;POLA1;POLD1;POLG;POLE3;POLL;POLN;POLI
molecular_function	PALM3;ZSWIM7;ZZEF1;SLC45A1;PRNPB;LRRC23;HN1A;TMEM132B;FAM96A
protein heterodimerization activity	HIST1H2B8;HIST1H47;SOS1;HIST1H2AL;HIST4H4;TWIST1;H2AFX;SMC1A;SPTAN1

POLA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLA2.

CHM; CPE; IGFBP3; FGFR3; NR4A1; LRPAP1; ATP5C1; NHP2L1; ITGB3BP; DHX34; SETDB1; EZH2; RNPC4; DCP2; FAM219A; ULK2; STK40; PRPF38A; FRZB; C8orf30A

Lin, JJ; Wang, XD; et al. alpha-1,3-N-acetylgalactose aminotransferase gene 539G > C mutation leads to the A(2)B isoform. GENETICS AND MOLECULAR RESEARCH 13:2987-2993(2014).

Jeng, JE; Tsai, HR; et al. Independent and Additive Interactive Effects Among Tumor Necrosis Factor-alpha Polymorphisms, Substance Use Habits, and Chronic Hepatitis B and Hepatitis C Virus Infection on Risk for Hepatocellular Carcinoma. MEDICINE 88:349-357(2009).