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POLD4

  • Official Full Name

    polymerase (DNA-directed), delta 4

  • Overview

    This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3;to 5 exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the;activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA;helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene.
  • Synonyms

    POLD4; polymerase (DNA-directed), delta 4; DNA polymerase delta subunit 4; DNA polymerase delta smallest subunit p12; p12; POLDS;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLD4-2282H Recombinant Human POLD4, His-tagged E.coli His 130aa
Human POLD4-3051HCL Recombinant Human POLD4 293 Cell Lysate HEK293 N/A
Human POLD4-5944H Recombinant Human POLD4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POLD4-301200H Recombinant Human POLD4 protein, GST-tagged E.coli GST Met1-Leu34
Mouse Pold4-4984M Recombinant Mouse Pold4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque POLD4-3505R Recombinant Rhesus monkey POLD4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque POLD4-3323R Recombinant Rhesus Macaque POLD4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLD4-3323R-B Recombinant Rhesus Macaque POLD4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLD4 Related Articles

POLD4 involved in several pathways and played different roles in them. We selected most pathways POLD4 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismDGUOK;POLR1A;AK3;NME2B.2;ENPP3;GMPR2;POLR1E;RRM1;APRT
Pyrimidine metabolismPOLR1C;RRM2B;ITPA;PNP5A;ENTPD4;UCKL1;POLR2E;POLR2I;POLR3K
Metabolic pathwaysCBR1;POLE4;AOX3;DTYMK;B3GALT2;HMBSB;ALOX5;PAPSS2A;GGPS1
DNA replicationRPA4;RFC2;RFC3;MCM3L;POLA2;MCM4;MCM10;RNASEH2C;MCM2
Base excision repairXRCC1;POLD4;POLE4;TDG.1;UNGA;MPG;POLD2;TDG;PNKP
Nucleotide excision repairGTF2H1;RFC3;COPS7B;GTF2H5;RPA1;CHD1L;ERCC4;COPS4;POLD2
Mismatch repairRFC1;RFC4;MSH2;POLD1;POLD2;MLH1;RPA1;RFC2;MSH3
Homologous recombinationPOLD4;BRCA2;BLM;SHFM1;RAD51L3;RAD51L1;RAD54B;EME1;CDK5R2
HTLV-I infectionPPP3CB;CRTC2;LTA;APC;TBPL1;CCNB2;FZD6;MAPK8;CD3E; CD3D

POLD4 has several biochemical functions, for example, DNA-directed DNA polymerase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLD4 itself. We selected most functions POLD4 had, and list some proteins which have the same functions with POLD4. You can find most of the proteins on our site.

Function Related Protein
DNA-directed DNA polymerase activityPOLG2;POLE3;POLE4;POLA2;POLD3;CHRAC1;DNTT;POLH;POLK
protein bindingVARS;RBM10;PLAC9;PCTP;AGPAT4;RPS18;SOSTDC1B;LONP1;TRIM2

POLD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLD4.

POLD1; POLD2; PCNA; WRNIP1

Huang, QM; Suzuki, M; et al. Downregulation of POLD4 in Calu6 cells results in G1-S blockage through suppression of the Akt-Skp2-p27 pathway. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24:1780-1783(2014).
Song, HF; Chen, HQ; et al. Genome-wide survey and phylogenetic analysis on subunit sequences of eukaryotic DNA polymerase delta. GENETICS AND MOLECULAR RESEARCH 13:9558-9568(2014).
  • Q&As
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