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POLG2

Official Full Name

polymerase (DNA directed), gamma 2, accessory subunit
Overview

DNA polymerasebeta is a distributive polymerase involved in base excision repair which repairs damaged DNA by excising modified bases (oxidized methylated deaminated etc.). It has single-strand DNA binding and deoxyribose phosphodiesterase activities on the N-terminal side and nucleotidyltransferase activity on the C-terminal side. The enzyme is constitutively expressed in growing cells but the level of expression is further increased by treatment with alkylating reagents such as MNNG and MMS.
Synonyms

POLG2; polymerase (DNA directed), gamma 2, accessory subunit; DNA polymerase subunit gamma-2, mitochondrial;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E. coli
E.coli
HEK293
HEK293T
Mammalian cells

Tag

Flag
His
His (Fc)
Avi
His|SUMO
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLG2-3047HCL	Recombinant Human POLG2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	POLG2-1147H	Recombinant Human POLG2 Protein (1-485 aa), His-SUMO-tagged	E.coli	His/SUMO	1-485 aa	Inquiry
Human	POLG2-1729H-B	Recombinant Human POLG2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	POLG2-117H	Recombinant Human POLG2 protein, His-tagged	E. coli	His	1-335 aa	Inquiry
Human	POLG2-293HFL	Recombinant Full Length Human POLG2 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	POLG2-1729H	Recombinant Human POLG2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Polg2-4988M	Recombinant Mouse Polg2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLG2 Related Articles

POLG2 involved in several pathways and played different roles in them. We selected most pathways POLG2 participated on our site, such as Metabolic pathways, Mitochondrial biogenesis, Organelle biogenesis and maintenance, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolic pathways	REV3L;TYR;COQ6;PHOSPHO2;UQCRC2B;MCCC2;PTGESL;CYP7A1A;LIAS
Mitochondrial biogenesis	TFB1M;GABPB1;POLRMT;GABPA;TFB2M;MTERF;C10orf2;PPRC1;POLG2
Organelle biogenesis and maintenance	MRPS26;DYNLL2B;ARF4;IFT20;IFT-20;DYNLL2A;BBS5;MRPS23;TCTN1
Transcriptional activation of mitochondrial biogenesis	GABPB1;PPRC1;POLRMT;MTERF;C10orf2;TFB1M;GABPA;POLG2

POLG2 has several biochemical functions, for example, DNA binding, DNA-directed DNA polymerase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLG2 itself. We selected most functions POLG2 had, and list some proteins which have the same functions with POLG2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	UNCX4.1;SETDB1B;HOXA11B;ARID5B;PAX1A;HDGF;KCNA3;GM14477;HOXA2B
DNA-directed DNA polymerase activity	POLK;POLN;POLD1;POLE4;POLD2;POLD4;POLG2;MYBBP1A;POLH
identical protein binding	APLP1;KCNJ10;SEPHS1;MTSS1;POLG2;ATG16L1;SF1;BAIAP2;CLDN23
protein binding	AIG1;STXBP3;FSHR;STAMBPL1;CLTB;RERG;ITM2A;GRAMD3;STAG1

POLG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of POLG2.

POLG; ssdna_dn

Lee, SK; Zhao, MH; et al. Polymerase subunit gamma 2 affects porcine oocyte maturation and subsequent embryonic development. THERIOGENOLOGY 83:121-130(2015).

Woodbridge, P; Liang, C; et al. POLG mutations in Australian patients with mitochondrial disease. INTERNAL MEDICINE JOURNAL 43:150-156(2013).