polr1b
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  • Official Full Name
  • polymerase (RNA) I polypeptide B, 128kDa
  • Background
  • Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production;of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides,;depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in;yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 (PubMed 8921381)).
  • Synonyms
  • POLR1B; polymerase (RNA) I polypeptide B, 128kDa; DNA-directed RNA polymerase I subunit RPA2; FLJ10816; FLJ21921; RPA2; Rpo1 2; A127; DNA directed RNA polymerase I 135kDa polypeptide; DNA directed RNA polymerase I; DNA directed RNA polymerase I subunit RPA2; MGC131780; OTTHUMP00000161989; OTTHUMP00000203643; OTTHUMP00000203645; POLR 1B; Polymerase (RNA) I polypeptide B 128kDa; Polymerase (RNA) I polypeptide B; RNA polymerase I polypeptide B; RNA polymerase I subunit 2; RPA 135; RPA116; RPA135; DNA-directed RNA polymerase I 135kDa polypeptide; DNA-directed RNA polymerase I 135 kDa polypeptide; Rpo1-2
Cat.#:POLR1B-13087MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLR1B Protein
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Cat.#:POLR1B-4568RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat POLR1B Protein
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Cat.#:POLR1B-3511RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey POLR1B Protein, His-tagged
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Cat.#:POLR1B-10811ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR1B
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Cat.#:POLR1B-3042HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human POLR1B 293 Cell Lysate
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Involved Pathway

POLR1B involved in several pathways and played different roles in them. We selected most pathways POLR1B participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
RRM1; PRPS1; NT5M; PDE3B; TWISTNB; PDE1C; PDE6B; IMPDH1A; NME7; NT5C2A
Pyrimidine metabolism
UCK2A; ENTPD8; UPP2; NT5C2; ITPA; POLR3D; POLA1; CANT1B; CMPK2; POLD1
Metabolic pathways
BDH2; STT3A; NAMPT; ALP3; GPT2L; GCNT1; POLR1A; ALDH3A2A; GALNT12; HMGCR
RNA polymerase
POLR2I; POLR2F; POLR1E; POLR2K; POLR3E; POLR2A; POLR3GL; POLR2G; ZNRD1; POLR2EB

Protein Function

POLR1B has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1B itself. We selected most functions POLR1B had, and list some proteins which have the same functions with POLR1B. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein SNAI3; CCS; TYRP1B; AOC3; SNCA; ADNP; IL1A; MOXD2; S100A5; MT3
Function protein binding
Related Protein RNF7; STK25; SUPV3L1; FAM19A1; NUDT16L1; NECAB3; EFNA1; RRAGC; KCNIP3; AGAP2
Function protein-lysine 6-oxidase activity
Related Protein POLR1B; ABHD1; LOXL2; LOXL3; LOXL4; LOXL2A; LOXL2B; LOX
Function scavenger receptor activity
Related Protein ABHD1; CD163; LOXL3B; SUSD2; CXCL16; TINAGL1; TMPRSS13B; CD5; VTNA; TMPRSS15

Interacting Protein

POLR1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1B here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1B.
POLR1A; HDAC6; NCK1; PIK3R1; USP11; GRB2; NFKBIB; TAF1D; ZNF207; CCND1; AKT2; RPL37; GIT2; LDB1; MED20; ERBB2; ARRB2