POLR2A
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Official Full Name
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
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Overview
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008] -
Synonyms
POLR2A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; RNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HeLa
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | POLR2A-1149H | Active Recombinant Human POLR2A, CT Domain | E.coli | N/A | ||
Human | POLR2A-1148H | Active Human POLR2A | HeLa | N/A | ||
Human | POLR2A-2513H | Active Recombinant Human POLR2A, CT Domain, His-tagged | E.coli | His | ||
Human | POLR2A-8461H | Active Recombinant Human POLR2A, His-tagged | E.coli | His | ||
Human | POLR2A-30767TH | Recombinant Human POLR2A | E.coli | N/A | 580 amino acids | |
Human | POLR2A-29986TH | Recombinant Human POLR2A, His-tagged | E.coli | His | ||
Human | POLR2A-3037HCL | Recombinant Human POLR2A 293 Cell Lysate | HEK293 | N/A | ||
Mouse | POLR2A-13091M | Recombinant Mouse POLR2A Protein | Mammalian Cell | His | ||
Mouse | POLR2A-6920M | Recombinant Mouse POLR2A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | POLR2A-6920M-B | Recombinant Mouse POLR2A Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- POLR2A Related Articles
POLR2A involved in several pathways and played different roles in them. We selected most pathways POLR2A participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Purine metabolism | ADCY1B;PKM2;NME4;NPR2;PAPSS2B;POLD2;POLE;POLE2;PDE9A |
Pyrimidine metabolism | DUT;NME6;NT5C2B;udp;POLE4;POLR3E;UCK2B;ENTPD6;POLR2I |
Metabolic pathways | NDUFAB1A;MGAT5B;PGK2;ALPI;CRYL1;COX6A1;POLR3D;HYAL6;CYP4A14 |
RNA polymerase | POLR2G;ZNRD1;POLR2J2;POLR2B;POLR2H;POLR3GLB;POLR2EB;POLR1C;POLR2J3 |
Huntingtons disease | NDUFS8;COX7A1;POLR2D;SLC25A6;mt-Atp8;NDUFA6;UQCR11;UQCRH;COX7B2 |
Herpes simplex infection | STAT1A;IFNA12;TLR3;TBK1;TAF4B;CLOCKA;H2-AA;IRF9;OAS1 |
Epstein-Barr virus infection | POLR3B;POLR2J3;RBPJL;POLR2E;AKAP8L;YWHAG;PSMC6;RIPK1;PIK3CD |
POLR2A has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2A itself. We selected most functions POLR2A had, and list some proteins which have the same functions with POLR2A. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | HER4.3;TDP2B;HIVEP2;EBF4;BBX;FLI1B;NFE2L1B;NFE2L2B;HMBOX1 |
DNA-directed RNA polymerase activity | POLR2D;POLR3G;POLR3F;POLR2EB;POLR3H;CCDC111;MED20;POLR2A;CRCP |
contributes_to RNA polymerase II activity | POLR2B;POLR2A;POLR2J3;POLR2K;POLR2F;POLR2C;POLR2H;POLR2E;POLR2EB |
RNA-directed RNA polymerase activity | |
metal ion binding | EGR3;CYP2C50;F13A1;MAP3K2;CYGB2;AMY1B;INPP5B;HMOX2;SIRT4 |
poly(A) RNA binding | ILF2;TRMT2A;RBM3;RBM34;NPM3;GPATCH8;CSNK1E;USO1;TBL3 |
protein binding | C19orf10;FSHR;CAPN2;NIPSNAP1;CSNK1D;BOC;CNOT10;ITK;UBASH3B |
contributes_to protein binding | TGFBR3;INHA;INTS10;MEF2A;ACVR2A;CPSF3L;MSH6;MSH2;CRY1A |
ubiquitin protein ligase binding | YWHAE;SPG20;TRIB1;GPI1;LTBR;Fzd4;BLZF1;XRCC5;SMC6 |
POLR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2A.
SUPT5H; PAF1; DDX5; RPRD1B; CDC73
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, identifying mutations in POLR2A can aid in the diagnosis of certain neurodevelopmental disorders.
Research is ongoing to determine if POLR2A expression can serve as a biomarker for cancer diagnosis or prognosis.
In cancer treatment, POLR2A is a potential target for the development of therapies that inhibit its function, thereby suppressing cancer cell growth.
Mutations in POLR2A have been linked to neurodevelopmental disorders, including intellectual disability, autism, and epilepsy.
POLR2A is a key component of RNA polymerase II, which transcribes DNA into mRNA, allowing for gene expression and protein synthesis.
Customer Reviews (3)
Write a reviewmanufacturers often have a wealth of knowledge and expertise in the field of POLR2A protein research.
They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of POLR2A protein in their studies.
the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of POLR2A protein in trials.
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