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POLR2A

  • Official Full Name

    polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

  • Overview

    This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Synonyms

    POLR2A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; RPB1; RPO2; POLR2; POLRA; RPBh1; RPOL2; RpIILS; hsRPB1; hRPB220; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; RNA-directed RNA polymerase II subunit RPB1; DNA-directed RNA polymerase III largest subunit; DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HeLa
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR2A-1149H Active Recombinant Human POLR2A, CT Domain E.coli N/A
Human POLR2A-1148H Active Human POLR2A HeLa N/A
Human POLR2A-2513H Active Recombinant Human POLR2A, CT Domain, His-tagged E.coli His
Human POLR2A-8461H Active Recombinant Human POLR2A, His-tagged E.coli His
Human POLR2A-30767TH Recombinant Human POLR2A E.coli N/A 580 amino acids
Human POLR2A-29986TH Recombinant Human POLR2A, His-tagged E.coli His
Human POLR2A-3037HCL Recombinant Human POLR2A 293 Cell Lysate HEK293 N/A
Mouse POLR2A-13091M Recombinant Mouse POLR2A Protein Mammalian Cell His
Mouse POLR2A-6920M Recombinant Mouse POLR2A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse POLR2A-6920M-B Recombinant Mouse POLR2A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLR2A Related Articles

POLR2A involved in several pathways and played different roles in them. We selected most pathways POLR2A participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismADA;ENTPD2;NUDT16;ZNRD1;GUCY2E;POLR2EB;ENPP3;PDE8B;ADCY2B
Pyrimidine metabolismCDA;PRIM2;DCTPP1;POLR3GL;UPRT;PNP;CTPS2;NT5C;POLR1E
Metabolic pathwaysUGDH;EXTL1;ATP6V0C;DHRS3;ENO2;DLAT;HADHAA;ADK;CKMT1A
RNA polymerasePOLR2K;POLR3E;POLR2L;POLR2I;POLR1C;POLR3GLB;POLR2D;POLR2G;POLR2J
Huntingtons diseaseSP1;GRM5;SLC25A6;POLR2H;DNAH6;POLR2I;mt-Atp8;NDUFC2-KCTD14;NDUFA3
Herpes simplex infectionSRSF5A;OAS1A;PVRL1B;FASLG;IL12B;HLA-DQB1;JAK2A;H2-Q10;NXF2
Epstein-Barr virus infectionPOLR2J2;PSMC4;PIK3CD;HLA-DRA;RBPJL;H2-Q10;MAPK10;TRAF6;PSMC2

POLR2A has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2A itself. We selected most functions POLR2A had, and list some proteins which have the same functions with POLR2A. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNKX6-1;ZNF23;ZNF230;POLG2;TMPO;ZFP865;IRF1B;ZMAT4;HNF1A
DNA-directed RNA polymerase activityRPAP1;CRCP;POLR2EB;POLR2E;MED21;POLR2J;POLR3B;POLR3A;POLR2B
contributes_to RNA polymerase II activityPOLR2H;POLR2E;POLR2J;POLR2K;POLR2A;POLR2L;POLR2J3;POLR2C;POLR2F
RNA-directed RNA polymerase activity
metal ion bindingFCNA;ATP2B3B;KDM7AB;GLRX2;Trf;FDX1B;ZFP746;ACACA;ZNF680
poly(A) RNA bindingBYSL;PSPC1;MAK16;CLNS1A;PUM2;XRCC6;MRPS23;SNRPA;HSPA9
protein bindingLMX1B;STRA13;RPL4;THEM5;SSB;MDFIC;PRKD1;RAD17;HNRNPF
contributes_to protein bindingCPSF3L;MSH2;ACVR2A;MEF2A;TGFBR3;PAK1;MSH6;MLH1;POLR2A
ubiquitin protein ligase bindingHERC2;ACVR1B;NGFR;SMC6;GSK3B;CDC34B;TRP53;SLC25A5;EGR2

POLR2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2A here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2A.

SUPT5H; PAF1; DDX5; RPRD1B; CDC73

Yamada, K; Hayashi, M; et al. Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription. PLOS ONE 8:-(2013).
Komashko, VM; Acevedo, LG; et al. Using ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells. GENOME RESEARCH 18:521-532(2008).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can POLR2A mutations be used for diagnostic purposes? 04/14/2023

Yes, identifying mutations in POLR2A can aid in the diagnosis of certain neurodevelopmental disorders.

Can POLR2A be used as a biomarker for cancer? 12/26/2022

Research is ongoing to determine if POLR2A expression can serve as a biomarker for cancer diagnosis or prognosis.

How is POLR2A targeted in cancer therapy? 05/18/2022

In cancer treatment, POLR2A is a potential target for the development of therapies that inhibit its function, thereby suppressing cancer cell growth.

What diseases are associated with mutations in POLR2A? 08/01/2020

Mutations in POLR2A have been linked to neurodevelopmental disorders, including intellectual disability, autism, and epilepsy.

How does POLR2A function in the context of transcription? 11/07/2017

POLR2A is a key component of RNA polymerase II, which transcribes DNA into mRNA, allowing for gene expression and protein synthesis.

Customer Reviews (3)

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Reviews
08/19/2022

    manufacturers often have a wealth of knowledge and expertise in the field of POLR2A protein research.

    01/30/2022

      They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of POLR2A protein in their studies.

      12/17/2021

        the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of POLR2A protein in trials.

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