polr2i
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  • Official Full Name
  • polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
  • Background
  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.
  • Synonyms
  • POLR2I; polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa; polymerase (RNA) II (DNA directed) polypeptide I (14.5kD); DNA-directed RNA polymerase II subunit RPB9; hRPB14.5; RPB9; DNA directed RNA polymerase II 14.5 kDa polypeptide; DNA directed RNA polymerase II polypeptide I; DNA directed RNA polymerase II subunit I; DNA directed RNA polymerase II subunit RPB9; Polymerase (RNA) II (DNA directed) polypeptide I 14.5kDa; RNA polymerase II subunit B9; RPB14.5; RNA polymerase II 14.5 kDa subunit; DNA-directed RNA polymerase II subunit I; DNA-directed RNA polymerase II 14.5 kDa polypeptide
Cat.#:POLR2I-1847HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2I, GST-tagged
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Cat.#:POLR2I-30766THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2I
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Cat.#:POLR2I-389HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa, His-tagged
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Cat.#:POLR2I-522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2I, His-tagged
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Cat.#:POLR2I-8463HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2I, His-tagged
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Cat.#:POLR2I-13099MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLR2I Protein
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Cat.#:POLR2I-3518RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey POLR2I Protein, His-tagged
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Cat.#:POLR2I-1530ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR2I
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Cat.#:POLR2I-490HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human POLR2I lysate
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Involved Pathway

POLR2I involved in several pathways and played different roles in them. We selected most pathways POLR2I participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2I were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
POLR2K; NT5C2B; ADKB; GC2; PDE4A; NME4; NT5C; ENTPD1; NT5C2; ENPP3
Pyrimidine metabolism
UPRT; UCK2B; PNP; POLD1; UPB1; NT5C1B; udp; POLR2H; POLR2B; UCK1
Metabolic pathways
POLR2G; COX5B; GSS; PCYT2; CYP11B1; MGAT4B; ASAH2; PIGYL; ST6GALNAC5; ATP6V1G1
RNA polymerase
POLR1E; POLR2K; POLR2J; POLR2H; POLR1C; POLR2J3; POLR2J2; TWISTNB; POLR3A; POLR3D
Huntingtons disease
DNAH11; SDHC; ATP5E; NDUFA13; DNAL4; UQCR10; COX4I2; COX6A1; POLR2K; ATP5F1
Epstein-Barr virus infection
HLA-DRB3; HDAC5; HLA-F; MAPK13; POLR1D; POLR2D; PLCG2; PSMD3; PSMD8; Fcer2a

Protein Function

POLR2I has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2I itself. We selected most functions POLR2I had, and list some proteins which have the same functions with POLR2I. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SPI1B; LBX1B; KCNH7; NR2F5; RUNX2B; FOXG1B; NUSAP1; H2AFVB; ZNF3; ZFP382
Function DNA-directed RNA polymerase activity
Related Protein POLRMT; CRCP; POLR2J; MED21; POLR2D; RPAP1; POLR2EB; POLR2B; PRIM2; POLR1C
Function zinc ion binding
Related Protein APIP; NR2F6A; RBBP6; PIAS4B; ZNF84; G2E3; APOBEC4; NR2F2; ASH1L; TET1

Interacting Protein

POLR2I has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2I here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2I.
MED19; MED26; WDR48; TBCD; ssrna_ag; SUPT5H; POLR2F; POLR2G; Gtf2b; MED10; Rprd1b; PCIF1; MED29; CDKN2AIP