polr3k
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  • Official Full Name
  • polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
  • Background
  • This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.
  • Synonyms
  • POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; polymerase (RNA) III (DNA directed) polypeptide K (12.3 kDa); DNA-directed RNA polymerase III subunit RPC10; RPC11; DNA directed RNA polymerase III subunit K; DNA directed RNA polymerase III subunit RPC10; DNA directed RNA polymerases III 12.5 kDa polypeptide; hRPC11; HsC11p; My010; RNA polymerase III subunit C10; RNA polymerase III subunit C11; OTTHUMP00000067145; RNA polymerase III subunit CII; RNA polymerase III 12.5 kDa subunit; RNA polymerase III subunit (hRPC11); DNA-directed RNA polymera; C11; RPC10; RPC12.5; C11-RNP3
Cat.#:POLR3K-1852HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR3K, GST-tagged
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Cat.#:POLR3K-266HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR3K, His-tagged
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Cat.#:POLR3K-674ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR3K
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Cat.#:POLR3K-3020HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human POLR3K 293 Cell Lysate
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Involved Pathway

POLR3K involved in several pathways and played different roles in them. We selected most pathways POLR3K participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR3K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
Adcy4; PDE4D; NT5C3L; ADA; GUCY2F; NT5C1BA; PDE6G; POLR3E; NT5C2A; AK4
Pyrimidine metabolism
NT5C3B; ENTPD5; POLE2; NME2; NUDT2; AK9; POLR2C; DPYDB; NT5C2; PNPT1
Metabolic pathways
GAL3ST1A; ALOX12; BCAT2; ACACA; LDHBA; FUT7; NADK; ACADL; C1GALT1A; AOC3
RNA polymerase
POLR3A; POLR2J2; POLR2C; POLR2D; POLR2GL; POLR3GLB; TWISTNB; POLR1A; POLR2J3; POLR1D
Cytosolic DNA-sensing pathway
LOC100033925; IKBKB; NFKB1; POLR3K; IFNA4; IFNA13; POLR1D; IFNA1; IFNA12; POLR2EB
Epstein-Barr virus infection
TRP53; PIK3R2; POLR1D; POLR2J; CSNK2A2; CSNK2B; HLA-A; CDK1; ENTPD3; PSMC5

Protein Function

POLR3K has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR3K itself. We selected most functions POLR3K had, and list some proteins which have the same functions with POLR3K. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF311; SP4; ZBTB16; RPL6; TRIM21; ENO1; HOXA9A; MYCL1; PPP1R10; DLX6A
Function DNA-directed RNA polymerase activity
Related Protein RPAP1; POLR2GL; POLR3K; POLR3C; POLRMT; POLR2L; POLR2D; CCDC111; POLR1C; POLR2B
Function contributes_to RNA polymerase III activity
Related Protein POLR2E; POLR3GLA; POLR3B; POLR3GLB; POLR3H; POLR2K; POLR3D; POLR1C; POLR3F; POLR2L
Function zinc ion binding
Related Protein TRIM35-28; RNF141; PEG10; LNX1; PDLIM1; TP53I3; WBP2NL; SUV39H1; NR2F5; RXRGB

Interacting Protein

POLR3K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR3K here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR3K.
Ruvbl1; POLR2F; POLR3E