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POLR3K

  • Official Full Name

    polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa

  • Overview

    This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.
  • Synonyms

    POLR3K; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; polymerase (RNA) III (DNA directed) polypeptide K (12.3 kDa); DNA-directed RNA polymerase III subunit RPC10; RPC11; DNA directed RNA polymerase III subunit K; DNA directed RNA polymerase III subunit RPC10; DNA directed RNA polymerases III 12.5 kDa polypeptide; hRPC11; HsC11p; My010; RNA polymerase III subunit C10; RNA polymerase III subunit C11; OTTHUMP00000067145; RNA polymerase III subunit CII; RNA polymerase III 12.5 kDa subunit; RNA polymerase III subunit (hRPC11); DNA-directed RNA polymera; C11; RPC10; RPC12.5; C11-RNP3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR3K-1852H Recombinant Human POLR3K, GST-tagged E.coli GST 1-108aa
Human POLR3K-266H Recombinant Human POLR3K, His-tagged E.coli His 1-108aa
Human POLR3K-3020HCL Recombinant Human POLR3K 293 Cell Lysate HEK293 N/A
Human POLR3K-1482H Recombinant Human POLR3K Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POLR3K-3355H Recombinant Human POLR3K protein, His-SUMO-tagged E.coli His-SUMO 1-108aa
Mouse Polr3k-5009M Recombinant Mouse Polr3k Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish POLR3K-674Z Recombinant Zebrafish POLR3K Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

POLR3K involved in several pathways and played different roles in them. We selected most pathways POLR3K participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR3K were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR3GL;ENPP3;PDE10A;GMPR;PDE6A;ENPP4;PDE6B;POLR3D;ENPP1
Pyrimidine metabolismPOLR1A;TRR1;TWISTNB;POLD1;POLR1B;UPP2;PNP;NME1-NME2;DPYD
Metabolic pathwaysNAT2;HPDB;APIP;ALDH1B1;PAPSS2B;LDHB;QDPR;ATP6V0A4;FDPS
RNA polymerasePOLR1B;POLR2L;POLR2EB;POLR2F;POLR3A;POLR2J2;POLR2J;TWISTNB;POLR2E
Cytosolic DNA-sensing pathwayNFKBIAA;IFNPHI1;POLR3B;IL18;IKBKG;OSTN;IFNA10;IKBKB;IRF3
Epstein-Barr virus infectionTNFAIP3;POLR2A;NFKB1;PRKACG;EP300;FGR;RB1;POLR2G;HSPA1B

POLR3K has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR3K itself. We selected most functions POLR3K had, and list some proteins which have the same functions with POLR3K. You can find most of the proteins on our site.

Function Related Protein
DNA bindingTRIM16;ZBTB3;STAT1A;ZFAND5B;PPARDB;KIAA0020;TBX22;ZNF606;ZNF167
DNA-directed RNA polymerase activityPOLR2I;PRIM2;POLR2E;POLR2J;POLR1C;CRCP;CCDC111;POLR2GL;MED21
contributes_to RNA polymerase III activityPOLR2L;CRCP;POLR3K;POLR2H;POLR3C;POLR3GL;POLR3E;POLR2F;POLR3GLA
zinc ion bindingCPA5;TRIM50;TRIM60;RPS29;NANOS3;MMP26;TRIM8A;RORAB;BTR16

POLR3K has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR3K here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR3K.

Ruvbl1; POLR2F; POLR3E

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