POLRMT
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Official Full Name
polymerase (RNA) mitochondrial (DNA directed)
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Overview
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008] -
Synonyms
POLRMT; polymerase (RNA) mitochondrial (DNA directed); APOLMT; MTRNAP; MTRPOL; h-mtRPOL; DNA-directed RNA polymerase, mitochondrial;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | POLRMT-27748TH | Recombinant Human POLRMT, His-tagged | E.coli | His |
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| Human | POLRMT-1578H | Recombinant Human POLRMT protein | E.coli | N/A |
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| Human | POLRMT-1853H | Recombinant Human POLRMT protein, His-tagged | E.coli | His | 282-405 aa | |
| Human | POLRMT-3019HCL | Recombinant Human POLRMT 293 Cell Lysate | HEK293 | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
POLRMT involved in several pathways and played different roles in them. We selected most pathways POLRMT participated on our site, such as Gene Expression, Mitochondrial Gene Expression, Mitochondrial biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLRMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gene Expression | MED25;TSEN34;GTF3C3;DHX9;SKI;POLR3C;HNRNPL2;ZNF543;MED26 |
| Mitochondrial Gene Expression | PPRC1;TFB2M;POLRMT;ESRRA;PPARGC1B;MTERFD1;TFB1M |
| Mitochondrial biogenesis | POLRMT;POLG2;ESRRA;MTERF;PPARGC1B;GABPB1;TFB1M;PPRC1;TFB2M |
| Mitochondrial transcription initiation | POLRMT;TFB2M |
| Organelle biogenesis and maintenance | IFT172;IQCB1;GABPB1;ARF4;TMEM216;BBS5;CEP89;EXOC6;GADD45GIP1 |
| RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | BRF2;SNAPC5;SNAPC1B;CHD4A;SNAPC2;GTF3A;GTF3C2;POU2F1;CRCP |
| Transcription from mitochondrial promoters | MTERF;TFB2M;POLRMT |
| Transcriptional activation of mitochondrial biogenesis | PPRC1;POLRMT;TFB1M;GABPB1;POLG2;MTERF;GABPA;C10orf2 |
POLRMT has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLRMT itself. We selected most functions POLRMT had, and list some proteins which have the same functions with POLRMT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ENG1B;FOSL1A;H3F3B.1;ZFY2;LHX2B;POU6F2;NHEJ1;APLP2;ZNF729 |
| DNA-directed RNA polymerase activity | POLR3G;RPAP1;POLR2M;POLRMT;POLR3B;POLR2E;POLR2I;POLR3C;POLR2D |
| poly(A) RNA binding | DQX1;RPL18A;NOL12;EWSR1;SAFB2;RPUSD4;NOC3L;EIF3I;CCDC137 |
| protein binding | NR2F1;HOXB6;DAPP1;KCND3;ARNTL1B;AHR;ATP6V1D;HTRA2;UPF3B |
POLRMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLRMT here. Most of them are supplied by our site. Hope this information will be useful for your research of POLRMT.
TFB1M; NFKBIA; NFKB2; KBTBD7; ssrna_ug
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, POLRMT mutations can result in energy metabolism deficiencies as they affect the transcription of mitochondrial genes essential for oxidative phosphorylation.
There is emerging evidence suggesting a potential link between alterations in POLRMT expression and certain neurodegenerative diseases, highlighting its role in neuronal health.
POLRMT expression levels and mutations can serve as diagnostic markers for mitochondrial disorders, aiding in the identification and characterization of these conditions.
POLRMT is most active in tissues with high energy demands, such as muscle and brain tissues, where mitochondrial function is crucial for cellular activities.
Currently, there are no specific drugs targeting POLRMT, but research is ongoing to identify compounds that can modulate its activity for therapeutic benefits.
Customer Reviews (3)
Write a reviewTheir expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.
Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.
The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.
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