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POR

  • Official Full Name

    P450 (cytochrome) oxidoreductase

  • Overview

    This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
  • Synonyms

    POR; P450 (cytochrome) oxidoreductase; CPR; CYPOR; P450R; NADPH--cytochrome P450 reductase; NADPH-dependent cytochrome P450 reductase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • 6×His
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • Tag
  • DDK
  • N/A
  • N
  • mSUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POR-7966H Recombinant Human POR protein, His & T7-tagged E.coli His/T7 Gly77~Phe518 (Accession # P16435)
Human POR-217H Recombinant Human POR, GST-tagged Sf9 Insect Cell GST
Human POR-1336H Recombinant Human POR Protein, GST-tagged E.coli GST
Human POR-26693TH Recombinant Human POR Wheat Germ N/A 680 amino acids
Human POR-3006HCL Recombinant Human POR 293 Cell Lysate HEK293 N/A
Human POR-387HF Recombinant Full Length Human POR Protein In Vitro Cell Free System 680 amino acids
Human POR-38H Active Recombinant human POR protein (43-677aa), C-6×His-tagged Insect Cell C-6×His 43-677
Human POR-01H Active Recombinant human POR Protein, His-tagged Insect Cell His-Tag 1-680aa
Human POR-761H Recombinant Human POR Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POR-846HFL Recombinant Full Length Human POR Protein, C-Flag-tagged Mammalian cells Flag
Human POR-2668H Recombinant Human POR protein(61-250 aa), N-mSUMO & C-His-tagged E. coli N-mSUMO & C-His 61-250 aa
Human POR-2667H Recombinant Human POR protein(61-250 aa), C-His-tagged E. coli C-His 61-250 aa
Human POR-1735H Recombinant Human POR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human POR-4956H Recombinant Human POR Protein (Ile80-Pro521), N-His tagged E.coli N-His Ile80-Pro521
Human POR-1735H-B Recombinant Human POR Protein Pre-coupled Magnetic Beads HEK293
Mouse POR-13130M Recombinant Mouse POR Protein Mammalian Cell His
Mouse Por-3357M Recombinant Mouse Por protein, His-tagged E.coli His 276-525aa
Mouse Por-5016M Recombinant Mouse Por Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse POR-6946M Recombinant Mouse POR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse POR-6946M-B Recombinant Mouse POR Protein Pre-coupled Magnetic Beads HEK293
Mouse Por-3358M Recombinant Mouse Por protein, His&Myc-tagged E.coli His&Myc 276-525aa
Rat POR-4581R Recombinant Rat POR Protein Mammalian Cell His
Rat Por-7967R Recombinant Rat Por protein, His & T7-tagged E.coli His/T7 Gly210~Glu578 (Accession # P00388)
Rat POR-4241R-B Recombinant Rat POR Protein Pre-coupled Magnetic Beads HEK293
Rat POR-4241R Recombinant Rat POR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POR-3530R Recombinant Rhesus monkey POR Protein, His-tagged Mammalian Cell His
Rhesus Macaque POR-3348R Recombinant Rhesus Macaque POR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POR-3348R-B Recombinant Rhesus Macaque POR Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POR-3457Z Recombinant Zebrafish POR Mammalian Cell His
Chicken POR-4156C Recombinant Chicken POR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POR Related Articles
  • POR Related Research Area

POR involved in several pathways and played different roles in them. We selected most pathways POR participated on our site, such as bile acid biosynthesis, neutral pathway, cytochrome P450, melatonin degradation I, which may be useful for your reference. Also, other proteins which involved in the same pathway with POR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
bile acid biosynthesis, neutral pathwayACAA2;POR
cytochrome P450CYB5R3;CYP2A7;CYB5B;CYP2W1;CYP4V2;POR;CYB5A;CYP4Z1;CYP20A1
melatonin degradation I
superpathway of melatonin degradation
superpathway of tryptophan utilization
vitamin D3 biosynthesis

POR has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POR itself. We selected most functions POR had, and list some proteins which have the same functions with POR. You can find most of the proteins on our site.

Function Related Protein
FMN bindingNOS2B;TYW1B;MTRR;POR;HAO1;NOS2;TYW1;CREG1;NDOR1
NADP bindingMTHFR;DPYD;MIOX;ME1;MTRR;NOS3;GAPDH;GAPDHS;FMO2
NADPH-hemoprotein reductase activityNOS2A;NOS3;POR;MTRR;NDOR1;NOS1;CYP2J6;NOS2;NOS2B
cytochrome-b5 reductase activity, acting on NAD(P)HCYB5RL;CYB5R3;NQO1;CYB5R1;CYB5R4;CYB5R2;POR
electron carrier activityADH5;IVD;GLRX;NCF1;NDUFV2;PTGES2;CYCSB;PTGESL;FDX1B
enzyme bindingHAND1;PGR;TSPAN33;HIST1H2AD;PARP4;NR5A1;CABYR;CLSTN2;Slc4a2
flavin adenine dinucleotide bindingGFER;MAOA;ACOX2;AIFM2;ACAD11;FMO5;XDH;NOS1;IVD
hydrolase activitySPACA5;BMP1B;GM5077;ATP1A1A.4;FAAH2B;PGAM1;PLA2G2F;CTDNEP1A;TP53RK
iron ion bindingP4HA1B;CYP4V8;CYP4F3;EGLN1;CYGB;Agmo;CYP4V7;OGFOD3;CYP3C1L2
iron-cytochrome-c reductase activity
nitric oxide dioxygenase activityPOR;CYGB
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenMICAL1;MICAL2;COQ6;CYP11B1;CYP2E1;MTRR;CYP4F18;CYP11B2;CYP4F11
protein bindingHBQ1;STAT3;FIG4;TRIM72;PSMB4;CD48;ADAT2;NEBL;PTPN2

POR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POR here. Most of them are supplied by our site. Hope this information will be useful for your research of POR.

PGRMC1; CYP2C2; Hmox1; XRCC6; STAT1; RABEPK

Gonzales, I; Miranda, JJ; et al. Seizures, cysticercosis and rural-to-urban migration: the PERU MIGRANT study. TROPICAL MEDICINE & INTERNATIONAL HEALTH 20:546-552(2015).
Sancak, A; Favrot, C; et al. Antibody titres against canine papillomavirus 1 peak around clinical regression in naturally occurring oral papillomatosis. VETERINARY DERMATOLOGY 26:57-+(2015).
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