POT1
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Official Full Name
protection of telomeres 1
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Overview
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] -
Synonyms
POT1; protection of telomeres 1; HPOT1; protection of telomeres protein 1; protection of telomeres 1 homolog; POT1-like telomere end-binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | POT1-27935TH | Recombinant Human POT1 | Wheat Germ | N/A | 95 amino acids | |
Human | POT1-3005HCL | Recombinant Human POT1 293 Cell Lysate | HEK293 | N/A | ||
Human | POT1-2788H | Recombinant Human POT1 Protein, Flag-tagged | HEK293 | Flag | ||
Human | POT1-6798HF | Recombinant Full Length Human POT1 Protein, GST-tagged | In Vitro Cell Free System | GST | 634 amino acids | |
Human | POT1-2787H | Recombinant Human POT1 Protein, GST-tagged | Wheat Germ | GST | 1-634 a.a. | |
Human | POT1-141HFL | Active Recombinant Full Length Human POT1 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | POT1-5057H | Recombinant Human POT1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | POT1-2608H | Recombinant Human POT1 Protein, His-tagged | E.coli | N-His | Met1-Ala177 | |
Human | POT1-1737H | Recombinant Human POT1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | POT1-1737H-B | Recombinant Human POT1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | POT1-8074Z | Recombinant Zebrafish POT1 | Mammalian Cell | His | ||
Chicken | POT1-7115C | Recombinant Chicken POT1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- POT1 Related Articles
POT1 involved in several pathways and played different roles in them. We selected most pathways POT1 participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with POT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cell Cycle | RBL1;CEP164;RAD21A;MCM10;LIN9;SGOL1;PDS5A;GINS3;CDC27 |
Cellular Senescence | CDKN2C;HIST1H1C;PHC3;KAT5;MAPKAPK2B;HMGA1-RS1;CBX6A;TXN;MOV10 |
Cellular responses to stress | ERF;HIST1H1B;RING1;CBX8A;PRDX3;CDKN2B;KDM6B;EEF1A1;RRAGB |
Chromosome Maintenance | DKC1;CENPW;CENPA;HJURP;MIS18A;WRAP53;TINF2;POLD3;CENPQ |
DNA Damage/Telomere Stress Induced Senescence | POT1A;HIST1H1D;HTATIP;EP400;UBN1;RAD50;H1F0;HIST1H1B;TERF2IP |
Meiosis | TEX12;SYCP2;SYCE1;POT1;MND1;TERF2IP;SPO11;MSH4;STAG1 |
Meiotic synapsis | FKBP6;STAG1;DIDO1;SUN2;POT1;TEX12;TINF2;SYNE2;SYCP1 |
Packaging Of Telomere Ends | ACD;TERF2;POT1A;TINF2;POT1;TERF1 |
POT1 has several biochemical functions, for example, DEAD/H-box RNA helicase binding, G-rich strand telomeric DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POT1 itself. We selected most functions POT1 had, and list some proteins which have the same functions with POT1. You can find most of the proteins on our site.
Function | Related Protein |
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DEAD/H-box RNA helicase binding | POT1;ETV3;POT1A;AKAP8L |
G-rich strand telomeric DNA binding | CTC1;POT1A;CDAN1;POT1 |
protein binding | ACE2;PRAME;MS4A12;SLC3A2;RUFY4;RAB5C;GSTO1;DHX9;PKD2 |
single-stranded telomeric DNA binding | HNRNPA2B1;POT1;POT1A;OBFC1 |
telomerase inhibitor activity | MCRS1;POT1A;PINX1;POT1 |
POT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POT1.
ACD; TERF2; CFL2; TINF2; TERF2IP
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