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POT1

  • Official Full Name

    protection of telomeres 1

  • Overview

    This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Synonyms

    POT1; protection of telomeres 1; HPOT1; protection of telomeres protein 1; protection of telomeres 1 homolog; POT1-like telomere end-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POT1-27935TH Recombinant Human POT1 Wheat Germ N/A 95 amino acids
Human POT1-3005HCL Recombinant Human POT1 293 Cell Lysate HEK293 N/A
Human POT1-2788H Recombinant Human POT1 Protein, Flag-tagged HEK293 Flag
Human POT1-6798HF Recombinant Full Length Human POT1 Protein, GST-tagged In Vitro Cell Free System GST 634 amino acids
Human POT1-2787H Recombinant Human POT1 Protein, GST-tagged Wheat Germ GST 1-634 a.a.
Human POT1-141HFL Active Recombinant Full Length Human POT1 Protein, C-Flag-tagged Mammalian cells Flag
Human POT1-5057H Recombinant Human POT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POT1-2608H Recombinant Human POT1 Protein, His-tagged E.coli N-His Met1-Ala177
Human POT1-1737H Recombinant Human POT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human POT1-1737H-B Recombinant Human POT1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POT1-8074Z Recombinant Zebrafish POT1 Mammalian Cell His
Chicken POT1-7115C Recombinant Chicken POT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POT1 Related Articles

POT1 involved in several pathways and played different roles in them. We selected most pathways POT1 participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with POT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CycleRBL1;CEP164;RAD21A;MCM10;LIN9;SGOL1;PDS5A;GINS3;CDC27
Cellular SenescenceCDKN2C;HIST1H1C;PHC3;KAT5;MAPKAPK2B;HMGA1-RS1;CBX6A;TXN;MOV10
Cellular responses to stressERF;HIST1H1B;RING1;CBX8A;PRDX3;CDKN2B;KDM6B;EEF1A1;RRAGB
Chromosome MaintenanceDKC1;CENPW;CENPA;HJURP;MIS18A;WRAP53;TINF2;POLD3;CENPQ
DNA Damage/Telomere Stress Induced SenescencePOT1A;HIST1H1D;HTATIP;EP400;UBN1;RAD50;H1F0;HIST1H1B;TERF2IP
MeiosisTEX12;SYCP2;SYCE1;POT1;MND1;TERF2IP;SPO11;MSH4;STAG1
Meiotic synapsisFKBP6;STAG1;DIDO1;SUN2;POT1;TEX12;TINF2;SYNE2;SYCP1
Packaging Of Telomere EndsACD;TERF2;POT1A;TINF2;POT1;TERF1

POT1 has several biochemical functions, for example, DEAD/H-box RNA helicase binding, G-rich strand telomeric DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POT1 itself. We selected most functions POT1 had, and list some proteins which have the same functions with POT1. You can find most of the proteins on our site.

Function Related Protein
DEAD/H-box RNA helicase bindingPOT1;ETV3;POT1A;AKAP8L
G-rich strand telomeric DNA bindingCTC1;POT1A;CDAN1;POT1
protein bindingACE2;PRAME;MS4A12;SLC3A2;RUFY4;RAB5C;GSTO1;DHX9;PKD2
single-stranded telomeric DNA bindingHNRNPA2B1;POT1;POT1A;OBFC1
telomerase inhibitor activityMCRS1;POT1A;PINX1;POT1

POT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POT1.

ACD; TERF2; CFL2; TINF2; TERF2IP

Singh, U; Maturi, V; et al. Evidence for multiple forms and modifications of human POT1. DNA REPAIR 12:876-877(2013).
Qing, YF; Zhou, JG; et al. Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL 32:2503-2510(2012).
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