pot1
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  • Official Full Name
  • protection of telomeres 1
  • Background
  • This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
  • Synonyms
  • POT1; protection of telomeres 1; HPOT1; protection of telomeres protein 1; protection of telomeres 1 homolog; POT1-like telomere end-binding protein;
Cat.#:POT1-2787HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human POT1 Protein, GST-tagged
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Cat.#:POT1-2788HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human POT1 Protein, Flag-tagged
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Cat.#:POT1-27935THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human POT1
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Cat.#:POT1-7115CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken POT1
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Cat.#:POT1-8074ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POT1
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Cat.#:POT1-3005HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human POT1 293 Cell Lysate
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Involved Pathway

POT1 involved in several pathways and played different roles in them. We selected most pathways POT1 participated on our site, such as Cell Cycle, Cellular Senescence, Cellular responses to stress, which may be useful for your reference. Also, other proteins which involved in the same pathway with POT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
PSMC3IP; PLK1; CSNK1E; DNA2; CP110; NDE1; PIANP; CDC25C; MDM2; ORC1L
Cellular Senescence
ERF; BMI1A; HIST4H4; H3F3B.1; PHC1; UBN1; CBX6A; RNF2; SCMH1; RBBP4
Cellular responses to stress
NUPL2; ATG9B; EED; PHC1; NUP50; RRAGA; ASF1A; AGO1; CBX6A; BMI1B
Chromosome Maintenance
CENPA; CENPN; NPM1; ACD; APITD1; CENPI; MIS18BP1; PANE1; POT1; SMARCA5
DNA Damage/Telomere Stress Induced Senescence
HMGA1; H1F0; TINF2; HIST1H1B; TERF1; POT1; RAD50; EP400; HMGA1-RS1; HIST1H1C
Meiosis
SPO11; DIDO1; MND1; TEX15; MSH4; TERF1; FKBP6; STAG1; SYCE1; ACD
Meiotic synapsis
STAG2; DIDO1; FKBP6; TERF1; POT1A; SYCE1; SYNE2; ACD; TERF2IP; POT1
Packaging Of Telomere Ends
TERF2; POT1A; TINF2; POT1; ACD; TERF1

Protein Function

POT1 has several biochemical functions, for example, DEAD/H-box RNA helicase binding, G-rich strand telomeric DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POT1 itself. We selected most functions POT1 had, and list some proteins which have the same functions with POT1. You can find most of the proteins on our site.
Function
Related Protein
Function DEAD/H-box RNA helicase binding
Related Protein POT1; POT1A; ETV3; AKAP8L
Function G-rich strand telomeric DNA binding
Related Protein POT1; POT1A; CDAN1; CTC1
Function protein binding
Related Protein PRCC; MR1; RNASEL; PFDN2; ERC2; ASCL1; SLC6A20; MTF1; UBE2E2; ASCC1
Function single-stranded telomeric DNA binding
Related Protein HNRNPA2B1; POT1A; POT1; OBFC1
Function telomerase inhibitor activity
Related Protein POT1; POT1A; PINX1; MCRS1

Interacting Protein

POT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POT1.
ACD; TERF2; CFL2; TINF2; TERF2IP

POT1 Related Articles

Singh, U; Maturi, V; et al. Evidence for multiple forms and modifications of human POT1. DNA REPAIR 12:876-877(2013).
Qing, YF; Zhou, JG; et al. Altered expression of TPP1 in fibroblast-like synovial cells might be involved in the pathogenesis of rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL 32:2503-2510(2012).