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WISP3

  • Official Full Name

    WNT1 inducible signaling pathway protein 3

  • Overview

    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    WISP3; WNT1 inducible signaling pathway protein 3; WNT1-inducible-signaling pathway protein 3; CCN6; WISP-3; CCN family member 6; PPD; LIBC; PPAC; MGC125987; MGC125988; MGC125989;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Fc
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human WISP3-184H Active Recombinant Human WNT1 Inducible Signaling Pathway Protein 3 E.coli N/A
Human WISP3-530H Active Recombinant Human WISP3 Protein E.coli N/A
Human WISP3-31250TH Recombinant Human WISP3, Fc-tagged E.coli Fc
Human WISP3-306HCL Recombinant Human WISP3 293 Cell Lysate HEK293 N/A
Mouse WISP3-18557M Recombinant Mouse WISP3 Protein Mammalian Cell His
Mouse WISP3-10185M Recombinant Mouse WISP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse WISP3-10185M-B Recombinant Mouse WISP3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish WISP3-7601Z Recombinant Zebrafish WISP3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • WISP3 Related Research Area

WISP3 involved in several pathways and played different roles in them. We selected most pathways WISP3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WISP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

WISP3 has several biochemical functions, for example, growth factor activity, heparin binding, insulin-like growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP3 itself. We selected most functions WISP3 had, and list some proteins which have the same functions with WISP3. You can find most of the proteins on our site.

Function Related Protein
growth factor activityJAG1;AMH;GDF9;NTF4;EPGN;BMP7B;FGF20A;PDGFAB;Kitl
heparin bindingOVALX;PGF;WISP2;C6orf25;LRPAP1;COL25A1;LTBP2;FGFR2;ABP1
insulin-like growth factor bindingWISP1;CTGFB;IGF2R;KAZALD1;IGFBP1B;IGF1RB;IGFBP3;IGFBP2B;IGF1R
integrin bindingCXADR;MFGE8;NOV;ACTN1;THY1;NF2;ACTN2;LYN;ITGB1

WISP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP3.

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