ppargc1a
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  • Official Full Name
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
  • Background
  • The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
  • Synonyms
  • PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , PPARGC1; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; LEM6; Ligand effect modulator 6; Peroxisome proliferative activated receptor gamma coactivator 1 alpha; Peroxisome proliferative activated receptor gamma coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1-alpha; PGC1(alpha); PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator 1-alpha; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC1; PRGC1_HUMAN; OTTHUMP00000123372; ligand effect modulator-6; PGC-1v; PGC-1(alpha)
Cat.#:PPARGC1A-729HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARGC1A Protein, His-tagged
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Cat.#:PPARGC1A-8291HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PPARGC1A protein, GST-tagged
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Cat.#:PPARGC1A-13163MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARGC1A Protein
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Cat.#:Ppargc1a-8492MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppargc1a protein, His-tagged
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Cat.#:PPARGC1A-4594RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ppargc1a protein, His-tagged
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Involved Pathway

PPARGC1A involved in several pathways and played different roles in them. We selected most pathways PPARGC1A participated on our site, such as AMPK signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMPK signaling pathway
FBP2; G6PC; ELAVL1; SREBF1; PIK3CG; TSC1; ADIPOQ; STK11; PPP2R1A; RAB14
Insulin signaling pathway
PYGMA; PPARGC1A; CALML5; PHKG1B; PIK3R3; INSRA; SOCS1; GYS1; PRKACG; G6PC2
Adipocytokine signaling pathway
TRAF2; MAPK8A; STK11; RXRBA; MAPK9; CAMKK2; ACSL1B; RXRGB; LEPA; TNF
Glucagon signaling pathway
CREB3L3; G6PC3; PRMT1; GNAS; CREB3L1; PPP3CB; PRKACB; FBP1; PPP3CA; SLC2A2
Insulin resistance
FOXO1A; PRKAG3; INSRB; IL6; PIK3CG; PTPN11B; PPP1CAB; PRKAB2; PPP1R3D; NFKBIA
Huntingtons disease
SIN3A; Casp3; SOD1; POLR2L; NDUFS1; GNAQ; TFAM; COX7B2; UCP1; NDUFS4

Protein Function

PPARGC1A has several biochemical functions, for example, DNA binding, RNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1A itself. We selected most functions PPARGC1A had, and list some proteins which have the same functions with PPARGC1A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RARAA; SOX6; ZNF565; SMTNL; ZFP629; INSM2; ZNF643; H1M; ZFP865; MAP3K7
Function RNA binding
Related Protein HNRNPA1; ELAVL4; RPL4; CPEB3; NHP2L1A; HNRNPA0; YTHDC1; WT1; RPL31; SRSF3
Function RNA polymerase II transcription cofactor activity
Related Protein RBM14; NKX2-5; MED13; MED7; MED9; MED15; PPRC1; NKX2; MED8; PPARGC1B
Function alpha-tubulin binding
Related Protein ARL4C; C9orf24; HDAC6; ARL8A; SNCA; FNTA; NCALD; B4GALT1; SERPINB1A; FAM110C
Function chromatin DNA binding
Related Protein SRF; PRDM14; SMAD3; MYOG; BCL6; PER1; ZIC2; RUVBL2; H2AFZ; H2AFY
Function chromatin binding
Related Protein NUP62; MPO; GLI2; RBPJL; RERE; PDX1; PYGO2; NONO; LMO2; SMARCA2
Function estrogen receptor binding
Related Protein TRIP4; MMS19; PPARGC1B; DDX5; WIPI1; HSD17B10; DDX17; PPID; PADI2; PCNA
Function ligand-dependent nuclear receptor binding
Related Protein NCOA2; ISL1; TRIP4; NR1H4; SLC30A9; UBA3; NCOA1; BAZ2A; SMARCD3; SRA1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein MED17; MED14; MED4; USP22; PUS1; SS18; MED1; FGF2; SLC30A9; NCOA1
Function nucleic acid binding
Related Protein PRDM1A; ZFP775; ZFP74; ZFP473; ZBTB2B; MTHFSD; KLF18; CIRBPA; ZKSCAN6; RBM14B
Function nucleotide binding
Related Protein RAC3A; TRNAU1APA; SRPK1B; CPSF6; IIGP1; GM7168; RBM17; ARF6B; ACTR1; SCAF8
Function peroxisome proliferator activated receptor binding
Related Protein ASXL1; CREBBP; PPARGC1A; HMGA1; ASXL2; HMGA1-RS1; EP300; NR0B2; PRMT2; MED1
Function promoter-specific chromatin binding
Related Protein PPARGC1A
Function protein binding
Related Protein CD4; GRIN2D; Tnfrsf23; FAM127B; LCE1B; ATG9A; MAL; CXCL14; CNOT2; AIPL1
Function sequence-specific DNA binding
Related Protein SIX1B; HOXD13A; ZFP423; SMAD3; HOXD10A; HOXA9A; HOXA4; HOXC8; EMX3; LMX1BA
Function transcription coactivator activity
Related Protein PRMT2; ABRA; CRSP7; TADA1; NR2F1; AIP; MED14; STIL; ZEB1; PER2
Function transcription factor binding
Related Protein PDX1; PBX2; TFAP2A; ESRRB; WWP2; CEBPB; TRERF1; MLXIPL; GATA6; Ar
Function ubiquitin protein ligase binding
Related Protein LC3; TMEM173; GPR37; SCN5A; Fzd4; PINK1; CD40; DLG3; TMEM189; NAE1

Interacting Protein

PPARGC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1A.
Sirt1; Irf4; Lrpprc; LRPPRC; IQGAP1; EP300; SIRT1; NR1I2