ppargc1a
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  • Official Full Name
  • peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
  • Background
  • The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
  • Synonyms
  • PPARGC1A; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 , peroxisome proliferative activated receptor, gamma, coactivator 1, alpha , PPARGC1; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC1; PGC1A; LEM6; Ligand effect modulator 6; Peroxisome proliferative activated receptor gamma coactivator 1 alpha; Peroxisome proliferative activated receptor gamma coactivator 1; Peroxisome proliferator activated receptor gamma coactivator 1 alpha; PGC 1 (alpha); PGC 1 alpha; PGC 1v; PGC-1-alpha; PGC1(alpha); PGC1v; PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6; PPAR gamma coactivator 1 alpha; PPAR gamma coactivator 1; PPAR gamma coactivator 1-alpha; PPAR gamma coactivator variant form; PPAR-gamma coactivator 1-alpha; PPARGC 1 alpha; PPARGC-1-alpha; PPARGC1; PRGC1_HUMAN; OTTHUMP00000123372; ligand effect modulator-6; PGC-1v; PGC-1(alpha)
Cat.#:PPARGC1A-729HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPARGC1A Protein, His-tagged
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Cat.#:PPARGC1A-8291HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PPARGC1A protein, GST-tagged
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Cat.#:PPARGC1A-13163MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPARGC1A Protein
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Cat.#:Ppargc1a-8492MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ppargc1a protein, His-tagged
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Cat.#:PPARGC1A-4594RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ppargc1a protein, His-tagged
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Involved Pathway

PPARGC1A involved in several pathways and played different roles in them. We selected most pathways PPARGC1A participated on our site, such as AMPK signaling pathway, Insulin signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPARGC1A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AMPK signaling pathway
PPP2R5C; MLYCD; PFKFB1; PFKM; G6PC; MTOR; CPT1B; PFKL; CREB3L4; PCK1
Insulin signaling pathway
AKT3A; PRKAG1; AKT2; CBL; PIK3CA; PKLR; SHC2; MKNK2A; PHKG1B; IRS1
Adipocytokine signaling pathway
RXRAA; ADIPOR1B; MTOR; IKBKG; LEP; NFKBIAA; SLC2A1; ACSL1B; ADIPOQ; AKT1
Glucagon signaling pathway
PRKACB; PRKAB2; PKM; FOXO1; PYGM; AKT2; PPARGC1A; GCG; PLCB2; CREB3L2
Insulin resistance
PTENB; NFKB1; PPP1R3C; PTPN11B; NFKBIAB; PRKCZ; PIK3CB; MGEA5; G6PCA.2; GFPT2
Huntingtons disease
NDUFA5; SDHD; NDUFV1; DCTN1; GRM5; POLR2J; NDUFA1; DNAH6; PLCB2; NDUFB4

Protein Function

PPARGC1A has several biochemical functions, for example, DNA binding, RNA binding, RNA polymerase II transcription cofactor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPARGC1A itself. We selected most functions PPARGC1A had, and list some proteins which have the same functions with PPARGC1A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein SIX6B; ZNF143; NR2F1A; ZBTB39; ARXA; H2BFWT; IRX5A; ZNF705B; ISL2; ZFAND6
Function RNA binding
Related Protein SAMD4; HNRNPK; ZNF385B; EIF4G2A; RPL24; PUSL1; CPSF1; ZNF385C; ENDOU2; RPS14
Function RNA polymerase II transcription cofactor activity
Related Protein PPRC1; MED8; PPARGC1A; MED11; MED21; MED12; MED14; MED18; TDG; MED15
Function alpha-tubulin binding
Related Protein WASH; TRPV4; PROL1; CAV3; HDAC6; INO80; SPAST; ARL4C; B4GALT1; ARL8A
Function chromatin DNA binding
Related Protein HIST1H1E; ACTN4; H2AFY; THRA; HIST1H1A; SRF; CLOCK; THRB; HIST1H1D; RELA
Function chromatin binding
Related Protein Ar; PCNA; YBX2; CDK9; SMAD4; DNAJC2; MPO; ARID5A; EGFR; MSL1
Function estrogen receptor binding
Related Protein PPARGC1A; TMEM38A; DYX1C1; PPARG; NRIP1; XBP1; NSD1; PCNA; PHB2; FOXL2
Function ligand-dependent nuclear receptor binding
Related Protein BAZ2A; TADA3; MED1; UBA3; SMARCD3; NCOR1; NCOR2; NCOA1; TRIP4; PROX1
Function ligand-dependent nuclear receptor transcription coactivator activity
Related Protein PPRC1; SFR1; CARM1; CCAR1; PRKCBB; ZMIZ2; ATXN7L3; PUS1; NCOA3; USP22
Function nucleic acid binding
Related Protein DHX36; ZNF143A; KCNH7; C19orf6; TRNAU1APB; SP5L; CIZ1; Akap17b; AGO3B; ZFY1
Function nucleotide binding
Related Protein CSNK1DA; GMPPAB; MAPKAPK2B; SRSF2A; ATP1A1A.3; MYO10; VMHC; ULK1A; CAMKK1A; PRTFDC1
Function peroxisome proliferator activated receptor binding
Related Protein NFATC4; ASXL1; HMGA1; EP300; CREBBP; MED1; NR0B2; ASXL2; HMGA1-RS1; IKBKG
Function promoter-specific chromatin binding
Related Protein PPARGC1A
Function protein binding
Related Protein S100A2; RPL7A; XPO1; TRIM3; CCNF; HSD17B8; UROD; RBP4; MECOM; STOM
Function sequence-specific DNA binding
Related Protein ATF7B; ARGFX; TFAP2B; NR4A2A; SALL3B; CAMTA1; FOXI2; FOXK2; NFYBA; SOX14
Function transcription coactivator activity
Related Protein ENY2; SOX17; JUNBA; PARK7; KDM5A; TRIP4; MLL5; MED27; PIAS2; RIPK3
Function transcription factor binding
Related Protein KCNA3; PRKDC; RNF4; NFYC; PPARG; FOXA3; CREBBP; FOS; MYOD1; FLNA
Function ubiquitin protein ligase binding
Related Protein RRAGA; NAE1; BAG6; TANK; PER1; USP2; TRAF2; DERL1; RB1; UBE2KA

Interacting Protein

PPARGC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPARGC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPARGC1A.
Sirt1; Irf4; Lrpprc; LRPPRC; IQGAP1; EP300; SIRT1; NR1I2