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PPHLN1

Official Full Name

periphilin 1
Overview

The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms

PPHLN1; periphilin 1; periphilin-1; Gastric cancer antigen Ga50; PPHLN_HUMAN; OTTHUMP00000241107; OTTHUMP00000241108; OTTHUMP00000241109; OTTHUMP00000241110; OTTHUMP00000241113; OTTHUMP00000241114; OTTHUMP00000241115; OTTHUMP00000241116; OTTHUMP00000241117; OTTHUMP00000241118; HSPC206; HSPC232;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His|T7
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPHLN1-28673TH	Recombinant Human PPHLN1, His-tagged	E.coli	His		Inquiry
Human	PPHLN1-2976HCL	Recombinant Human PPHLN1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PPHLN1-961H	Recombinant Human PPHLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	Pphln1-8036M	Recombinant Mouse Pphln1 protein, His & T7-tagged	E.coli	His/T7	Met1~Phe381 (Accession # Q8K2H1)	Inquiry
Mouse	Pphln1-5037M	Recombinant Mouse Pphln1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	PPHLN1-5012Z	Recombinant Zebrafish PPHLN1	Mammalian Cell	His		Inquiry
Chicken	PPHLN1-2438C	Recombinant Chicken PPHLN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PPHLN1 Related Articles

PPHLN1 involved in several pathways and played different roles in them. We selected most pathways PPHLN1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PPHLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PPHLN1 has several biochemical functions, for example, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPHLN1 itself. We selected most functions PPHLN1 had, and list some proteins which have the same functions with PPHLN1. You can find most of the proteins on our site.

Function	Related Protein
poly(A) RNA binding	NIP7;DDX42;RBM25;GNL3L;AGO2;SLC16A3;SNRPB;Cstb;ZFC3H1
protein binding	GSE1;IGF1;FAM19A1;PPP2R3C;CEP152;VPS33A;KCNG3;RWDD1;CCS

PPHLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPHLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPHLN1.

CCDC57; MTUS2; TSGA10; SNCAIP; CDK6; VIM; BCL2L1; SQSTM1; TP53BP2; TOMM20; CDC37; rpoD; SEPT8

Ludin, P; Nilsson, D; et al. Genome-Wide Identification of Molecular Mimicry Candidates in Parasites. PLOS ONE 6:-(2011).

Soehn, AS; Franck, T; et al. Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease. NEUROGENETICS 11:203-215(2010).