ppm1b
Share
  • Official Full Name
  • protein phosphatase, Mg2+/Mn2+ dependent, 1B
  • Background
  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
  • Synonyms
  • PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B; protein phosphatase 1B (formerly 2C), magnesium dependent, beta isoform; protein phosphatase 1B; PP2CB; PP2CBETA; PPC2BETAX; protein phosphatase 2C; beta isoform; PP2C-beta; protein phosphatase 2C isofo
Cat.#:PPM1B-1894HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPM1B, GST-tagged
+Inquiry
Cat.#:PPM1B-79HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human PPM1B protein, His-tagged
+Inquiry
Cat.#:PPM1B-3552RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPM1B Protein, His-tagged
+Inquiry
Cat.#:PPM1B-2732CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPM1B
+Inquiry
Cat.#:PPM1B-2962HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PPM1B 293 Cell Lysate
+Inquiry
Cat.#:PPM1B-2963HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PPM1B 293 Cell Lysate
+Inquiry

Involved Pathway

PPM1B involved in several pathways and played different roles in them. We selected most pathways PPM1B participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ARRB2B; MAPK6; PDGFAA; SRF; HSPA8; DDIT3; TAB2; FGFR2; ELK1; NTF4

Protein Function

PPM1B has several biochemical functions, for example, magnesium ion binding, manganese ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1B itself. We selected most functions PPM1B had, and list some proteins which have the same functions with PPM1B. You can find most of the proteins on our site.
Function
Related Protein
Function magnesium ion binding
Related Protein ADPRH; MARK2; MTPAP; PSPH; ADPRHL1; EYA2; SRR; PINK1; STK38L; MAPK12
Function manganese ion binding
Related Protein DCP2; PRIMPOL; PIM1; PPM1M; MPPE1; LAP3; GALNT3; HMGCL; NPEPL1; PPM1B
Function protein binding
Related Protein ETS2; VIP; LSM2; JUND; EIF2B4; IQSEC3; TSPO; CDC27; STX8; PGBD1
Function protein serine/threonine phosphatase activity
Related Protein PPM1BA; PPM1DB; PPM1F; UBLCP1; CTDNEP1A; PPM1N; PPP4C; TIMM50; MTMR3; PPM1H

Interacting Protein

PPM1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1B.
ARRB2; ISG15; ARRB1; Tcr-alpha; Smurf2; CHUK; RASGRP1; FOS; ANXA1; S100A8; KRT18; GSN; ANXA2