PPP3CA
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Official Full Name
protein phosphatase 3, catalytic subunit, alpha isozyme
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Overview
Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B).It activates the T cells of the immune system and can be blo -
Synonyms
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme; CALN, CALNA, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); serine/thr;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- CHO
- E.coli
- HEK293
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21 Insect Cell
- Fc
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PPP3CA Related Research Area
PPP3CA involved in several pathways and played different roles in them. We selected most pathways PPP3CA participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | HRAS;PAK1;AKT3A;RASA1;FGF8A;MKNK2;MAPK9;MAPK4;RRAS |
| Calcium signaling pathway | SLC8A4A;CHRM5;GRIN2C;PPP3R1B;RYR2;AGTR1B;ADRA1BB;BDKRB1;VDAC2 |
| cGMP-PKG signaling pathway | NPR2;ATP1A3;Adcy4;SLC8A1;PPP1R12A;BDKRB2;PPP1CA;VASP;BAD |
| Oocyte meiosis | ESPL1;BUB1;PLK1;PPP2R5B;RPS6KA3;PPP2R5EA;PPP1CA;PPP3R1B;ANAPC4 |
| Apoptosis | BAX;RELA;NFKBIAA;ENDOG;MYD88;CDK5RAP2;SATB1;DSG2;DSG1 |
| Wnt signaling pathway | FBXW11B;RHOA;CACYBP;VANGL1;PPP3CA;WNT7AA;CTNNBIP1;PRKACBA;WNT1 |
| Axon guidance | ARHGEF12;SLIT1;PPP3CC;SEMA6C;RHOAE;CFL2;ROCK2;COL9A3;RAC1 |
| VEGF signaling pathway | PTGS2A;PLA2G4AA;PTK2;BAD;PIK3CA;RAC3B;RAC3;RAC1;MAP2K1 |
| Osteoclast differentiation | LILRA5;NFKBIA;PPP3R1;LILRB5;NOX1;TGFB1;PPP3CB;OSCAR;FCGR3A |
| Natural killer cell mediated cytotoxicity | NCR2;KIR2DL3;KLRC3;SYK;TNFSF10;PIK3CD;KIR3DL1;LAT;NRAS |
| T cell receptor signaling pathway | NFATC1;IL4;LCP2;NFATC2;DBNLB;IL5;MAPK1;VAV1;ZAP70 |
| B cell receptor signaling pathway | CR2;PPP3R2;RAP2A;GRB2;ARPC5;CSK;BANK1;RAC2;ARPC4 |
| Long-term potentiation | RPS6KA3;PRKCG;BRAF;GRIN2D;RAP1A;RPS6KA1;MAPK3;CAMK4;ATF4 |
| Glutamatergic synapse | GNAQ;SHANK2;MAPK1;PRKACB;GNB2;GRIK5;HOMER1;GRIK1;SLC17A6 |
| Dopaminergic synapse | DRD5;MAPK13;SLC6A3;AKT1;PPP2R3C;GNB2;KCNJ9;CALM1;PPP2R1B |
| Oxytocin signaling pathway | PIK3CB;PIK3CD;RGS2;CACNA2D4;ROCK1;GUCY1B3;PRKACG;MAP2K1;PPP3R1 |
| Renin secretion | PLCB3;GNAI1;PRKACG;PRKACA;NPR1;PDE1B;PRKACB;PPP3R2;CLCA5 |
| Alzheimers disease | NDUFB4;SDHC;CALM2;CDK5R1;NDUFAB1;CALML5;ITPR2;GAPDH;PPP3CA |
| Amyotrophic lateral sclerosis (ALS) | BID;CASP12;RAC1;DERL1;MAPK11;BAX;PPP3CC;TNFRSF1A;NOS1 |
| Tuberculosis | KSR1;CLEC4M;ATP6V0D1;IFNA21;NOS2;FCGR1;CAMP;PPP3R2;CALM3 |
| HTLV-I infection | NRAS;HRAS;RELA;TP53;WNT5B;NRP1;HLA-F;MAP2K4;LCK |
PPP3CA has several biochemical functions, for example, calcium ion binding, calmodulin binding, calmodulin-dependent protein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CA itself. We selected most functions PPP3CA had, and list some proteins which have the same functions with PPP3CA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDH1G22;PCDH10A;GRM7;AMY2A;MMP1;PCDHB6;PCDH2G6;EMR2;TBC1D9 |
| calmodulin binding | KCNN1A;MKNK2B;CALD1B;MAPKAPK2A;KCNN1B;CNN1;MARCKS;SPTBN1;ITPKC |
| calmodulin-dependent protein phosphatase activity | PPM1F;PPP3CA;PPM1A;PPP3CB |
| drug binding | SMO;CHRM1;SRP54A;CHRNA2;DRD1A;FOLR2;P2RX4;ABP1;CHRNB4 |
| enzyme binding | MAPK8;PYCARD;ZFHX3;POR;RPA2;UGT1A6B;TAL1;STUB1;CYP2C8 |
| protein binding | MED15;G0S2;COMMD7;GAK;THOC1;PTTG1;C9orf16;HSPA13;GTF2A1 |
| protein dimerization activity | HIF3A;ARNTL1B;MYO5A;MSGN1;NEUROD6B;HER6;LDB1A;POLR1D;PEX3 |
| protein heterodimerization activity | HIF1A;PPP2R1A;MTTP;CAV1;MAFG;AOC3;Fzd4;H2AFY;HIST1H4B |
| protein serine/threonine phosphatase activity | PPM1B;CDC14B;LCK;PPP5C;CTDNEP1;PPP4C;PPM1L;UBLCP1;PPM1LA |
PPP3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CA.
PPP3R1; GRB2; C16orf74; Cacng8; USP14; LASP1; Kcnj8; Nfatc1; ABL1
- Q&As
- Reviews
Q&As (4)
Ask a questionPPP3CA is highly expressed in lung, brain and testis.
PPP3CA is closely related to breast cancer and reproductive processes and other studies.
PPP3CA is involved in processes related to cell growth and development, immune response, and spermatogenesis.
TRIM72 interacts with PPP3CA.
Customer Reviews (3)
Write a reviewGood value for money and worth the price!
The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.
The proteins purchased from your company are of very high quality and are suitable for WB experiments.
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