pqbp1
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  • Official Full Name
  • polyglutamine binding protein 1
  • Background
  • This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
  • Synonyms
  • PQBP1; polyglutamine binding protein 1; mental retardation, X linked 55 , MRX55, MRXS8, RENS1, SHS, Sutherland Haan X linked mental retardation syndrome; polyglutamine-binding protein 1; 38 kDa nuclear protein containing a WW domain; Mental retardation, X linked 55; MRX55; MRXS3; MRXS8; Npw38; Nuclear protein containing WW domain 38 kD; OTTHUMP00000025808; Polyglutamine tract binding protein 1; PQBP 1; RENS1; SHS; Sutherland Haan X linked mental retardation syndrome; PQBP-1; OTTHUMP00000025809; OTTHUMP00000025812; polyglutamine tract-binding protein 1
Cat.#:PQBP1-1933HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PQBP1, His-tagged
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Cat.#:PQBP1-6773HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Polyglutamine Binding Protein 1, His-tagged
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Cat.#:PQBP1-4651RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PQBP1 Protein
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Cat.#:PQBP1-3584RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PQBP1 Protein, His-tagged
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Cat.#:PQBP1-568ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PQBP1
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Cat.#:PQBP1-2903HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PQBP1 293 Cell Lysate
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Involved Pathway

PQBP1 involved in several pathways and played different roles in them. We selected most pathways PQBP1 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PQBP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
AQR; DHX8; PUF60A; DDX5; SNRPG; SF3A2; HNRPK; SNRPD3L; SRSF4; SNRPA

Protein Function

PQBP1 has several biochemical functions, for example, DNA binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PQBP1 itself. We selected most functions PQBP1 had, and list some proteins which have the same functions with PQBP1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein NKX2.3; POLR1D; MAP1S; ZBTB2; H3F3B.1; TBX24; ZNF444; FAM60AL; ZNF354A; ZNF580
Function protein C-terminus binding
Related Protein TOP2B; JAK2; YEATS4; CTNNB1; C11orf60; DDX1; AP2A1; CEP120; PABPC1; FOXN3
Function protein binding
Related Protein MAPK13; JMJD6; EGF; ZSCAN16; FAN1; KIF4A; AIRE; RXRB; MXD4; HIST1H2BF
Function ribonucleoprotein complex binding
Related Protein IFIH1; RNF135; PRMT7; RNASEL; PITX2; WDR12; YBX2; CKAP5; CD2BP2; PRPF6
Function transcription coactivator activity
Related Protein WNT3A; SUPT3H; TAF7; MED27; NCOA1; MAX; JUN; NFKB2; BCL10; MMS19

Interacting Protein

PQBP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PQBP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PQBP1.
WBP11; GOLGA2; MAPRE1; LZTS2; SF3A2; AQR; CLTB; RCVRN; HNRNPH2; RAB8A; EEF1A1; RIF1

PQBP1 Related Articles

Hoop, CL; Lin, HK; et al. Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance. BIOCHEMISTRY 53:6653-6666(2014).
Cui, XT; Liang, QN; et al. TR-FRET Assays of Huntingtin Protein Fragments Reveal Temperature and PolyQ Length-Dependent Conformational Changes. SCIENTIFIC REPORTS 4:-(2014).