prf1
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  • Official Full Name
  • perforin 1 (pore forming protein)
  • Background
  • The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PRF1; perforin 1 (pore forming protein); P1; PFP; FLH2; PFN1; HPLH2; perforin-1; cytolysin; lymphocyte pore forming protein; lymphocyte pore-forming protein;
Cat.#:PRF1-1931MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PRF1 Protein (21-554 aa), His-tagged
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Cat.#:PRF1-738RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat PRF1 Protein (25-554 aa), His-tagged
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Cat.#:PRF1-158HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRF1 protein, His-tagged
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Cat.#:PRF1-1942HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRF1, His-tagged
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Cat.#:PRF1-25HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRF1 protein, His/GST-tagged
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Cat.#:PRF1-29996THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRF1
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Cat.#:PRF1-30288THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRF1
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Cat.#:PRF1-326HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRF1
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Cat.#:Prf1-25MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prf1 protein, His/GST-tagged
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Cat.#:Prf1-6804RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prf1 protein, His & T7-tagged
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Cat.#:PRF1-55HTag:
Source (Host):Species:Human
Product nameNative Human Perforin
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Cat.#:PRF1-2873HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRF1 293 Cell Lysate
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Involved Pathway

PRF1 involved in several pathways and played different roles in them. We selected most pathways PRF1 participated on our site, such as Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Autoi, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Natural killer cell mediated cytotoxicity
SH2D1A; NRAS; PIK3R3; KIR2DS2; KIR2DS5; PPP3CB; PLCG2; NCR2; FCGR4; PPP3R2
Type I diabetes mellitus
TNF; HLA-DOA; GZMB; INS2; HLA-DRB5; HLA-DMB; PRF1; HLA-A; HLA-DRB3; IL12B
Autoi
H2-AB1; GZMB; IL5; HLA-G; IFNA14; Il2; HLA-B; TPO; IFNA8; CD40LG
ne thyroid disease
H2-Q10; TG; FAS; TSHB; HLA-DQA1; HLA-DMA; Ifna11; CD40; HLA-DOA; IFNA1
Allograft rejection
GZMB; Il2; MICA; H2-Q10; HLA-DMB; HLA-DRB5; HLA-DRB4; HLA-DRA; HLA-DQB1; IL12B
Graft-versus-host disease
TNF; HLA-DPB1; HLA-A; HLA-G; FAS; CD28; KIR3DL1; KIR2DL1; IL1A; HLA-DPA1
Viral myocarditis
CAV1; HLA-DPB1; ICAM1; CD86; BID; EIF4G2; HLA-DPA1; CXADR; CD40LG; HLA-E

Protein Function

PRF1 has several biochemical functions, for example, calcium ion binding, protein binding, wide pore channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRF1 itself. We selected most functions PRF1 had, and list some proteins which have the same functions with PRF1. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein SYT6; S100A13; CDH17; CABP5B; MYLPFB; EGFL7; SULF2B; CMLC1; PCDH2G10; ITSN2
Function protein binding
Related Protein SLC52A2; ZC3HAV1; PFDN4; BCKDHA; PLCG2; NSMAF; MAGEA1; RPL30; MPP6; CLTC
Function wide pore channel activity
Related Protein PANX1B; PANX2; PRF1; PANX1A

Interacting Protein

PRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRF1.
KRT31; SRGN; GZMB; ompC; DDX24

PRF1 Related Articles

Balada, E; Castro-Marrero, J; et al. Clinical and serological findings associated with the expression of ITGAL, PRF1, and CD70 in systemic lupus erythematosus. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 32:113-116(2014).
Ceccarelli, F; D'Alfonso, S; et al. The role of eight polymorphisms in three candidate genes in determining the susceptibility, phenotype, and response to anti-TNF therapy in patients with rheumatoid arthritis. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 30:939-942(2012).