PRF1
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Official Full Name
perforin 1 (pore forming protein)
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Overview
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] -
Synonyms
PRF1; perforin 1 (pore forming protein); P1; PFP; FLH2; PFN1; HPLH2; perforin-1; cytolysin; lymphocyte pore forming protein; lymphocyte pore-forming protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Human Cytotoxic Granules of YT Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Wheat Germ
- Yeast
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- SUMO
- MBP
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PRF1-29996TH | Recombinant Human PRF1 | Wheat Germ | N/A | 95 amino acids | |
Human | PRF1-25H | Recombinant Human PRF1 protein, His/GST-tagged | E.coli | His/GST | ||
Human | PRF1-326H | Recombinant Human PRF1 | Mammalian Cell | His | ||
Human | PRF1-30288TH | Recombinant Human PRF1 | Wheat Germ | N/A | 534 amino acids | |
Human | PRF1-1942H | Recombinant Human PRF1, His-tagged | E.coli | His | 247-555aa | |
Human | PRF1-158H | Recombinant Human PRF1 protein, His-tagged | E.coli | His | Pro22~Trp555 | |
Human | PRF1-2873HCL | Recombinant Human PRF1 293 Cell Lysate | HEK293 | N/A | ||
Human | PRF1-2252H | Recombinant Human PRF1 protein, MBP&His-tagged | Insect Cell | MBP&His | 22-555aa | |
Human | PRF1-3904H-B | Recombinant Human PRF1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | PRF1-26H | Recombinant Human PRF1 protein, His-SUMO-tagged | E. coli | His-SUMO | 22-555aa | |
Human | PRF1-3904H | Recombinant Human PRF1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | PRF1-55H | Native Human Perforin | Human Cytotoxic Granules of YT Cell | N/A | ||
Human | PRF1-5976H | Recombinant Human PRF1 Protein (Gln411-Gly531), N-His tagged | E.coli | N-His | Gln411-Gly531 | |
Human | PRF1-392HF | Recombinant Full Length Human PRF1 Protein | In Vitro Cell Free System | 534 amino acids | ||
Human | PRF1-01H | Recombinant Human PRF1 Protein, His-Tagged | E.coli | His | ||
Mouse | Prf1-25M | Recombinant Mouse Prf1 protein, His/GST-tagged | E.coli | His/GST | ||
Mouse | PRF1-1931M | Recombinant Mouse PRF1 Protein (21-554 aa), His-tagged | Yeast | His | 21-554 aa | |
Mouse | PRF1-3230M | Recombinant Mouse PRF1 protein, His-tagged | E.coli | His | Val40~Lys355 | |
Mouse | PRF1-192M | Recombinant Mouse PRF1 protein, His-tagged | E.coli | His | 21-554aa | |
Rat | Prf1-6804R | Recombinant Rat Prf1 protein, His & T7-tagged | E.coli | His/T7 | Ala120~Asp353 (Accession # P35763) | |
Rat | PRF1-738R | Recombinant Rat PRF1 Protein (25-554 aa), His-tagged | E.coli | His | 25-554 aa |
- Involved Pathway
- Protein Function
- Interacting Protein
- PRF1 Related Articles
- PRF1 Related Research Area
PRF1 involved in several pathways and played different roles in them. We selected most pathways PRF1 participated on our site, such as Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Autoi, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Natural killer cell mediated cytotoxicity | PIK3R3;PRKCB;CD244;PAK1;IFNA8;ICAM1;KIR2DS5;NRAS;KIR2DS2 |
Type I diabetes mellitus | INS1;HLA-DMB;IL1A;Fasl;HLA-A;PTPRN2;HLA-DPA1;HLA-DRA;HLA-DOB |
Autoi | HLA-DRB4;CD28;TPO;HLA-A;FAS;IFNA12;HLA-DQA2;GZMB;IFNA6 |
ne thyroid disease | HLA-DQB1;H2-AA;HLA-DQA2;CD80;CD40LG;CD28;TPO;FASLG;IL5 |
Allograft rejection | HLA-C;CD40;HLA-DRB5;HLA-DRB4;HLA-DOA;FAS;FASLG;HLA-DQA2;CD80 |
Graft-versus-host disease | HLA-C;HLA-DRB3;HLA-DRB5;HLA-DPB1;GZMB;CD80;HLA-E;KLRC1;H2-AA |
Viral myocarditis | HLA-DRA;CXADR;HLA-DRB1;ACTG1;CAV1;CD40;SGCD;H2-AA;HLA-DRB5 |
PRF1 has several biochemical functions, for example, calcium ion binding, protein binding, wide pore channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRF1 itself. We selected most functions PRF1 had, and list some proteins which have the same functions with PRF1. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | ALOX15B;SPNA1;S100A10B;VLDLR;S100A9;PCDH1GC6;SNCA;ANXA11;NID1 |
protein binding | CD5;LSAMP;SPDL1;TEC;SRSF1;C1orf105;SNX20;SEMA4A;TULP1 |
wide pore channel activity | PRF1;PANX2;PANX1B;PANX1A |
PRF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRF1.
KRT31; SRGN; GZMB; ompC; DDX24
- Q&As
- Reviews
Q&As (7)
Ask a questionSignaling pathways and stimuli such as T cell receptor (TCR) activation and exposure to infected cells influence the expression of perforin (PRF1) in immune cells.
PRF1 expression is particularly upregulated or modulated in cytotoxic immune cells such as cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells.
Dysregulation or abnormal expression of PRF1 is associated with conditions like hemophagocytic lymphohistiocytosis (HLH) and certain autoimmune disorders.
Perforin (PRF1) expression changes during immune activation, often being upregulated in response to various stimuli.
The balance between upregulation and downregulation of PRF1 is influenced by various factors, including the type of immune response and the microenvironment.
Altered PRF1 expression is significant for immune surveillance, as it plays a crucial role in the cytotoxicity of immune cells against infected or aberrant cells.
PRF1 contributes to immune responses by enabling immune cells to induce apoptosis in target cells, contributing to cytotoxicity.
Customer Reviews (3)
Write a reviewWe observed remarkable consistency in product performance across multiple batches, reducing variability in our experiments.
The manufacturer's history of producing high-quality products contributed to our trust in this protein.
Collaboration with other research groups was made easier by the product's standardized use in the scientific community.
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