prkaa2
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  • Official Full Name
  • protein kinase, AMP-activated, alpha 2 catalytic subunit
  • Background
  • The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a;heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important;energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is;activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy;beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and;cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin;sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
  • Synonyms
  • PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; PRKAA; 5-AMP-activated protein kinase catalytic subunit alpha-2; AMPK; AMPKa2; AMPK-alpha-2 chain; AMPK subunit alpha-2; 5-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK2
Cat.#:PRKAA2-105HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A2/B1/G1 subunits), His-tagged
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Cat.#:PRKAA2-145HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA2/PRKAB2/PRKAG1, His-tagged
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Cat.#:PRKAA2-362HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA2 protein, His/MBP-tagged
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Cat.#:PRKAA2-363HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA2 protein, His/MBP-tagged
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Cat.#:PRKAA2-364HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAA2 protein, His/MBP-tagged
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Cat.#:PRKAA2-43HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A2/B2/G1 subunits), GST-His-tagged
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Cat.#:PRKAA2-44HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (combination of A2/B2/G2 subunits), GST-His-tagged
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Cat.#:PRKAA2-60HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKAA2 (A2/B2/G3), GST-His-tagged
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Cat.#:PRKAA2-73HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKAA2, GST-tagged
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Cat.#:PRKAA2-78HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A2/B1/G2), GST-His-tagged
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Cat.#:PRKAA2-79HTag:GST/His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AMPK (A2/B1/G3), GST-His-tagged
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Cat.#:PRKAA2-13349MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKAA2 Protein
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Cat.#:PRKAA2-4669RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAA2 Protein
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Cat.#:PRKAA2-3401CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAA2
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Cat.#:PRKAA2-1413HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKAA2 cell lysate
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Involved Pathway

PRKAA2 involved in several pathways and played different roles in them. We selected most pathways PRKAA2 participated on our site, such as FoxO signaling pathway, Regulation of autophagy, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
USP7; GABARAPL2; MAPK12A; CCND2A; IGF1RA; MAP2K2B; GRB2; INSB; EP300; AGAP2
Regulation of autophagy
PRKAA2; IFNA2; ATG4A; GABARAPL1; ATG3; ULK3; ATG16L1; IFNA6; ULK2; GABARAP
mTOR signaling pathway
RPTOR; PIK3R5; CAB39; EIF4BB; PDPK1B; RRN3; PRKAA1; AKT2; RRAGD; PRKCG
PIK-Akt signaling pathway
SOS1; NGFR; TNXB; CREB3L2; LAMC1; PCK1; FGFR1; LAMA4; PKN3; DDIT4
AMPK signaling pathway
PRKAA2; RAB14; ADIPOR2; PRKAB2; STRADB; HMGCR; FBP2; EEF2; EIF4EBP1; PPP2R3C
Circadian rhythm
RORA; ARNTL; CRY1; RBX1; RORB; NPAS2; PRKAG2; PER3; FBXL3; CUL1
Insulin signaling pathway
PRKAR2AA; SREBF1; PYGM; RAF1A; MAPK9; BAD; TSC1B; GRB2; PRKACAA; RPS6KB1B
Adipocytokine signaling pathway
PPARAB; PRKAG2; PRKAG3B; IRS2; PRKAA2; AKT2L; CAMKK1; STK11; TRADD; JAK2B
Oxytocin signaling pathway
CACNG6; GNAI2; MYL6; PRKAB2; PRKAG1; PTGS2; PRKCA; MEF2C; PRKAG2; CACNG7
Glucagon signaling pathway
PHKA1; PCK1; PDHA2; PYGL; CAMK2D; SLC2A1; AKT1; PLCB3; PDHA1; LDHAL6A
Insulin resistance
PDPK1; RPS6KA6; PTPN11A; GFPT2; SOCS3B; GYS2; PTPRF; PRKAG2; TNF; PPP1R3A
Non-alcoholic fatty liver disease (NAFLD)
COX6A2; RELA; INS; NDUFB8; XBP1; NDUFA10; NDUFA6; PIK3CB; UQCRC2; NDUFB10
Hypertrophic cardiomyopathy (HCM)
ITGA5; ITGA1; ITGA8; SGCA; PRKAG3; TGFB3; CACNG6; TPM1; ITGA10; ITGA2

Protein Function

PRKAA2 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, [acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA2 itself. We selected most functions PRKAA2 had, and list some proteins which have the same functions with PRKAA2. You can find most of the proteins on our site.
Function
Related Protein
Function AMP-activated protein kinase activity
Related Protein PRKAA1; PRKAB1; PRKAA2; PRKAG2; PRKAG3; ALPK2
Function ATP binding
Related Protein CAMKVB; SNRKB; MOCS3; PRKAG3; DDX5; PIM1; PANK3; ACSM4; GK; MYO5B
Function [acetyl-CoA carboxylase] kinase activity
Related Protein PRKAA2; PRKAA1
Function [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
Related Protein PRKAA1; PRKAA2
Function chromatin binding
Related Protein DLX3; LHX2; POLR2B; CCDC111; MLH3; ARX; MNT; FOSL2; PLAC8; PBX2
Function histone serine kinase activity
Related Protein AURKB; AURKC; PRKAA2; ATM; AURKA; PRKAA1
Function metal ion binding
Related Protein ZNF83; Scd1; RXRGB; KLK4; NUDT15; ZNF295; ZNF785; THAP4; ACY3.1; NUDT13
Function protein binding
Related Protein MOS; RCN2; PFN2; THAP10; FASLG; HERPUD1; JAM3B; ATP6V1E1; STOM; PSMD11
Function protein kinase activity
Related Protein RIPK1L; PRKG2; CHEK1; GUCY2F; SRPK1A; RIPK4; KITA; MAPK8B; EPHA1; CCL5
Function protein serine/threonine kinase activity
Related Protein PRKCQ; RPS6KA3A; MAPKAPK2; TESK1; CDK1; NEK10; MAPK8; DYRK1A; TESK2; CHEK2
Function protein serine/threonine/tyrosine kinase activity
Related Protein DYRK1AA; CLK4; TNK2; PRKAA2; CLK1; DYRK4; AKT1; DSTYK; DYRK3; ACVR2B

Interacting Protein

PRKAA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA2.
PRKAB2; PRKAG1; KIFC3; 386682

PRKAA2 Related Articles

Bhavsar, SK; Schmidt, S; et al. AMPK alpha 1-Sensitivity of Orai1 and Ca2+ Entry in T-Lymphocytes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 32:687-698(2013).
Voss, M; Paterson, J; et al. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. CELLULAR SIGNALLING 23:114-124(2011).