prkab2
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  • Official Full Name
  • protein kinase, AMP-activated, beta 2 non-catalytic subunit
  • Background
  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.
  • Synonyms
  • PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit; 5-AMP-activated protein kinase subunit beta-2; AMPK beta 2; AMPK beta-2 chain; AMPK subunit beta-2; 5-AMP-activated protein kinase, beta-2 subunit; MGC61468
Cat.#:PRKAB2-427HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB2 Protein, His-tagged
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Cat.#:PRKAB2-1946HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB2, GST-tagged
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Cat.#:PRKAB2-237HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB2 protein, His-tagged
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Cat.#:PRKAB2-368HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB2 protein, His/MBP-tagged
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Cat.#:PRKAB2-369HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB2 protein, His/MBP-tagged
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Cat.#:PRKAB2-378HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human protein kinase, AMP-activated, beta 2 non-catalytic subunit, His-tagged
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Cat.#:PRKAB2-13351MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKAB2 Protein
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Cat.#:PRKAB2-4671RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAB2 Protein
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Cat.#:PRKAB2-3454CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAB2
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Cat.#:PRKAB2-7106ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKAB2
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Cat.#:PRKAB2-1414HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKAB2 cell lysate
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Involved Pathway

PRKAB2 involved in several pathways and played different roles in them. We selected most pathways PRKAB2 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
AKT2; TGFBR1A; PLK3; EP300; IRS2; MAPK12B; NLK; MAP2K2A; MAP2K2B; PIK3CD
AMPK signaling pathway
PFKFB1; PPP2R2C; PFKL; ULK1; PIK3R2; PIK3CG; PPP2R5E; IGF1R; IRS1; IGF1
Circadian rhythm
CRY2; PRKAA2; SKP1; RORC; NR1D1; RORA; BTRC; FBXL3; PRKAG1; ARNTL
Insulin signaling pathway
INPPL1A; IRS4; INS2; PRKCI; RAF1; PPP1R3CB; CALML3; FLOT1A; CALM2A; MTOR
Adipocytokine signaling pathway
STAT3; RELA; POMCA; IRS1; ADIPOR1B; MAPK10; RXRBA; SOCS3B; MAPK8B; TRADD
Oxytocin signaling pathway
CACNA2D2; PPP1CA; GUCY1A3; RCAN1; PRKAG1; OXTR; HRAS; MAPK7; MAPK3; CCND1
Glucagon signaling pathway
PHKA1; PKM; PCK2; LDHA; SLC2A1; PHKG2; AKT1; CAMK2D; CALM4; PRKAB2
Insulin resistance
PRKCB; PCK1; GFPT1; PDPK1B; G6PC3; CREB1A; SLC27A2; PPP1CC; SLC27A5; PRKCQ
Non-alcoholic fatty liver disease (NAFLD)
UQCRQ; NDUFA8; GSK3B; PRKAB1; BAX; PIK3R5; NDUFA11; NDUFB1; PRKAA1; NDUFB8
Hypertrophic cardiomyopathy (HCM)
PRKAB1; SGCD; CACNG4; IL6; ITGA1; ITGB8; TGFB3; ITGA6; TPM3; CACNA2D1

Protein Function

PRKAB2 has several biochemical functions, for example, contributes_to AMP-activated protein kinase activity, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAB2 itself. We selected most functions PRKAB2 had, and list some proteins which have the same functions with PRKAB2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to AMP-activated protein kinase activity
Related Protein PRKAG1; PRKAB2
Function identical protein binding
Related Protein MYOM1; DNMT3A; SCAND1; PRKAB2; CLDN11; SH3GL2; DPP4; MRFAP1L1; IK; GOT2A
Function protein binding
Related Protein FNTA; STBD1; LINGO1B; EIF2S2; WWP2; PSKH1; FAM118A; RAP1GDS1; ICAM3; GTPBP3

Interacting Protein

PRKAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAB2.
PRKAA1; PRKAG1; PRKAA2

PRKAB2 Related Articles

Sakabe, T; Tsuchiya, H; et al. Identification of the Genes Chemosensitizing Hepatocellular Carcinoma Cells to Interferon-alpha/5-Fluorouracil and Their Clinical Significance. PLOS ONE 8:-(2013).
Janecek, S; Svensson, B; et al. Structural and evolutionary aspects of two families of non-catalytic domains present in starch and glycogen binding proteins from microbes, plants and animals. ENZYME AND MICROBIAL TECHNOLOGY 49:429-440(2011).