PRKAG3
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Official Full Name
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
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Overview
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. -
Synonyms
PRKAG3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; 5-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK gamma-3 chain; AMPK subunit gamma-3; 5-AMP-activated protein kinase, gamma-3 subunit; AMPKG3;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PRKAG3-2863HCL | Recombinant Human PRKAG3 293 Cell Lysate | HEK293 | N/A |
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| Mouse | PRKAG3-13356M | Recombinant Mouse PRKAG3 Protein | Mammalian Cell | His |
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| Mouse | PRKAG3-7089M | Recombinant Mouse PRKAG3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Prkag3-426M | Recombinant Mouse Prkag3 Protein, His-tagged | E.coli | His | Val238~Val467 | |
| Mouse | PRKAG3-7089M-B | Recombinant Mouse PRKAG3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | PRKAG3-2916C | Recombinant Chicken PRKAG3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PRKAG3 Related Research Area
PRKAG3 involved in several pathways and played different roles in them. We selected most pathways PRKAG3 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | GADD45B;MAPK9;STK4;PRKAG3;PRKAG2A;INSB;FOXO4;IKBKB;INS |
| AMPK signaling pathway | CAB39;AKT2;CAMKK2;IRS1;ADIPOR2;CREB5;STRADB;PCK1;TSC1 |
| Circadian rhythm | PRKAA2;RORB;PRKAB1;RORC;PER1;ARNTL;PRKAG2;PER3;PRKAB2 |
| Insulin signaling pathway | PRKAG3;G6PCA.1;TRIP10;PDE3B;G6PC;PYGL;SH2B2;PRKAR2B;PRKACBB |
| Adipocytokine signaling pathway | PTPN11;ACSBG2;PRKAG3B;ADIPOR2;AKT1;POMCA;SLC2A1;ACSL4B;ACSL3A |
| Oxytocin signaling pathway | PPP1R12B;CACNG7;MEF2C;HRAS;MYL6;RYR3;CALM2;SRC;PLCB2 |
| Insulin resistance | FOXO1A;GFPT2;PRKCZ;PPP1CC;PRKAA2;RPS6KA6;SLC27A3;PDPK1B;MAPK8A |
| Non-alcoholic fatty liver disease (NAFLD) | AKT2;XBP1;NDUFS5;PRKAB2;ADIPOR2;PIK3R2;IL6;PIK3CA;NDUFA4 |
| Hypertrophic cardiomyopathy (HCM) | TNNC1;LMNA;PRKAG3;ITGAV;ITGA3;PRKAB2;CACNG7;MYL2;TGFB1 |
PRKAG3 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAG3 itself. We selected most functions PRKAG3 had, and list some proteins which have the same functions with PRKAG3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AMP-activated protein kinase activity | PRKAA2;PRKAG3;ALPK2;PRKAG2;PRKAA1;PRKAB1 |
| ATP binding | KCNJ11;ALDH18A1;HSPA4;CLPX;ROS1;cka1;GLUD1;ITM2C;CASK |
| protein kinase binding | ARHGEF7;MSH2;MAP3K5;TCF7L2;PLCG1;CDC25C;CCNB1;PAK2;DCX |
PRKAG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAG3.
Klc1; Klc2
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