prkag3
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  • Official Full Name
  • protein kinase, AMP-activated, gamma 3 non-catalytic subunit
  • Background
  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.
  • Synonyms
  • PRKAG3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; 5-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK gamma-3 chain; AMPK subunit gamma-3; 5-AMP-activated protein kinase, gamma-3 subunit; AMPKG3
Cat.#:Prkag3-426MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prkag3 Protein, His-tagged
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Cat.#:PRKAG3-13356MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKAG3 Protein
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Cat.#:PRKAG3-2916CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAG3
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Cat.#:PRKAG3-2863HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKAG3 293 Cell Lysate
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Involved Pathway

PRKAG3 involved in several pathways and played different roles in them. We selected most pathways PRKAG3 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
MAP2K2; FOXO3; SMAD2; IGF1; SETD7; INS2; STK11; BCL6; MAPK14B; BNIP4
AMPK signaling pathway
LEPR; HMGCR; PPP2R2D; STK11; CRTC2; CCND1; PFKP; CPT1B; PPP2R5C; PPP2R5D
Circadian rhythm
SKP1; CLOCK; CRY1; FBXL3; RBX1; RORC; BHLHE40; NR1D1; CRY2; RORA
Insulin signaling pathway
PTPRF; PRKAR1B; GRB2A; ARAF; RPTOR; SOCS3; GRB2B; MAPK10; PRKAR1AB; MTOR
Adipocytokine signaling pathway
NFKBIE; PCK2; PRKAB2; NFKBIB; ADIPOQB; PRKAB1; MTOR; PTPN11; RXRGA; ADIPOR1B
Oxytocin signaling pathway
PPP1CC; CACNG6; CAMK2G; ACTG1; PIK3CG; PRKACG; CALML3; NFATC3; CAMK2D; ITPR1
Glucagon signaling pathway
SMEK2; PRKACG; LDHA; CAMK2B; G6PC; FBP1; PFKFB1; CALM1; PPP3CC; PDHA1
Insulin resistance
PYGM; GYS1; SLC2A2; PIK3CG; NFKBIA; PIK3R3B; INSB; PTPN11B; RELA; MTOR
Non-alcoholic fatty liver disease (NAFLD)
ERN1; MAP3K5; PRKAA1; UQCRC1; NDUFS2; COX6B2; UQCRB; AKT2; NDUFA9; NDUFA13
Hypertrophic cardiomyopathy (HCM)
ITGB8; TPM4; ITGA3; CACNA2D3; CACNB1; IGF1; CACNG4; ITGA4; SGCG; LMNA

Protein Function

PRKAG3 has several biochemical functions, for example, AMP-activated protein kinase activity, ATP binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAG3 itself. We selected most functions PRKAG3 had, and list some proteins which have the same functions with PRKAG3. You can find most of the proteins on our site.
Function
Related Protein
Function AMP-activated protein kinase activity
Related Protein PRKAG3; PRKAB1; ALPK2; PRKAA1; PRKAG2; PRKAA2
Function ATP binding
Related Protein MCM4; PGS1; PIM1; RAD51L1; NEK3; GRK5; ABCC3; ATP2A3; BMPR2; SMARCA5
Function protein kinase binding
Related Protein YWHAZ; CAV1; EEF1A2; HNRNPA0; GHR; TRAF4; PRKACA; DNM2; ADCY6; MAP3K5

Interacting Protein

PRKAG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAG3.
Klc1; Klc2