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PROZ

Official Full Name

protein Z, vitamin K-dependent plasma glycoprotein
Overview

This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the;plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent;protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein;are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the;cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
Synonyms

PROZ; protein Z, vitamin K-dependent plasma glycoprotein; vitamin K-dependent protein Z; PZ; Protein Z, vitamin K dependent plasma glycoprotein; OTTHUMP00000018738; OTTHUMP00000018739;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PROZ-1419HCL	Recombinant Human PROZ cell lysate		N/A		Inquiry
Human	PROZ-6673H	Recombinant Human PROZ Protein (Thr282-Asn400), N-GST tagged	E.coli	N-GST	Thr282-Asn400	Inquiry
Human	PROZ-5470H	Native Human Protein Z, Vitamin K-Dependent Plasma Glycoprotein	Human plasma	N/A		Inquiry
Human	PROZ-2626H	Recombinant Human PROZ Protein, His-tagged	E.coli	N-His	Thr282-Asn400	Inquiry
Mouse	Proz-828M	Recombinant Mouse Proz protein, His & GST-tagged	E.coli	His/GST	Ser23~Lys399 (Accession # Q9CQW3)	Inquiry

Involved Pathway
Protein Function
Interacting Protein

PROZ involved in several pathways and played different roles in them. We selected most pathways PROZ participated on our site, such as Gamma carboxylation, hypusine formation and arylsulfatase activation, Gamma-carboxylation of protein precursors, Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROZ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Gamma carboxylation, hypusine formation and arylsulfatase activation	EIF5A;SUMF2;DPH5;DNAJC24;OTOP2;DHPS;WDR85;DPH1;DPH2
Gamma-carboxylation of protein precursors	PROZ;PROCA;GAS6;F9A;F9B
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	FURINA;FURINB;F9B;PROZ;PROCA;F9A;GAS6
Metabolism of proteins	CNIH2;MUCL1;NAT8B;KLHDC3;WIPI1;MAN1B1;YIF1A;ST8SIA3;MIA3
Post-translational protein modification	GALNTL5;ALG14;ADAMTS15;OTOP2;YKT6;DPAGT1;SMC6;SCFD1;TRAPPC3
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

PROZ has several biochemical functions, for example, calcium ion binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROZ itself. We selected most functions PROZ had, and list some proteins which have the same functions with PROZ. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PROS1;EFHC2;THBD;ANXA1;DGKB;KCNIP1B;HSP90B1;PVALB3;PEF1
serine-type endopeptidase activity	TMPRSS4A;C2;KLK15;KLK1B22;CTRB1;PRSS2;PRSS39;Gzmg;PRSS59.2

PROZ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROZ here. Most of them are supplied by our site. Hope this information will be useful for your research of PROZ.