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PRPF4

  • Official Full Name

    PRP4 pre-mRNA processing factor 4 homolog

  • Overview

    The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PRPF4; PRP4 pre-mRNA processing factor 4 homolog (yeast); U4/U6 small nuclear ribonucleoprotein Prp4; HPRP4; HPRP4P; PRP4; PRP4/STK/WD splicing factor; Prp4p; PRP4 homolog; WD splicing factor Prp4; U4/U6 snRNP 60 kDa protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRPF4-1976H Recombinant Human PRPF4, GST-tagged E.coli GST C-term-310aa
Human PRPF4-2825HCL Recombinant Human PRPF4 293 Cell Lysate HEK293 N/A
Human PRPF4-4811H Recombinant Human PRPF4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Prpf4-5147M Recombinant Mouse Prpf4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque PRPF4-3625R Recombinant Rhesus monkey PRPF4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRPF4-3443R Recombinant Rhesus Macaque PRPF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRPF4-3443R-B Recombinant Rhesus Macaque PRPF4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRPF4-10144Z Recombinant Zebrafish PRPF4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRPF4 Related Articles

PRPF4 involved in several pathways and played different roles in them. We selected most pathways PRPF4 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeSRSF5A;CTNNBL1;SNRNP27;SRSF7;SRSF4;DHX15;SNRNP200;SNRPC;SLU7

PRPF4 has several biochemical functions, for example, U4 snRNA binding, U6 snRNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF4 itself. We selected most functions PRPF4 had, and list some proteins which have the same functions with PRPF4. You can find most of the proteins on our site.

Function Related Protein
U4 snRNA bindingNHP2L1;PRPF4;PRPF31;DDX39B;SART3
U6 snRNA bindingLSM8;PRPF8;DDX39B;LSM7;SART3;LSM4;PRPF4;LSM2;RBM22
protein bindingESRP1;RPTOR;SPANXC;TRIM3;CTTNBP2NL;LOX;TRIM41;PTTG1;CLK4

PRPF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF4.

PPIH; SART1; PRPF3; PRPF6; PRPF4B; SART3; USP39; PRPF8; PRPF31

Linder, B; Hirmer, A; et al. Identification of a PRPF4 Loss-of-Function Variant That Abrogates U4/U6.U5 Tri-snRNP Integration and Is Associated with Retinitis Pigmentosa. PLOS ONE 9:-(2014).
Benaglio, P; San Jose, PF; et al. Mutational screening of splicing factor genes in cases with autosomal dominant retinitis pigmentosa. MOLECULAR VISION 20:843-851(2014).
  • Q&As
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