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PRPF6

Official Full Name

PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
Overview

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.
Synonyms

PRPF6; PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae); C20orf14, chromosome 20 open reading frame 14 , PRP6 pre mRNA processing factor 6 homolog (yeast); pre-mRNA-processing factor 6; ANT 1; bB152O15.1; Prp6; TOM; U5 102K; Androgen receptor N terminal domain transactivating protein 1; Chromosome 20 open reading frame 14; fc12b02; hypothetical protein LOC323855; p102 U5 small nuclear ribonucleoprotein particle binding protein; Pre mRNA processing factor 6; PRP6 homolog; PRPF 6; Putative mitochondrial outer membrane protein import receptor; U5 102 kDa protein; U5 snRNP associated 102 kDa protein; wu:fa05f07; wu:fc12b02; zgc:65913; U5-102 kDa protein; U5 snRNP-associated 102 kDa protein; androgen receptor N-terminal domain transactivating protein-1; androgen receptor N-terminal domain-transactivating protein 1; p102 U5 small nuclear ribonucleoprotein particle-binding protein; ANT1; ANT-1; hPrp6; U5-102K; C20orf14;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PRPF6-2823HCL	Recombinant Human PRPF6 293 Cell Lysate	HEK293	N/A	Inquiry
Human	PRPF6-01H	Recombinant Human PRPF6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Human	PRPF6-3647H	Recombinant Human PRPF6 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	PRPF6-13457M	Recombinant Mouse PRPF6 Protein	Mammalian Cell	His	Inquiry
Mouse	Prpf6-5149M	Recombinant Mouse Prpf6 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	PRPF6-7148M-B	Recombinant Mouse PRPF6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	PRPF6-7148M	Recombinant Mouse PRPF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rat	PRPF6-4721R	Recombinant Rat PRPF6 Protein	Mammalian Cell	His	Inquiry
Rat	PRPF6-4380R-B	Recombinant Rat PRPF6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rat	PRPF6-4380R	Recombinant Rat PRPF6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	PRPF6-11931Z	Recombinant Zebrafish PRPF6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PRPF6 Related Articles

PRPF6 involved in several pathways and played different roles in them. We selected most pathways PRPF6 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Spliceosome	SNRPC;AQR;XAB2;CHERP;SNRPB;SF3B4;PRPF31;SNRPF;TRA2B

PRPF6 has several biochemical functions, for example, RNA binding, androgen receptor binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPF6 itself. We selected most functions PRPF6 had, and list some proteins which have the same functions with PRPF6. You can find most of the proteins on our site.

Function	Related Protein
RNA binding	RBM4B;RBFOX1L;SF3B3;FXR1;C1D;CNP;RPL9;PPIE;RPL19
androgen receptor binding	RB1;BRCA1;DAXX;NSD1;WIPI1;FOXH1;FHL2;RAN;PRMT2
poly(A) RNA binding	SRSF4;MPHOSPH10;ANXA2;TNS1;CDK5R2;ARHGEF1;DDX54;DZIP3;SRSF11
protein binding	KLHDC5;RNF40;SNX7;Il4ra;LAIR1;MGST1;ARPC4;SNRPB2;NRL
ribonucleoprotein complex binding	PES;SRP54;PRPF6;PQBP1;TIMM50;PPIH;BOP1;IFIH1;ITCH
transcription coactivator activity	KAT2A;RAN;HINFP;PARK7;RBPMS;SERTAD2;THRAP3;BIRC2;SUPT7L

PRPF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPF6.

CD2BP2; MYC; PRPF4; RNPS1; IK; PRPF31; a8k1f4_human; SNRPB; SMARCA2; MDM2

Bhatia, V; Barroso, SI; et al. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2. NATURE 511:362-+(2014).

Derer, S; Till, A; et al. mTNF reverse signalling induced by TNF alpha antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease. GUT 62:376-386(2013).