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PRRX1

Official Full Name

paired related homeobox 1
Overview

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.
Synonyms

PRRX1; paired related homeobox 1; paired mesoderm homeo box 1 , PMX1; paired mesoderm homeobox protein 1; PHOX1; AGOTC; Homeobox protein PHOX1; Paired mesoderm homeo box 1; Paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired related homeobox protein 1; Paired-related homeobox protein 1; PHOX 1; PHOX1 1, 2; PMX 1; PMX1; PRRX 1; PRRX1_HUMAN; PRX 1; PRX-1; PRX1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E. coli
E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

C
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PRRX1-285H	Recombinant Human paired related homeobox 1, His-tagged	E.coli	His		Inquiry
Human	PRRX1-30707TH	Recombinant Human PRRX1	Wheat Germ	N/A	90 amino acids	Inquiry
Human	PRRX1-31000TH	Recombinant Human PRRX1	Wheat Germ	N/A	217 amino acids	Inquiry
Human	PRRX1-317H	Recombinant Human PRRX1	Mammalian Cell	His		Inquiry
Human	PRRX1-2807HCL	Recombinant Human PRRX1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PRRX1-427HF	Recombinant Full Length Human PRRX1 Protein	In Vitro Cell Free System		217 amino acids	Inquiry
Human	PRRX1-3924H	Recombinant Human PRRX1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	PRRX1-3924H-B	Recombinant Human PRRX1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	PRRX1-2787H	Recombinant Human PRRX1 protein(11-80 aa), C-His-tagged	E. coli	C-His	11-80 aa	Inquiry
Mouse	Prrx1-5162M	Recombinant Mouse Prrx1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	PRRX1-4735R	Recombinant Rat PRRX1 Protein	Mammalian Cell	His		Inquiry
Rat	PRRX1-4394R-B	Recombinant Rat PRRX1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PRRX1-4394R	Recombinant Rat PRRX1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	PRRX1-1747C	Recombinant Chicken PRRX1	Mammalian Cell	His		Inquiry
Chicken	PRRX1-5096C	Recombinant Chicken PRRX1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PRRX1 Related Articles

PRRX1 involved in several pathways and played different roles in them. We selected most pathways PRRX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRRX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PRRX1 has several biochemical functions, for example, HMG box domain binding, RNA polymerase II transcription coactivator activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRRX1 itself. We selected most functions PRRX1 had, and list some proteins which have the same functions with PRRX1. You can find most of the proteins on our site.

Function	Related Protein
HMG box domain binding	MEOX1;POU3F3;OLIG2;SP1;HOXA3;UTF1;JUN;PAX3;PRRX1
RNA polymerase II transcription coactivator activity	MKL1B;NCOA1;CITED2;RERE;POU1F1;NEUROD1;MKL1;SOX4;MYOCD
sequence-specific DNA binding	DLX6A;MNX2A;NR1D1;SIX1B;ZNF238;FOXD4;TBX5A;TAF2;TEF
transcription coactivator activity	BRD7;CCNE1;SMARCB1;MED7;STIL;YAP1;DYRK1B;HIF3A;IL31RA

PRRX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRRX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRRX1.

Nanez, A; Ramos, IN; et al. A Mutant Ahr Allele Protects the Embryonic Kidney from Hydrocarbon-Induced Deficits in Fetal Programming. ENVIRONMENTAL HEALTH PERSPECTIVES 119:1745-1753(2011).

Perco, P; Blaha, P; et al. Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade. TRANSPLANT INTERNATIONAL 19:146-157(2006).