PSMA1
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Official Full Name
proteasome (prosome, macropain) subunit, alpha type, 1
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Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
PSMA1; proteasome (prosome, macropain) subunit, alpha type, 1; proteasome subunit alpha type-1; HC2; MGC1667; MGC14542; MGC14575; MGC14751; MGC21459; MGC22853; MGC23915; NU; PROS30; 30 kDa prosomal protein; HC 2; Macropain subunit C2; Macropain subunit nu; Multicatalytic endopeptidase complex subunit C2; PROS 30; PROS-30; Proteasome (prosome macropain) subunit alpha type 1; Proteasome alpha 1 subunit; Proteasome component C2; Proteasome nu chain; Proteasome subunit alpha type 1; Proteasome subunit alpha type I; Proteasome subunit nu; Protein P30 33K; PSA1_HUMAN; PSC 2; PSC2; PSMA 1; protein P30-33K; OTTHUMP00000231103; OTTHUMP00000237995; OTTHUMP00000237996; proteasome;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Rat
- Rhesus Macaque
- Staphylococcus Aureus
- Staphylococcus aureus (strain NCTC 8325 / PS 47)
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|SUMOstar
- N/A
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- PSMA1 Related Research Area
PSMA1 involved in several pathways and played different roles in them. We selected most pathways PSMA1 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMD13;PSMB7;PSMD4A;PSMA1;PSME1;PSMB11B;PSMD11;PSMC2;PSMD11B |
PSMA1 has several biochemical functions, for example, RNA binding, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMA1 itself. We selected most functions PSMA1 had, and list some proteins which have the same functions with PSMA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA binding | ADAD2;FUS;U2AF1L4;PAPOLA;HNRNPAB;ALYREF;RPLP2;TRIM32;NANOS1 |
| endopeptidase activity | CD46;PSMA1;PCSK6;AP1S2;KLK1B11;KLK1B26;ACE2;MMP12;NCSTN |
| protein binding | FRMPD1;MAP4K1;C16orf59;L3MBTL3;TAF2;RHOB;INTS7;SLC39A7;FOXR1 |
| threonine-type endopeptidase activity | PSMA4;PRSS50;PSMB6;PSMB10;PSMA7;PSMB9B;PSMB1;PSMA6B;PSMA2 |
PSMA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMA1.
PSMA7; PSMA3; PSMA2
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