psmc6
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  • Official Full Name
  • proteasome (prosome, macropain) 26S subunit, ATPase, 6
  • Background
  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
  • Synonyms
  • PSMC6; proteasome (prosome, macropain) 26S subunit, ATPase, 6; 26S protease regulatory subunit 10B; p42; 26S protease regulatory subunit S10B; 26S proteasome AAA-ATPase subunit RPT4; CADP44; P44; Proteasome 26S subunit ATPase 6; Proteasome subunit p42; PRS10_HUMAN; Rpt4; SUG2; OTTHUMP00000179002; OTTHUMP00000245246; conserved ATPase domain protein 44
Cat.#:PSMC6-418HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC6 Protein, His-tagged
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Cat.#:PSMC6-2024HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC6, GST-tagged
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Cat.#:PSMC6-259HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC6 Protein, His-tagged
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Cat.#:PSMC6-31225THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC6, T7 -tagged
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Cat.#:PSMC6-398HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMC6, T7-tagged
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Cat.#:PSMC6-13586MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PSMC6 Protein
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Cat.#:PSMC6-1633CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PSMC6
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Cat.#:PSMC6-1123ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSMC6
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Cat.#:PSMC6-2758HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMC6 293 Cell Lysate
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Involved Pathway

PSMC6 involved in several pathways and played different roles in them. We selected most pathways PSMC6 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMC6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteasome
IFNG; PSMD1; PSMC1B; SHFM1; PSMB9; PSME2; PSMB8; PSMB10; PSMC2; PSMB3
Epstein-Barr virus infection
EIF2AK3; MAPK10; TRP53; HLA-DRB5; RELA; PSMD4; HSPA1B; EIF2AK1; HLA-DPA1; RBPJL

Protein Function

PSMC6 has several biochemical functions, for example, ATP binding, ATPase activity, TBP-class protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMC6 itself. We selected most functions PSMC6 had, and list some proteins which have the same functions with PSMC6. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TTBK2; MYH13; CDC34; ADCY7; PBK; PFKM; ORC4L; IQCA1; ACACB; PDS5B
Function ATPase activity
Related Protein PSMC6; RALBP1; ATP13A3; OLA1; PSMC2; CHD1L; KIF22; ABCB4; INO80; ERCC3
Function TBP-class protein binding
Related Protein CAND1; TAF1L; BRF1B; HHEX; PSMC4; GTF2A2; PSMC3; PSMC1B; CAND2; PSMC1A
Function proteasome-activating ATPase activity
Related Protein PSMC4; PSMC3; PSMC5; PSMC1B; PSMC1A; PSMC2; PSMC6; PSMC1
Function protein binding
Related Protein USF2; C1orf216; YBX1; SOX6; PHYHIPL; ACYP2; GPAA1; PDLIM7; COMMD6; GSG2
Function protein binding, bridging
Related Protein SPRR1A; TNNT2A; CNTLN; GATAD2A; STX1A; SH2D1B; NEFH; DDX20; CBX5; RAD50

Interacting Protein

PSMC6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMC6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMC6.
PSMD9; PSMC3; PSMC5

PSMC6 Related Articles

Sjakste, T; Paramonova, N; et al. Juvenile Idiopathic Arthritis Subtype- and Sex-specific Associations with Genetic Variants in the PSMA6/PSMC6/PSMA3 Gene Cluster. PEDIATRICS AND NEONATOLOGY 55:393-403(2014).
Kim, HY; Byun, MJ; et al. A replication study of genome-wide CNV association for hepatic biomarkers identifies nine genes associated with liver function. BMB REPORTS 44:578-583(2011).