• Official Full Name
  • paraspeckle component 1
  • Background
  • This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.
  • Synonyms
  • PSPC1; paraspeckle component 1; FLJ10955; PSP1; paraspeckle protein 1; FLJ33554; DKFZp566B1447
Source (Host):HEK293Species:Human
Product nameRecombinant Human PSPC1 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSPC1, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PSPC1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PSPC1 Protein
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PSPC1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PSPC1
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSPC1
Source (Host):HEK293Species:Human
Product nameRecombinant Human PSPC1 lysate

Protein Function

PSPC1 has several biochemical functions, for example, core promoter binding, nucleotide binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSPC1 itself. We selected most functions PSPC1 had, and list some proteins which have the same functions with PSPC1. You can find most of the proteins on our site.
Related Protein
Function core promoter binding
Related Protein FOXO3; E2F3; GTF2B; NKX3-1; NEUROG3; RELB; GADD45A; E2F2; HDAC4; HDAC6
Function nucleotide binding
Related Protein MAPK14B; MYH8; RBM33; RBM6; Aatk; HNRNPA1A; CLK4B; PPP1R2P9; HNRNPABB; SRSF2B
Function poly(A) RNA binding
Related Protein HNRPLL; G3BP2; SF3B14; HIST1H4B; ALDH18A1; CCAR1; GAR1; RPL32; ZMAT3; RPS2
Function protein binding
Related Protein TEAD2; GUCY1B3; TAOK3; Cd79a, Cd79b; SAP18; HIST2H3C; CX3CL1; SWSAP1; SART1; CDKN1B
Function transcription regulatory region sequence-specific DNA binding
Related Protein KDM3A; NR5A1B; PER2; ARNTL; NR5A1; NFKB1; SUV39H2; ARNTL1A; CREB3L3; POU5F1

Interacting Protein

PSPC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSPC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSPC1.
NONO; 140258; NONO; KRT31

PSPC1 Related Articles

Gremlich, S; Damnon, F; et al. The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development. PLACENTA 35:44-49(2014).
Naganuma, T; Hirose, T; et al. Paraspeckle formation during the biogenesis of long non-coding RNAs. RNA BIOLOGY 10:456-461(2013).