PTF1A
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Official Full Name
pancreas specific transcription factor, 1a
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Overview
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. -
Synonyms
PTF1A; pancreas specific transcription factor, 1a; pancreas transcription factor 1 subunit alpha; bHLHa29; PTF1 p48; class II bHLH protein PTF1A; bHLH transcription factor p48; class A basic helix-loop-helix protein 29; pancreas-specific transcription fac;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|GST
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PTF1A-8039H | Recombinant Human PTF1A protein, His & GST-tagged | E.coli | His/GST | Gln177~Ser328 (Accession # Q7RTS3) |
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| Human | PTF1A-8038H | Recombinant Human PTF1A protein, His-tagged | E.coli | His | Gln177~Ser328 |
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| Human | PTF1A-2638H | Recombinant Human PTF1A Protein, His-tagged | E.coli | N-His | Ala48-Pro115 |
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| Rat | PTF1A-4801R | Recombinant Rat PTF1A Protein | Mammalian Cell | His |
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| Rat | PTF1A-4460R | Recombinant Rat PTF1A Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | PTF1A-4460R-B | Recombinant Rat PTF1A Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | PTF1A-11836Z | Recombinant Zebrafish PTF1A | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- PTF1A Related Research Area
PTF1A involved in several pathways and played different roles in them. We selected most pathways PTF1A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
PTF1A has several biochemical functions, for example, DNA binding, protein dimerization activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTF1A itself. We selected most functions PTF1A had, and list some proteins which have the same functions with PTF1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | DEM1;MYCN;RPS3;IRX5A;H2AFB1;SSRP1;HISTH1L;TOX2;YBX1 |
| protein dimerization activity | NCOA2;FERD3L;FBXW11A;MGAA;ARNTL2;HES3;EBF4;BTRC;MYCB |
| sequence-specific DNA binding | MTA3;HESX1;SIX2B;NR6A1;IRX6;CREBZF;FOXP3A;OTP;HOXC12 |
| transcription factor activity, sequence-specific DNA binding | TARDBP;TBX2B;FLI1B;NTNG1;DMRTC1C2;OTX1B;EFCAB11;LHX8A;ZNF234 |
PTF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PTF1A.
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