Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

PTPLA

Official Full Name

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Overview

The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation.
Synonyms

PTPLA; protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A; protein tyrosine phosphatase like (proline instead of catalytic arginine), member a; 3-hydroxyacyl-CoA dehydratase 1; CAP; cementum attachment protein; HACD1; HACD1_HUMAN; Protein-tyrosine phosphatase-like member A; RP23-334M9.1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTPLA-2689HCL	Recombinant Human PTPLA 293 Cell Lysate	HEK293	N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PTPLA involved in several pathways and played different roles in them. We selected most pathways PTPLA participated on our site, such as Fatty acid elongation, Biosynthesis of unsaturated fatty acids, Fatty acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPLA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Fatty acid elongation	ELOVL7A;ELOVL5;ELOVL4B;ACOT1;HSD17B12A;ELOVL7;PTPLAD1;HADHA;PTPLAD2
Biosynthesis of unsaturated fatty acids	PTPLAD1;FADS2;PECR;ACOX1;ACOT1;FADS1;TECRB;SCD;ACOT5
Fatty acid metabolism	ACAT2;EHHADH;ACSL4B;ACAA2;SCD5;ACSL1A;ACAA1;ELOVL5;FADS1

PTPLA has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydratase activity, enzyme binding, hydroxyapatite binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPLA itself. We selected most functions PTPLA had, and list some proteins which have the same functions with PTPLA. You can find most of the proteins on our site.

Function	Related Protein
3-hydroxyacyl-CoA dehydratase activity	PTPLAD2;PTPLAD1;PTPLA
enzyme binding	GRIN1;PDE4D;PARP4;TMBIM6;THRB;HIST1H2AG;CBX4;MLL5;UBE2L3
hydroxyapatite binding	STATH;HTN1;BGLAP;BGLAP2;PTPLA;AMELX
lyase activity	GUCY2E;THA1;TSEN34;AMD2;GUCY2F;ECHDC2;THNSL2;Car2;GC3

PTPLA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPLA here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPLA.