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PTPN5

  • Official Full Name

    protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

  • Overview

    Striatal enriched phosphatase (STEP, also known as PTPN5), is a protein tyrosine phosphatase expressed in dopaminoceptive neurons of the central nervous system. Alternative splicing produces the cytosolic STEP46 and the membrane-associated STEP61 isoforms
  • Synonyms

    PTPN5; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); PTPSTEP; STEP;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPN5-2057H Recombinant Human PTPN5, GST-tagged E.coli GST 217-565aa
Human PTPN5-8092H Recombinant Human PTPN5 protein, His & T7-tagged E.coli His/T7 Ile331~Gln558 (Accession # P54829)
Human PTPN5-2682HCL Recombinant Human PTPN5 293 Cell Lysate HEK293 N/A
Human PTPN5-5689H Recombinant Human PTPN5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPN5-3058H Recombinant Human PTPN5 protein, His-tagged E.coli His 217-565 aa
Human PTPN5-6777HF Recombinant Full Length Human PTPN5 Protein, GST-tagged In Vitro Cell Free System GST 565 amino acids
Human PTPN5-1801H-B Recombinant Human PTPN5 Protein Pre-coupled Magnetic Beads HEK293
Human PTPN5-1801H Recombinant Human PTPN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PTPN5-3389H Recombinant Human PTPN5 protein, His-SUMO-tagged E.coli His-SUMO 300-555aa
Human PTPN5-833H Recombinant Human PTPN5 Protein, GST-tagged Wheat Germ GST
Human PTPN5-1106HFL Recombinant Full Length Human PTPN5 Protein, C-Flag-tagged Mammalian cells Flag
Human PTPN5-723H Recombinant Human PTPN5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PTPN5-4562H Recombinant Human PTPN5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPN5-3638H Recombinant Human PTPN5 protein, GST-tagged E.coli GST 217-565 aa
Mouse PTPN5-13687M Recombinant Mouse PTPN5 Protein Mammalian Cell His
Mouse Ptpn5-8093M Recombinant Mouse Ptpn5 protein, His & T7-tagged E.coli His/T7 Ala270~Lys533 (Accession # P54830)
Mouse PTPN5-7282M Recombinant Mouse PTPN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ptpn5-5241M Recombinant Mouse Ptpn5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PTPN5-7282M-B Recombinant Mouse PTPN5 Protein Pre-coupled Magnetic Beads HEK293
Rat PTPN5-4834R Recombinant Rat PTPN5 Protein Mammalian Cell His
Rat PTPN5-4493R-B Recombinant Rat PTPN5 Protein Pre-coupled Magnetic Beads HEK293
Rat PTPN5-4493R Recombinant Rat PTPN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mus musculus (Mouse) RFL31294MF Recombinant Full Length Mouse Tyrosine-Protein Phosphatase Non-Receptor Type 5(Ptpn5) Protein, His-Tagged E.coli expression system His Full Length (1-541)
Rhesus Macaque PTPN5-3708R Recombinant Rhesus monkey PTPN5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTPN5-3525R-B Recombinant Rhesus Macaque PTPN5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PTPN5-3525R Recombinant Rhesus Macaque PTPN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPN5 Related Articles

PTPN5 involved in several pathways and played different roles in them. We selected most pathways PTPN5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PTPN5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN5 itself. We selected most functions PTPN5 had, and list some proteins which have the same functions with PTPN5. You can find most of the proteins on our site.

Function Related Protein

PTPN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN5.

CXCL9; TMEM51; TMEM51; VTI1B; TERF1; ZBTB5; SNX4; FAM58A; CUL5; APOA1

Reinhart, VL; Nguyen, T; et al. DOWNSTREAM EFFECTS OF STRIATAL-ENRICHED PROTEIN TYROSINE PHOSPHATASE REDUCTION ON RNA EXPRESSION IN VIVO AND IN VITRO. NEUROSCIENCE 278:62-69(2014).
Francis, DM; Page, R; et al. Sequence-specific backbone H-1, C-13 and N-15 assignments of the 34 kDa catalytic domain of PTPN5 (STEP). BIOMOLECULAR NMR ASSIGNMENTS 8:185-188(2014).
  • Q&As
  • Reviews

Q&As (6)

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How is PTPN5 protein related to tumorigenesis? 09/11/2021

PTPN5 protein is aberrantly expressed in some types of tumors and may be involved in tumor formation and development by regulating signaling pathways.

What is the role of PTPN5 protein in brain development and maturation? 09/07/2021

This protein is involved in key events such as neuronal differentiation, migration, and synapse formation during brain development and maturation.

How is the enzymatic activity of PTPN5 protein regulated? 04/13/2021

The enzymatic activity of PTPN5 protein may be regulated by mechanisms such as phosphorylation modification and protein-protein interactions.

How about the therapeutic potential of PTPN5 protein in neurodegenerative diseases? 12/12/2020

The protein is being studied as a potential therapeutic target for neurodegenerative diseases, but there is no specific clinical application.

Is PTPN5 protein associated with depression or psychiatric disorders? 10/16/2020

PTPN5 protein may be associated with neuropsychiatric diseases such as depression and psychiatric disorders, but the specific mechanism needs to be further studied.

Is there a link between PTPN5 protein and cognitive function? 08/01/2020

Studies have shown that PTPN5 protein may be associated with cognitive functions (such as learning Xi memory), but the specific mechanism and role need to be further studied.

Customer Reviews (3)

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Reviews
06/03/2023

    The structural integrity of PTPN5 was verified, and the folding state and secondary structure were consistent with native proteins.

    06/24/2022

      PTPN5 has good DNA-binding ability and has performed well in related experiments.

      02/22/2022

        PTPN5 has good stability in solution and is not easy to aggregate or inactivate.

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