PTPN5
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Official Full Name
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
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Overview
Striatal enriched phosphatase (STEP, also known as PTPN5), is a protein tyrosine phosphatase expressed in dopaminoceptive neurons of the central nervous system. Alternative splicing produces the cytosolic STEP46 and the membrane-associated STEP61 isoforms -
Synonyms
PTPN5; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); PTPSTEP; STEP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PTPN5 Related Articles
PTPN5 involved in several pathways and played different roles in them. We selected most pathways PTPN5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PTPN5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN5 itself. We selected most functions PTPN5 had, and list some proteins which have the same functions with PTPN5. You can find most of the proteins on our site.
Function | Related Protein |
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PTPN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN5.
CXCL9; TMEM51; TMEM51; VTI1B; TERF1; ZBTB5; SNX4; FAM58A; CUL5; APOA1
- Q&As
- Reviews
Q&As (6)
Ask a questionPTPN5 protein is aberrantly expressed in some types of tumors and may be involved in tumor formation and development by regulating signaling pathways.
This protein is involved in key events such as neuronal differentiation, migration, and synapse formation during brain development and maturation.
The enzymatic activity of PTPN5 protein may be regulated by mechanisms such as phosphorylation modification and protein-protein interactions.
The protein is being studied as a potential therapeutic target for neurodegenerative diseases, but there is no specific clinical application.
PTPN5 protein may be associated with neuropsychiatric diseases such as depression and psychiatric disorders, but the specific mechanism needs to be further studied.
Studies have shown that PTPN5 protein may be associated with cognitive functions (such as learning Xi memory), but the specific mechanism and role need to be further studied.
Customer Reviews (3)
Write a reviewThe structural integrity of PTPN5 was verified, and the folding state and secondary structure were consistent with native proteins.
PTPN5 has good DNA-binding ability and has performed well in related experiments.
PTPN5 has good stability in solution and is not easy to aggregate or inactivate.
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