Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

PTPRO

  • Official Full Name

    protein tyrosine phosphatase, receptor type, O

  • Overview

    This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer.
  • Synonyms

    PTPRO; protein tyrosine phosphatase, receptor type, O; receptor-type tyrosine-protein phosphatase O; GLEPP1; NPHS6; osteoclastic transmembrane protein tyrosine phosphatase; PTP oc; PTP U2; PTPU2; GLEPP 1; Glomerular epithelial protein 1; Phosphotyrosine phosphatase U2; Protein tyrosine phosphatase PTP U2; Protein tyrosine phosphatase PTPU2; Protein tyrosine phosphatase receptor type O; Protein tyrosine phosphatase U2; PTP-U2; PTPase U2; PTPRO_HUMAN; PTPROt; PTPU 2; R-PTP-O; Receptor type protein tyrosine phosphatase O; Receptor type tyrosine protein phosphatase O; PTP phi; protein tyrosine phosphatase PTP-U2; osteoclastic transmembrane protein-tyrosine phosphatase; PTP-OC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTPRO-28853TH Recombinant Human PTPRO Wheat Germ N/A 598 amino acids
Human PTPRO-28582TH Recombinant Human PTPRO Wheat Germ N/A 180 amino acids
Human PTPRO-2672HCL Recombinant Human PTPRO 293 Cell Lysate HEK293 N/A
Human PTPRO-2673HCL Recombinant Human PTPRO 293 Cell Lysate HEK293 N/A
Human PTPRO-2674HCL Recombinant Human PTPRO 293 Cell Lysate HEK293 N/A
Human PTPRO-6716H Recombinant Human PTPRO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPRO-2643H Recombinant Human PTPRO Protein, His-tagged E.coli N-His Phe938-Met1195
Human PTPRO-6718H Recombinant Human PTPRO Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PTPRO-418HF Recombinant Full Length Human PTPRO Protein In Vitro Cell Free System 598 amino acids
Mouse PTPRO-13704M Recombinant Mouse PTPRO Protein Mammalian Cell His
Mouse Ptpro-6812M Recombinant Mouse Ptpro protein, His & T7-tagged E.coli His/T7 Phe948~Met1205 (Accession # E9Q612)
Mouse PTPRO-7289M Recombinant Mouse PTPRO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ptpro-5250M Recombinant Mouse Ptpro Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PTPRO-7289M-B Recombinant Mouse PTPRO Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PTPRO-5438Z Recombinant Zebrafish PTPRO Mammalian Cell His
Chicken PTPRO-5698C Recombinant Chicken PTPRO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTPRO Related Articles

PTPRO involved in several pathways and played different roles in them. We selected most pathways PTPRO participated on our site, such as Signaling events mediated by Stem cell factor receptor (c-Kit), which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling events mediated by Stem cell factor receptor (c-Kit)MAP4K1;SH2B3;PTPRO;STAP1;EVLA

PTPRO has several biochemical functions, for example, Wnt-protein binding, phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRO itself. We selected most functions PTPRO had, and list some proteins which have the same functions with PTPRO. You can find most of the proteins on our site.

Function Related Protein
Wnt-protein bindingLRP5L;SFRP1B;FZD5;Fzd4;SMO;WLS;GPR177;FRZB;FZD8A
phosphatase activityPTPN11B;PTPN20;CDC14A;PTPN11A;DUSP3B;CA3;CAR3;CTDSPL2B;CTDNEP1
protein bindingPSEN1;FAM53C;IL28RA;NAB2;ARRB1;FOXO4;CTNNA3;PFDN2;PTEN
protein homodimerization activityBMP2B;BHLHA15;GNB2L1;AADAT;CARM1;TFAP2A;KCNH2;CTBP1;DGCR8
protein tyrosine phosphatase activityDUSP10;PTPRA;PTPN2B;DUSP18;CDC25C;DUSP13A;PTPN2;MTMR7A;DNAJC6
transmembrane receptor protein tyrosine phosphatase activityPTPRO;PTPRS;PTPRF;PTPRUB;PTPRD;PTPRB;PTPRR;PTPRG;PTPRE

PTPRO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRO here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRO.

PDPK1; ERBB2; NTRK1; INSR; LCK; MET; PDGFRB; CDH2; EPOR; CBL; MAPK3; CTNNB1; CSK; TEC; WAS; NSF; PXN; TEK

Liu, Z; Hou, JJ; et al. Protein tyrosine phosphatase receptor type O expression in the tumor niche correlates with reduced tumor growth, angiogenesis, circulating tumor cells and metastasis of breast cancer. ONCOLOGY REPORTS 33:1908-1914(2015).
Jiang, RQ; Chen, DY; et al. Survival and Inflammation Promotion Effect of PTPRO in Fulminant Hepatitis Is Associated with NF-kappa B Activation. JOURNAL OF IMMUNOLOGY 193:5161-5170(2014).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All PTPRO Products

Required fields are marked with *

My Review for All PTPRO Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends