PUF60
-
Official Full Name
poly-U binding splicing factor 60KDa
-
Overview
The protein encoded by this gene is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene. -
Synonyms
PUF60; poly-U binding splicing factor 60KDa; poly(U)-binding-splicing factor PUF60; FBP interacting repressor; FIR; pyrimidine tract binding splicing factor; Ro ribonucleoprotein binding protein 1; RoBPI; siah binding protein 1; SIAHBP1; FLJ31379; fuse-binding protein-interacting repressor; poly-U binding splicing factor PUF60; Ro ribonucleoprotein-binding protein 1; roBP1; siah-BP1; ro-binding protein 1; siah-binding protein 1; FBP-interacting repressor; 60 kDa poly(U)-binding-splicing factor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PUF60 Related Articles
PUF60 involved in several pathways and played different roles in them. We selected most pathways PUF60 participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PUF60 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | SRSF4;HNRNPUB;SRSF5B;SFRS3B;HNRPK;THOC1;CRNKL1;LSM2;DHX8 |
PUF60 has several biochemical functions, for example, DNA binding, identical protein binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PUF60 itself. We selected most functions PUF60 had, and list some proteins which have the same functions with PUF60. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | POLR2J2;TXLNB;ZZZ3;SOX3;ZNF599;HOXC13;HIST4H4;ILF3B;VED |
| identical protein binding | ADIPOR1;FTL;CREBZF;MYD88;MID1;SHARPIN;ESYT2;LTBR;BCL2L1 |
| nucleotide binding | RAB25B;GMPPAB;RBFOX2;TUBA2;NTRK3A;RBPMS;UBE2NB;U2SURP;MYO7A |
| poly(A) RNA binding | TRMT1;PCBP1;AGO3;FCF1;ETF1B;RTCD1;U2SURP;HIST1H4D;SRSF11 |
| protein binding | FGFR2;ADAMTS5;HDAC7A;HINFP;IPO11;EMILIN1;GBP2;FAM81B;C19orf40 |
PUF60 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PUF60 here. Most of them are supplied by our site. Hope this information will be useful for your research of PUF60.
SAP30BP; U2AF2; SIAH1
- Q&As
- Reviews
Ask a Question for All PUF60 Products
Required fields are marked with *
My Review for All PUF60 Products
Required fields are marked with *
