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PURB

Official Full Name

purine-rich element binding protein B
Overview

This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
Synonyms

PURB; purine-rich element binding protein B; transcriptional activator protein Pur-beta; PURBETA; purine-rich element-binding protein B;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Bacillus subtilis
Human
Mouse
Rat

Source

E. coli or Yeast
E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PURB-2072H	Recombinant Human PURB, GST-tagged	E.coli	GST	1-312aa	$319 / 25ug
Human	PURB-193H	Recombinant Human PURB, His-tagged	E.coli	His	1-312aa	Inquiry
Mouse	PURB-13723M	Recombinant Mouse PURB Protein	Mammalian Cell	His		Inquiry
Mouse	PURB-7302M	Recombinant Mouse PURB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PURB-7302M-B	Recombinant Mouse PURB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PURB-4850R	Recombinant Rat PURB Protein	Mammalian Cell	His		Inquiry
Rat	PURB-4509R	Recombinant Rat PURB Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	PURB-4509R-B	Recombinant Rat PURB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bacillus subtilis	PURB-0186B	Recombinant Bacillus subtilis PURB protein, His-tagged	E. coli or Yeast	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PURB involved in several pathways and played different roles in them. We selected most pathways PURB participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PURB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PURB has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, SMAD binding, mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PURB itself. We selected most functions PURB had, and list some proteins which have the same functions with PURB. You can find most of the proteins on our site.

Function	Related Protein
RNA polymerase II regulatory region sequence-specific DNA binding	ATF3;MNT;EAF2;CREB3L4;ZNF79;HOXD8;GATA5;PHOX2B;TBX5
SMAD binding	BMPR1B;COL1A2;COL3A1;HIPK2;ACVR1B;STUB1;DAB2;COL5A2;SKOR1
mRNA binding	LUC7L;XPO5;TDRD7;MRPL13;RBM25;RPS2;CPSF5;THOC2;DPPA5A
poly(A) RNA binding	HIST1H1C;ACTN4;RPL29;CROP;RPL22;HIST1H4L;MRPL3;MRPL39;USP10
single-stranded DNA binding	NABP1;CDAN1;TTC6;ANXA1;MLH3;RAD51D;PEO1;LONP1;RPA3
transcription factor binding	KLF5;E2F4;NKX3;TBX5;RARA;KCNA3;DRAP1;NCOA2;IFI16
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	ISX;ZC3H8;JARID2;ETV7;CDX2;VAX2;PURB;ZEB1;BCL6A

PURB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PURB here. Most of them are supplied by our site. Hope this information will be useful for your research of PURB.

CSNK2A1; q8te30_human; ESR2; UVRAG