pycard
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  • Official Full Name
  • PYD and CARD domain containing
  • Background
  • Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.
  • Synonyms
  • PYCARD; PYD and CARD domain containing; apoptosis-associated speck-like protein containing a CARD; ASC; CARD5; TMS 1; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; TMS; TMS1; TMS-1; MGC10332
Cat.#:PYCARD-29108HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PYCARD, GST-tagged
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Cat.#:PYCARD-3718RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PYCARD Protein, His-tagged
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Cat.#:PYCARD-9047ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PYCARD
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Cat.#:PYCARD-2648HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PYCARD 293 Cell Lysate
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Cat.#:PYCARD-2649HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PYCARD 293 Cell Lysate
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Cat.#:PYCARD-2650HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PYCARD 293 Cell Lysate
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Involved Pathway

PYCARD involved in several pathways and played different roles in them. We selected most pathways PYCARD participated on our site, such as NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYCARD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NOD-like receptor signaling pathway
IKBKB; NLRC4; MAPK12; TNF; HSP90AA1; NLRP3; MAP3K7; NLRP1; MAPK8A; MAPK12A
Cytosolic DNA-sensing pathway
IFNA13; NFKBIA; MB21D1; IFNA4; POLR1C; IFN-a; PYCARD; IFNA12; RIPK1; NFKBIAA
Salmonella infection
RILP; RHOGC; DYNC1LI2; CASPA; CD14; ARPC5A; CXCL2; MYH9; MAPK11; PKN3
Pertussis
LY96; IL23; IRF1; MYD88; MAPK1; C4BPA; C4A; CD14; SERPING1; NLRP3
Legionellosis
RAB1A; CASP9; IL12B; RAB1; NFKB2; TLR4; NFKB1; ITGB2L; CR1; TNF
Influenza A
PIK3R1; TLR3; IFNA7; HSPA1L; HLA-DQB1; IRF3; PIK3CD; IFNA1; MAPK13; TNFRSF10B

Protein Function

PYCARD has several biochemical functions, for example, BMP receptor binding, Pyrin domain binding, cysteine-type endopeptidase activator activity involved in apoptotic process. Some of the functions are cooperated with other proteins, some of the functions could acted by PYCARD itself. We selected most functions PYCARD had, and list some proteins which have the same functions with PYCARD. You can find most of the proteins on our site.
Function
Related Protein
Function BMP receptor binding
Related Protein BMP7B; PYCARD; BMP8B; BMP4; BMP8A; BMP5; BMP7A; BMP7; BMP2B; BMP3
Function Pyrin domain binding
Related Protein PYCARD; NLRP2; CASPA
Function cysteine-type endopeptidase activator activity involved in apoptotic process
Related Protein APAF1; GNB2L1; NOD1; CTSH; BAD; PYCARD; NLRP1; NLRP12; RPS27L; CASP1
Function enzyme binding
Related Protein CSF3; SPDL1; GBP1; KRT79; SLC12A3; YWHAB; YWHAE; TSPAN14; CRB2; APP
Function identical protein binding
Related Protein RABAC1; SYP; NISCH; DVL2; CLDN7; ORAI1; ESYT2; CLDN1; CSK; NDE1
Function interleukin-6 receptor binding
Related Protein CNTF; ERAP1; IL6; PYCARD; ADAM17
Function myosin I binding
Related Protein PYCARD
Function protease binding
Related Protein ALPI; DVL3; PYCARD; SERPINC1; LRP1; RFFL; PANX1; SERPINA1D; STIM1; TNF
Function protein binding
Related Protein SRSF7; FAM168A; ASB13; UPRT; GLE1; PTGDS; PEPD; DNTTIP1; CDK7; CCBL1
Function protein homodimerization activity
Related Protein TRPM8; TMEM192; HNF1A; BOKB; TFAP2E; CHMP4C; GNPTG; SDCBP; KLHL7; RAG1
Function tropomyosin binding
Related Protein LMOD1; TMOD2; TMOD1; LMOD3; TMOD3; TNNT1; S100A6; NEBL; LMOD2A; TMOD4

Interacting Protein

PYCARD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYCARD here. Most of them are supplied by our site. Hope this information will be useful for your research of PYCARD.
AIM2; NLRP3

PYCARD Related Articles

Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).