PYGL
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Official Full Name
phosphorylase, glycogen, liver
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Overview
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
PYGL; phosphorylase, glycogen, liver; phosphorylase, glycogen; liver; glycogen phosphorylase, liver form; glycogen storage disease type VI; Hers disease; GSD6;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | PYGL-43H | Recombinant Human PYGL, His-tagged | E.coli | His | ||
Human | PYGL-31270TH | Recombinant Human PYGL | Wheat Germ | N/A | 847 amino acids | |
Human | PYGL-7823H | Recombinant Human PYGL protein, His-tagged | E.coli | His | Asn633~Glu820 (Accession # P06737) | |
Human | PYGL-1819H | Recombinant Human PYGL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | PYGL-759H | Recombinant Human PYGL Protein (2-846 aa), GST-tagged | E.coli | GST | 2-846 aa | |
Human | PYGL-3176H | Recombinant Human PYGL Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | PYGL-1819H-B | Recombinant Human PYGL Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | PYGL-6128H | Recombinant Human PYGL Protein (Gln370-Val538), N-His tagged | E.coli | N-His | Gln370-Val538 | |
Human | PYGL-1497H | Recombinant Human PYGL Protein (2-846 aa), His-tagged | Yeast | His | 2-846 aa | |
Human | PYGL-416HF | Recombinant Full Length Human PYGL Protein | In Vitro Cell Free System | 847 amino acids | ||
Human | PYGL-1275HFL | Recombinant Full Length Human PYGL Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Mouse | Pygl-453M | Recombinant Mouse Pygl Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | Pygl-2009M | Recombinant Mouse Pygl Protein, His-tagged | E.coli | N-His | Thr603-Phe750 | |
Rat | PYGL-4859R | Recombinant Rat PYGL Protein | Mammalian Cell | His | ||
Rat | Pygl-7824R | Recombinant Rat Pygl protein, His-tagged | E.coli | His | Thr341~Gly509 (Accession# P09811) | |
Rat | Pygl-7825R | Recombinant Rat Pygl protein, His-tagged | E.coli | His | Thr603~Phe750 (Accession # P09811) | |
Rat | Pygl-7826R | Recombinant Rat Pygl protein, His-tagged | E.coli | His | Gln73~Val267 (Accession # P09811) | |
Rat | PYGL-4518R-B | Recombinant Rat PYGL Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | PYGL-4518R | Recombinant Rat PYGL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | PYGL-1871Z | Recombinant Zebrafish PYGL | Mammalian Cell | His | ||
Chicken | PYGL-5962C | Recombinant Chicken PYGL | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- PYGL Related Articles
PYGL involved in several pathways and played different roles in them. We selected most pathways PYGL participated on our site, such as Starch and sucrose metabolism, Metabolic pathways, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PYGL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Starch and sucrose metabolism | HK1;PGM2L1;GUSB;AMY2A;UGT1A6A;GPIA;AGLA;AMY1A;AMY2B |
Metabolic pathways | ACOT2;AGPS;HSD3B2;ENPP7;PCCA;PNAT10;CRYL1;ST8SIA5;ADK |
Insulin signaling pathway | INS1;EIF4E2RS1;INSB;PRKACAA;PKLR;SOCS3B;FOXO1;G6PCA.2;PYGMA |
Insulin resistance | RPS6KB1B;PPP1R3CA;PRKAG3;PPP1CAB;OGT.1;CREB3L3;PPP1R3DA;PIK3CA;PTPRFB |
PYGL has several biochemical functions, for example, AMP binding, ATP binding, bile acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PYGL itself. We selected most functions PYGL had, and list some proteins which have the same functions with PYGL. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
AMP binding | PRKAG1;PRPS2;PYGM;ACSS2;FBP1;PRKAG2;CYB5R3;PRPS1;ACSS1 |
ATP binding | MAPK11;BCR;CSF1RA;ATRX;VRK3;PCCB;UCKL1A;HELZ;ITPKB |
bile acid binding | FABP1;STARD5;AKR1C2;PLA2G1B;FABP10A;AKR1C21;FABP6;PYGL;NR1H4 |
drug binding | DHODH;PPARD;ATP5O;HTR2C;CHRM1;FNTB;HTR2A;CYP2C9;ACE |
glucose binding | HKDC1;G6PDX;SLC2A8;PYGL;HK2;HK3;UGP2;SLC2A3;GYS1 |
glycogen phosphorylase activity | PYGMB;PYGB;PYGL;PYGMA;PYGM |
protein binding | NBL1;SEC61G;COG8;LARS;SFRP1;MLANA;ATP2B4;PSMB4;NOTCH4 |
protein homodimerization activity | TWIST1;MGLL;IZUMO3;PARK7;AGXT;CHUK;DMRT2B;NR0B2;S100A5 |
purine nucleobase binding | PNP;PYGL |
pyridoxal phosphate binding | MOCOS;GOT2A;AGXT;MARC2;CCBL1;SRR;HINT2;MARC1;SHMT1 |
vitamin binding |
PYGL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PYGL here. Most of them are supplied by our site. Hope this information will be useful for your research of PYGL.
PYGB; USP19; IDH2; BAG1; HSD3B7; IKBKB; GABARAPL2; FKBP5; Ripk3
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