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PADI2

  • Official Full Name

    peptidyl arginine deiminase, type II

  • Overview

    This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.
  • Synonyms

    PADI2; peptidyl arginine deiminase, type II; protein-arginine deiminase type-2; KIAA0994; PDI2; OTTHUMP00000044625; PAD 2; PAD H19; PADI 2; PADI2 protein; PDI 2; Peptidlyarginine deiminase type II; Peptidyl arginine deiminase II; Peptidyl arginine deiminase type II; Peptidylarginine deiminase II; Protein arginine deiminase; Protein arginine deiminase type 2; Protein arginine deiminase type II; OTTHUMP00000002403; OTTHUMP00000002404; protein-arginine deiminase type II; PAD2; PAD-H19;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • HEK293T
  • Insect cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • Strep
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|SUMO
  • DDK
  • Myc|DDK
  • N
  • TwinStrep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PADI2-187H Active Recombinant Human PADI2, Flag-tagged Sf9 Insect Cell Flag
Human PADI2-186H Recombinant Human PADI2, GST-tagged Wheat Germ GST
Human PADI2-5628H Recombinant Human PADI2, MYC/DDK-tagged HEK293 Myc/DDK
Human PADI2-1164H Recombinant Human PADI2 Protein (1-665 aa), His-SUMO-tagged E.coli His/SUMO 1-665 aa
Human PADI2-1735H Recombinant Human PADI2 Protein (1-665 aa), His-tagged Yeast His 1-665 aa
Human PADI2-311H Recombinant Human PADI2 Protein, His/GST-tagged E.coli His/GST Met1~ Thr300
Human PADI2-0609H Recombinant Human PADI2 protein, His-tagged Baculovirus-Insect cells His Met1-Pro665
Human PADI2-008H Recombinant Human PADI2 Protein, His-tagged Insect Cells His
Human PADI2-102H Active Recombinant Human PADI2 Protein, His-tagged Insect cell His
Human PADI2-0150H Recombinant Human PADI2 Protein (Met1-Pro665), N-TwinStrep-tagged Baculovirus-Insect cells N-TwinStrep Met1-Pro665
Human PADI2-1634H Recombinant Human PADI2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PADI2-3970H Recombinant Human PADI2 Protein (Met1-Pro665), N-Strep tagged Mammalian cells N-Strep Met1-Pro665
Human PADI2-3812HFL Recombinant Full Length Human PADI2, Flag-tagged Mamanlian cells Flag
Human PADI2-5927H Recombinant Human PADI2 protein, His&Myc-tagged HEK293 His&Myc 1-665aa
Mouse PADI2-6979M Recombinant Mouse PAD2, GST-tagged Sf9 Insect Cell GST Full length
Mouse Padi2-0147M Recombinant Mouse Padi2 Protein (Met1-Pro673), C-Strep-tagged Baculovirus-Insect cells C-Strep Met1-Pro673
Mouse Padi2-4652M Recombinant Mouse Padi2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Padi2-0146M Recombinant Mouse Padi2 Protein (Met1-Pro673), N-TwinStrep-tagged Baculovirus-Insect cells N-TwinStrep Met1-Pro673
Mouse PADI2-0608M Recombinant Mouse PADI2 protein, His-tagged Baculovirus-Insect cells His Met1-Pro673
Rat PADI2-4249R Recombinant Rat PADI2 Protein Mammalian Cell His
Rat PADI2-3911R Recombinant Rat PADI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PADI2-3911R-B Recombinant Rat PADI2 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus PADI2-0607C Recombinant Cynomolgus PADI2 protein, His-tagged Baculovirus-Insect cells His Met1-Pro665
Rhesus Macaque PADI2-3281R Recombinant Rhesus monkey PADI2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PADI2-3099R Recombinant Rhesus Macaque PADI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PADI2-3099R-B Recombinant Rhesus Macaque PADI2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PADI2-10464Z Recombinant Zebrafish PADI2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PADI2 Related Articles
  • PADI2 Related Research Area

PADI2 involved in several pathways and played different roles in them. We selected most pathways PADI2 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, protein citrullination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PADI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chromatin modifying enzymesAEBP2;SMYD3;TAF6L;ANO9A;ARID2;MSL3;CCDC101;PRMT5;NCOA2
Chromatin organizationATXN7L3;KDM6B;CHD4;KDM1B;CCDC101;EPC1;PBRM1;ARID1A;BRMS1
protein citrullinationPADI4;PADI2;PADI1;PADI6;PADI3

PADI2 has several biochemical functions, for example, calcium ion binding, estrogen receptor binding, protein-arginine deiminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PADI2 itself. We selected most functions PADI2 had, and list some proteins which have the same functions with PADI2. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDHGA8;CALRL2;EFHD2;NCL;DSG2;FSTL1A;CETN3;SYT17;TBC1D9B
estrogen receptor bindingDYX1C1;TRIP4;FUS;STRN;CNOT1;CTNNB1;FOXL2;CCDC62;DDX54
protein-arginine deiminase activityPADI2;PADI1;PADI3;PADI6;PADI4

PADI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PADI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PADI2.

MYC

Hsu, PC; Liao, YF; et al. Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells. MOLECULES AND CELLS 37:426-434(2014).
Chang, XT; Xia, YF; et al. PADI2 Is Significantly Associated with Rheumatoid Arthritis. PLOS ONE 8:-(2013).
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