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PAG1

Official Full Name

phosphoprotein associated with glycosphingolipid microdomains 1
Overview

Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A, bind to this element. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.
Synonyms

PAG1; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; CBP; Csk binding protein; PAG; transmembrane adaptor protein PAG; Csk-binding protein; transmembrane phosphoprotein Cbp; transmembrane adapter protein PAG; FLJ37858; MGC138364;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PAG1-30060TH	Recombinant Human PAG1, His-tagged	E.coli	His		Inquiry
Human	PAG1-3465HCL	Recombinant Human PAG1 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	Pag1-521M	Recombinant Mouse Pag1 Protein, His-tagged	E.coli	His	Gly160~Gln390	$298 / 10ug
Rat	Pag1-522R	Recombinant Rat Pag1 Protein, His-tagged	E.coli	His	Ile138~Phe357	$298 / 10ug
Bovine	PAG1-0031B	Recombinant Bovine PAG1 Protein (Arg54-Val380), N-His-tagged	E.coli	N-His	Arg54-Val380	Inquiry

Involved Pathway
Protein Function
Interacting Protein
PAG1 Related Research Area

PAG1 involved in several pathways and played different roles in them. We selected most pathways PAG1 participated on our site, such as Adaptive Immune System, BCR signaling pathway, CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	SIGLEC6;SPSB1;RBCK1;RACGAP1;WSB1;TRAF7;KIF5B;NA;MICA
BCR signaling pathway	PAG1;DOK1;IBTK;CSNK2A1;CSK;MAP4K1;NETO2;MALT1;POU2F2
CXCR4-mediated signaling events	CFL1;DNM1;PAG1;JAK2;ADRBK1;GNB2L1;GNA13;ARR3;CSK
GAB1 signalosome
Immune System	SPSB1;WASF3;DCTN6;KLRG1;BTR22;HLA-DQB2;TLR6;PANX1B;EDARADD
Phosphorylation of CD3 and TCR zeta chains
Signal Transduction	PTPRUB;ASH2L;NOG1;KTN1;FFAR3;ARHGAP9;SCUBE2;WDR35;CBY1
Signaling by EGFR	SPRY1;ADAM12;PAG1;LRIG1;PTPRK

PAG1 has several biochemical functions, for example, SH2 domain binding, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAG1 itself. We selected most functions PAG1 had, and list some proteins which have the same functions with PAG1. You can find most of the proteins on our site.

Function	Related Protein
SH2 domain binding	CRK;CTR9;AFAP1L2;SQSTM1;SYNGR3;IRS1;DLC1;ARHGAP5;SRC
SH3/SH2 adaptor activity	SH2D3C;SH2D3A;NCK1;GRB2;SRC;SH2D2A;LAT;EPS8;GRAP
protein binding	DYDC1;GPR158;PKN1;SPINK7;TRPC6;HCK;PDCL3;FREM2;SH3GL1

PAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAG1.

FYN; SLC9A3R1; LYN; EGFR; PRKCB; GNB2L1; ppaC; CSK

Mast Cells