PARP1
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Official Full Name
poly (ADP-ribose) polymerase 1
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Overview
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008] -
Synonyms
PARP1; poly (ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect cell
- Insect Cell
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Sf21 Insect Cell
- Sf21 insect cells
- Sf9 Insect Cell
- C
- His
- Myc
- DDK
- Flag
- FLAG
- Avi
- GST
- HA
- His (Fc)
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PARP1 Related Articles
- PARP1 Related Research Area
PARP1 involved in several pathways and played different roles in them. We selected most pathways PARP1 participated on our site, such as Base Excision Repair, Caspase cascade in apoptosis, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Base Excision Repair | UNG;POLE3;PARP1;PARP2;LIG1;SMUG1;MBD4;LIG3;PARP4 |
Caspase cascade in apoptosis | ACTA1;CFL2;CASP2;GAS2;LMNB1;DFFA;CASP4;SATB1;NUMA1 |
Corticotropin-releasing hormone | CASP12;PARP1;TRIM28;KRT14;TBX19;CYP21A2;KRT1;CYP11A1;ADRBK2 |
DNA Damage Recognition in GG-NER | COPS7B;DDB1;COPS3;COPS4;ACTR5;COPS5;INO80B;INO80;INO80E |
DNA Double-Strand Break Repair | BRE;TIPIN;KIAA0146;CLSPN;RAD9;UIMC1;RTEL1;THRSP;BABAM1 |
DNA Repair | YY1A;TIPIN;GPS1;RIF1;DTL;PPP4CB;UIMC1;INO80;PARP2 |
Downregulation of SMAD2/3:SMAD4 transcriptional activity | TRIM33;SKI;USP9X;RNF111;SKILB;PARP1;SKIB;SMAD3B;SKIA |
PARP1 has several biochemical functions, for example, DNA binding, NAD binding, NAD+ ADP-ribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP1 itself. We selected most functions PARP1 had, and list some proteins which have the same functions with PARP1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF781;UNCX4.1;YBX2;RIMKLB;NEUROG1;ZBTB25;POT1A;TFDP1;ZFP260 |
NAD binding | TESCA;AHCY;IDH3A;HPGD;PARP1;ME1;DLD;HIBADH;SORD |
NAD+ ADP-ribosyltransferase activity | SIRT6;GIG2Q;GIG2K;TNKS;PARP3;PARP16;PARP15;PARP6;PARP4 |
R-SMAD binding | SMAD2;FOS;MYOCD;PAX6;ZEB2;TRIM33;CTNNB1;SMAD3;RANBP3 |
chromatin binding | UXT;NFATC3;TLE4;PRKAA1;NR5A1A;CCDC111;SMC1AL;POLE;HMGB4 |
enzyme binding | CLSTN2;CYP2A4;PRTN3;TSPAN17;JUND;FAM84B;TTN;HMOX1;HIST1H2AK |
identical protein binding | SDCBP;RB1;DESI1;VWA1;KCNH2;UAP1;SH3GL3;S100A1;VAMP2 |
poly(A) RNA binding | DYNC1LI1;ZMAT3;HIST1H4H;NPM3;DDX55;RBM26;DDX54;CCDC86;GTPBP1 |
protein N-terminus binding | HAX1;VPS25;PDCD10;HESX1;HDAC1;MAP2K1;CHMP6;EXOC5;EXOC4 |
protein binding | CTNNBIP1;OCRL;ATF7;SUN2;UBE2H;SCP2;SLC25A46;RASSF2;NPM1 |
protein kinase binding | MAPK6;TPCN2;PEBP1;PTEN;MAVS;TUBB3;CD36;RPS3;AGTR1A |
transcription factor binding | FOXA2;VDRA;IFI203;KAT2B;NAB2;TCF3;TRIB2;KEAP1;C1QBP |
zinc ion binding | EWSR1B;TRIM65;ADAMTS15A;NANOS3;TRIM43A;BMP1;WBP2NL;RERE;MEP1B |
PARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP1.
XRCC5; TP53; WRN
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, overactivation of the PARP1 protein can lead to apoptosis or necrosis of cells, which may be exploited in the treatment of certain diseases.
The PARP1 protein can repair DNA damage by attaching ADP-ribose groups to damaged DNA strands and recruiting other repair proteins.
In addition to PARP1's involvement in direct DNA repair, it can also modulate the selection of repair pathways and initiate other DNA damage sensing mechanisms.
Some studies have proposed that the interaction of PARP1 protein with DNA damage in tumor immunotherapy may affect the efficacy of immunotherapy.
Yes, the PARP1 protein is involved in the normal regulation of the cell cycle, especially G1/S and G2/M switching during DNA damage.
Overactivation of PARP1 depletes energy stores such as NAD+ and ATP and leads to apoptosis, or cell death.
Customer Reviews (3)
Write a reviewThis range of applications of PARP1 is breathtaking, and it can play an important role in any field.
This short half-life and high clearance of PARP1 make it have greater potential in the treatment of tumors, infections and other diseases, and it is expected to become a new generation of therapeutic drugs.
The purity and bioactivity of PARP1 make it a valuable resource for scientific research.
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