pde12
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  • Official Full Name
  • phosphodiesterase 12
  • Background
  • Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP
  • Synonyms
  • PDE12; phosphodiesterase 12; 2,5-phosphodiesterase 12; 2 PDE; 2 phosphodiesterase; DKFZp667B1218; 2-PDE; 2-phosphodiesterase
Cat.#:PDE12-744HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDE12 Protein, MYC/DDK-tagged
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Cat.#:Pde12-305MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pde12 Protein, His-tagged
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Cat.#:PDE12-1611HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE12, GST-tagged
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Cat.#:PDE12-1714HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PDE12
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Cat.#:PDE12-12546MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDE12 Protein
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Cat.#:PDE12-3344RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PDE12 Protein, His-tagged
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Cat.#:PDE12-4280ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDE12
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Protein Function

PDE12 has several biochemical functions, for example, metal ion binding, poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE12 itself. We selected most functions PDE12 had, and list some proteins which have the same functions with PDE12. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein CYGB2; ZNF750; CLCA1; ZKSCAN6; ARFGAP2; CRYABA; RNF207; FDX1B; SUCLA2; ZNF286A
Function poly(A)-specific ribonuclease activity
Related Protein CNOT6L; CNOT6; CNOT7; TOE1; CNOT8; PDE12; PAN2; PARN

Interacting Protein

PDE12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE12.
UBL4A; BAG6; SGTB; VWA9; SORT1; Rhoa; SIRT4

PDE12 Related Articles

Braun, J; Kiltz, U; et al. Emerging drugs for the treatment of axial and peripheral spondyloarthritis. EXPERT OPINION ON EMERGING DRUGS 20:1-14(2015).
Felquer, MLA; Soriano, ER; et al. New treatment paradigms in psoriatic arthritis: an update on new therapeutics approved by the US Food and Drug Administration. CURRENT OPINION IN RHEUMATOLOGY 27:99-106(2015).