PDIA3
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Official Full Name
protein disulfide isomerase family A, member 3
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Overview
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008] -
Synonyms
PDIA3; protein disulfide isomerase family A, member 3; P58; ER60; ERp57; ERp60; ERp61; GRP57; GRP58; PI-PLC; HsT17083; HEL-S-269; HEL-S-93n; protein disulfide-isomerase A3; ER protein 57; ER protein 60; phospholipase C-alpha; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; 58 kDa glucose-regulated protein; glucose regulated protein, 58kDa; epididymis secretory protein Li 269; protein disulfide isomerase-associated 3; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 93n;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PDIA3 Related Articles
PDIA3 involved in several pathways and played different roles in them. We selected most pathways PDIA3 participated on our site, such as Protein processing in endoplasmic reticulum, Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDIA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | HSP90AA1;UBE2G1;NFE2L2A;SEL1L2;UBE2D1A;UBE2D2;TRAF2;DNAJC5GB;SEC24B |
| Antigen processing and presentation | CD8A;NFYC;HSPA4;HLA-C;HLA-DPB1;CD74;H2-AA;HSPA5;HSPA1B |
PDIA3 has several biochemical functions, for example, cysteine-type endopeptidase activity, disulfide oxidoreductase activity, phospholipase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDIA3 itself. We selected most functions PDIA3 had, and list some proteins which have the same functions with PDIA3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | CTSL1;USP40;USP12A;USP2A;USP51;CASP6L2;USP37;MALT1A;CTSLL |
| disulfide oxidoreductase activity | GRX2;DNAJC10;TXNL1;COIL;PDIA2;TMX1;PDIA3;TXN |
| phospholipase C activity | PLCB2;PLCB3;PLCH2;PLCL1;PLCG1;PLCB4;ADORA1;PLCG2;PDIA3 |
| poly(A) RNA binding | HIST1H4E;TES;C7orf50;REXO4;WDR46;MAGOH2;ZFP598;TPD52L2;EZR |
| protein binding | XIRP2;RASSF2;SMURF1;FAM151B;CDC6;HEBP2;RBL2;XPO1;SCAND1 |
| protein disulfide isomerase activity | PDILT;PDIA5;ERO1L;PDIP5;P4HB;GLRX2;TXNDC11;PIGK;TMX1 |
PDIA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDIA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDIA3.
ERO1L; CLU; STIM1; APP; TAP1; env; Edem3; AGRN
- Q&As
- Reviews
Q&As (5)
Ask a questionOverexpression of PDIA3 inhibits H2O2-induced inflammatory responses in astrocytes.
PDIA3 has been closely associated with the study of cervical, colorectal and kidney cancers.
PDIA3 promotes protein folding and is involved in the process of malignant tumorigenesis and development such as breast cancer and gastric cancer.
PDIA3 expression in renal cancer tissues is higher than that in renal cancer paracancerous tissues, and it becomes a new candidate marker for the diagnosis of renal cancer.
PDIA3 is a chaperone protein that not only performs protein modification and folding but also acts as a base sparing and redox protein at the same time.
Customer Reviews (3)
Write a reviewThe PDIA3 protein product received was as advertised, top quality and good value for money.
Prompt delivery helped me get satisfactory experimental results in a short period of time.
The technician guided me through the process, which led to satisfactory results.
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